Motif ID: E2f8

Z-value: 1.875


Transcription factors associated with E2f8:

Gene SymbolEntrez IDGene Name
E2f8 ENSMUSG00000046179.11 E2f8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f8mm10_v2_chr7_-_48881596_488816190.951.3e-20Click!


Activity profile for motif E2f8.

activity profile for motif E2f8


Sorted Z-values histogram for motif E2f8

Sorted Z-values for motif E2f8



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f8

PNG image of the network

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Top targets:


Showing 1 to 20 of 82 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_89302545 22.034 ENSMUST00000061728.3
 Nog
noggin
chr8_+_75109528 16.064 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr17_+_56040350 12.445 ENSMUST00000002914.8
 Chaf1a
chromatin assembly factor 1, subunit A (p150)
chr17_+_56303321 12.025 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr11_+_26387194 11.016 ENSMUST00000109509.1
ENSMUST00000136830.1
 Fancl

Fanconi anemia, complementation group L

chr9_-_36726374 10.210 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr17_+_56303396 10.162 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr2_-_34913976 10.101 ENSMUST00000028232.3
 Phf19
PHD finger protein 19
chr16_-_46496955 9.911 ENSMUST00000023335.6
ENSMUST00000023334.8
 Pvrl3

poliovirus receptor-related 3

chr16_-_46496772 9.803 ENSMUST00000149901.1
ENSMUST00000096052.2
 Pvrl3

poliovirus receptor-related 3

chr12_+_24708984 9.620 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr1_-_128359610 9.308 ENSMUST00000027601.4
 Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr11_+_98907801 9.250 ENSMUST00000092706.6
 Cdc6
cell division cycle 6
chr7_-_48881032 9.101 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8
chr6_-_94700137 9.086 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr7_-_27337667 8.686 ENSMUST00000038618.6
ENSMUST00000108369.2
 Ltbp4

latent transforming growth factor beta binding protein 4

chr16_-_18811615 8.309 ENSMUST00000096990.3
 Cdc45
cell division cycle 45
chr7_-_48881596 8.193 ENSMUST00000119223.1
 E2f8
E2F transcription factor 8
chr7_-_115824699 8.169 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr6_-_88898664 7.963 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 34.3 GO:0010216 maintenance of DNA methylation(GO:0010216)
1.1 29.1 GO:0006270 DNA replication initiation(GO:0006270)
2.3 23.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
5.5 22.0 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
5.8 17.3 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
1.0 17.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.3 13.0 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.4 12.4 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 10.4 GO:0007276 gamete generation(GO:0007276)
1.4 10.1 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
3.0 9.1 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 8.7 GO:0007179 transforming growth factor beta receptor signaling pathway(GO:0007179)
1.1 8.6 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
2.8 8.3 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.7 8.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.5 7.9 GO:0051571 positive regulation of histone H3-K4 methylation(GO:0051571)
0.3 7.6 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 7.5 GO:0090307 mitotic spindle assembly(GO:0090307)
1.7 7.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
1.1 6.8 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 39.4 GO:0005657 replication fork(GO:0005657)
2.5 37.7 GO:0042555 MCM complex(GO:0042555)
0.1 28.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 18.8 GO:0030424 axon(GO:0030424)
3.4 17.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 14.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
4.1 12.4 GO:0033186 CAF-1 complex(GO:0033186)
0.4 12.1 GO:0005721 pericentric heterochromatin(GO:0005721)
1.0 11.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
1.2 8.6 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
2.8 8.3 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
1.3 7.6 GO:0005663 DNA replication factor C complex(GO:0005663)
1.5 7.5 GO:0031523 Myb complex(GO:0031523)
0.1 7.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
2.4 7.2 GO:1990423 RZZ complex(GO:1990423)
0.2 7.1 GO:0051233 spindle midzone(GO:0051233)
1.4 7.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 6.8 GO:0016607 nuclear speck(GO:0016607)
2.2 6.6 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.3 6.1 GO:0035098 ESC/E(Z) complex(GO:0035098)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 32.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 25.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
5.5 22.2 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.4 21.0 GO:0019955 cytokine binding(GO:0019955)
3.4 17.2 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.4 15.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
1.6 12.4 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 12.1 GO:0004386 helicase activity(GO:0004386)
0.0 11.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.3 10.7 GO:0017025 TBP-class protein binding(GO:0017025)
3.4 10.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 9.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.4 8.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
2.9 8.6 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.1 8.5 GO:0035064 methylated histone binding(GO:0035064)
2.0 7.9 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.7 7.6 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.6 7.6 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
1.2 7.5 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 7.0 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 33.3 PID_E2F_PATHWAY E2F transcription factor network
0.6 28.6 PID_ATR_PATHWAY ATR signaling pathway
0.5 19.7 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.4 18.5 PID_BMP_PATHWAY BMP receptor signaling
1.7 15.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 14.0 PID_CMYB_PATHWAY C-MYB transcription factor network
0.3 12.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.4 11.0 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.2 9.1 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 8.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 7.6 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.1 6.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 5.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 4.2 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 3.5 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 2.0 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 1.1 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 0.6 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 47.8 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
1.7 30.4 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.7 22.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
1.6 21.2 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
0.6 19.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
1.7 15.3 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.7 11.8 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.5 11.0 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.1 9.1 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.7 8.6 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 7.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 3.7 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.2 3.5 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.2 2.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 2.5 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 1.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.0 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.4 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling