Motif ID: Ebf3

Z-value: 1.200


Transcription factors associated with Ebf3:

Gene SymbolEntrez IDGene Name
Ebf3 ENSMUSG00000010476.7 Ebf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ebf3mm10_v2_chr7_-_137314394_137314445-0.508.6e-04Click!


Activity profile for motif Ebf3.

activity profile for motif Ebf3


Sorted Z-values histogram for motif Ebf3

Sorted Z-values for motif Ebf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Ebf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66812593 11.761 ENSMUST00000100572.3
 Sla
src-like adaptor
chr5_+_117781017 7.595 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr1_-_56969827 5.357 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969864 5.266 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr7_+_123982799 3.764 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr4_-_129121234 3.695 ENSMUST00000030572.3
 Hpca
hippocalcin
chr2_-_118703963 3.564 ENSMUST00000104937.1
 Ankrd63
ankyrin repeat domain 63
chr11_+_104231465 3.215 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr11_+_104231573 3.206 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr4_-_129121699 3.117 ENSMUST00000135763.1
ENSMUST00000149763.1
ENSMUST00000164649.1
 Hpca


hippocalcin


chr9_+_89909775 3.073 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr11_+_104231515 2.962 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr1_-_154725920 2.949 ENSMUST00000004214.8
 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr15_-_98677451 2.833 ENSMUST00000120997.1
ENSMUST00000109149.2
ENSMUST00000003451.4
 Rnd1


Rho family GTPase 1


chr15_+_99224976 2.813 ENSMUST00000041415.3
 Kcnh3
potassium voltage-gated channel, subfamily H (eag-related), member 3
chr1_-_193370260 2.732 ENSMUST00000016323.4
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr5_-_139130159 2.732 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr3_+_26331150 2.730 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chr1_-_193370225 2.693 ENSMUST00000169907.1
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr1_+_75400070 2.617 ENSMUST00000113589.1
 Speg
SPEG complex locus

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 133 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 13.2 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.7 10.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 10.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
2.5 7.6 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
2.3 6.8 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.0 5.4 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.4 5.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.8 4.8 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.2 3.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.2 3.1 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.6 2.9 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.5 2.8 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 2.6 GO:0055013 cardiac muscle cell development(GO:0055013)
0.3 2.5 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.8 2.4 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.3 2.4 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.6 2.2 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.4 2.2 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.4 2.2 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.3 2.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
1.2 11.6 GO:0045298 tubulin complex(GO:0045298)
0.1 9.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.7 7.6 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.5 6.8 GO:0044327 dendritic spine head(GO:0044327)
0.4 5.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 4.8 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 4.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 3.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 3.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 2.8 GO:0031941 filamentous actin(GO:0031941)
0.0 2.8 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 2.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 2.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.7 2.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.7 2.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.4 2.2 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.1 1.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.6 1.8 GO:0045160 myosin I complex(GO:0045160)
0.2 1.7 GO:0098576 lumenal side of membrane(GO:0098576)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.7 11.6 GO:0099609 microtubule lateral binding(GO:0099609)
0.0 8.9 GO:0003682 chromatin binding(GO:0003682)
2.5 7.6 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 5.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 5.5 GO:0003779 actin binding(GO:0003779)
0.5 5.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 5.1 GO:0005080 protein kinase C binding(GO:0005080)
0.1 3.9 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 3.4 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.2 3.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.5 2.8 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.3 2.6 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.4 2.5 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.5 2.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 2.3 GO:0070888 E-box binding(GO:0070888)
0.0 2.3 GO:0005125 cytokine activity(GO:0005125)
0.0 2.3 GO:0030165 PDZ domain binding(GO:0030165)
0.4 2.2 GO:0097643 amylin receptor activity(GO:0097643)
0.2 2.2 GO:0017154 semaphorin receptor activity(GO:0017154)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.6 11.6 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 6.9 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 5.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.3 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 3.3 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 2.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 2.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.4 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 2.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.4 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.3 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.1 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.9 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.9 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 0.8 PID_RB_1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 10.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.4 7.7 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 6.9 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 5.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 5.1 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.3 4.8 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 3.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 2.9 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.4 2.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 2.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.7 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 2.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 2.1 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 1.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.7 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 1.6 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.1 1.5 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 1.3 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.2 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis