Motif ID: E2f7

Z-value: 1.805


Transcription factors associated with E2f7:

Gene SymbolEntrez IDGene Name
E2f7 ENSMUSG00000020185.10 E2f7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f7mm10_v2_chr10_+_110745433_1107455720.689.0e-07Click!


Activity profile for motif E2f7.

activity profile for motif E2f7


Sorted Z-values histogram for motif E2f7

Sorted Z-values for motif E2f7



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f7

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 120 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_116308241 21.972 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr9_+_3013140 20.089 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3037111 19.968 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3025417 17.559 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3017408 15.002 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3015654 14.551 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr4_+_108579445 11.275 ENSMUST00000102744.3
 Orc1
origin recognition complex, subunit 1
chr2_+_72476159 10.104 ENSMUST00000102691.4
 Cdca7
cell division cycle associated 7
chr10_-_69352886 9.417 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1

chr15_+_102296256 9.258 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr8_+_75109528 8.789 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr2_+_72476225 8.750 ENSMUST00000157019.1
 Cdca7
cell division cycle associated 7
chr11_+_102248842 8.728 ENSMUST00000100392.4
 BC030867
cDNA sequence BC030867
chr12_+_24708984 8.689 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr13_-_100775844 7.880 ENSMUST00000075550.3
 Cenph
centromere protein H
chr10_+_3973086 7.232 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr12_+_24708241 7.165 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr2_-_36104060 7.080 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chr13_+_23581563 6.606 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr4_+_132768325 6.552 ENSMUST00000102561.4
 Rpa2
replication protein A2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 22.9 GO:0006342 chromatin silencing(GO:0006342)
3.7 22.0 GO:0045218 zonula adherens maintenance(GO:0045218)
0.9 15.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.4 12.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
2.8 11.3 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.9 10.6 GO:0002227 innate immune response in mucosa(GO:0002227)
0.7 9.3 GO:0000212 meiotic spindle organization(GO:0000212)
0.6 9.1 GO:0000076 DNA replication checkpoint(GO:0000076)
0.3 8.8 GO:0006270 DNA replication initiation(GO:0006270)
0.8 8.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.8 7.4 GO:0090166 Golgi disassembly(GO:0090166)
1.4 7.2 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
1.2 7.1 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.3 6.6 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 6.2 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.2 5.9 GO:0090224 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.2 5.8 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.8 5.6 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.2 5.6 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.1 5.3 GO:0032781 positive regulation of ATPase activity(GO:0032781)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 31.4 GO:0000786 nucleosome(GO:0000786)
2.0 22.0 GO:0005915 zonula adherens(GO:0005915)
0.2 19.8 GO:0072686 mitotic spindle(GO:0072686)
3.2 15.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
2.0 15.6 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.7 10.4 GO:0042555 MCM complex(GO:0042555)
0.0 10.2 GO:0005730 nucleolus(GO:0005730)
0.1 9.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.5 6.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 6.3 GO:0000790 nuclear chromatin(GO:0000790)
0.1 6.1 GO:0000922 spindle pole(GO:0000922)
0.0 5.3 GO:0005667 transcription factor complex(GO:0005667)
1.7 5.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.2 4.8 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.7 4.0 GO:0031298 replication fork protection complex(GO:0031298)
0.1 3.9 GO:0005871 kinesin complex(GO:0005871)
1.2 3.7 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.2 3.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3 3.6 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.4 3.1 GO:0005638 lamin filament(GO:0005638)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 56.4 GO:0003677 DNA binding(GO:0003677)
2.0 24.0 GO:0070097 delta-catenin binding(GO:0070097)
3.2 15.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.9 13.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 11.5 GO:0042393 histone binding(GO:0042393)
0.5 8.2 GO:0035173 histone kinase activity(GO:0035173)
0.0 7.7 GO:0031072 heat shock protein binding(GO:0031072)
1.8 7.2 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.1 6.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 6.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.5 6.4 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.2 6.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.4 5.8 GO:0030957 Tat protein binding(GO:0030957)
0.6 5.2 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1 5.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.8 5.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.7 4.8 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.6 4.5 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 4.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.8 3.9 GO:0043515 kinetochore binding(GO:0043515)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 33.4 PID_E2F_PATHWAY E2F transcription factor network
0.4 22.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.4 20.0 PID_ATR_PATHWAY ATR signaling pathway
0.2 17.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
1.4 12.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 6.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.5 5.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 3.7 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 3.7 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 3.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 2.7 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 1.9 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.6 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 1.4 PID_ATM_PATHWAY ATM pathway
0.0 0.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 27.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
2.1 20.7 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
1.1 17.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
1.1 15.9 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.2 11.7 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.5 11.5 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 6.6 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.4 6.2 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
2.8 5.6 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 5.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 3.9 REACTOME_KINESINS Genes involved in Kinesins
0.2 3.7 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.4 3.6 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.4 3.1 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 3.1 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.3 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.3 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import