Motif ID: Egr1

Z-value: 2.201


Transcription factors associated with Egr1:

Gene SymbolEntrez IDGene Name
Egr1 ENSMUSG00000038418.7 Egr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr1mm10_v2_chr18_+_34861200_34861215-0.095.8e-01Click!


Activity profile for motif Egr1.

activity profile for motif Egr1


Sorted Z-values histogram for motif Egr1

Sorted Z-values for motif Egr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_6065538 24.893 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr14_-_33447142 12.424 ENSMUST00000111944.3
ENSMUST00000022504.5
ENSMUST00000111945.2
 Mapk8


mitogen-activated protein kinase 8


chr5_-_139130159 10.303 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr5_-_139129662 10.225 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr11_+_98348404 9.227 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr14_-_102982630 8.221 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr7_+_73740277 7.937 ENSMUST00000107456.2
 Fam174b
family with sequence similarity 174, member B
chr2_+_157914618 7.893 ENSMUST00000109523.1
 Vstm2l
V-set and transmembrane domain containing 2-like
chr11_-_6065737 7.821 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr4_+_127169131 7.626 ENSMUST00000046659.7
 Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr5_+_137553517 7.500 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
 Actl6b




actin-like 6B




chr7_-_27396542 7.323 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4
chr7_+_82175156 7.125 ENSMUST00000180243.1
 Sh3gl3
SH3-domain GRB2-like 3
chr7_+_82174796 6.841 ENSMUST00000032874.7
 Sh3gl3
SH3-domain GRB2-like 3
chr5_+_137288273 6.822 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chrX_-_20920911 6.606 ENSMUST00000081893.6
ENSMUST00000115345.1
 Syn1

synapsin I

chr9_+_59750876 6.288 ENSMUST00000136740.1
ENSMUST00000135298.1
ENSMUST00000128341.1
 Myo9a


myosin IXa


chr14_-_30353468 6.273 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr2_-_24763047 6.205 ENSMUST00000100348.3
ENSMUST00000041342.5
ENSMUST00000114447.1
ENSMUST00000102939.2
ENSMUST00000070864.7
 Cacna1b




calcium channel, voltage-dependent, N type, alpha 1B subunit




chr4_-_22488296 6.178 ENSMUST00000178174.1
 Pou3f2
POU domain, class 3, transcription factor 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 243 entries
Log-likelihood per target Total log-likelihoodTermDescription
10.9 32.7 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
1.7 20.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
1.2 15.7 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 15.6 GO:0000209 protein polyubiquitination(GO:0000209)
3.0 14.9 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
3.1 12.4 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
2.1 10.5 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 10.0 GO:0006813 potassium ion transport(GO:0006813)
0.6 9.6 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
3.1 9.2 GO:0007621 negative regulation of female receptivity(GO:0007621)
1.1 8.9 GO:0005513 detection of calcium ion(GO:0005513)
1.1 7.9 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
2.5 7.4 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
1.2 7.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 7.1 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.1 6.9 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
1.1 6.8 GO:0019695 choline metabolic process(GO:0019695)
1.1 6.8 GO:0032796 uropod organization(GO:0032796)
0.1 6.8 GO:0045921 positive regulation of exocytosis(GO:0045921)
0.7 6.7 GO:0048149 behavioral response to ethanol(GO:0048149)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 31.9 GO:0051233 spindle midzone(GO:0051233)
1.6 21.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 20.0 GO:0005769 early endosome(GO:0005769)
0.3 18.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 15.8 GO:0000139 Golgi membrane(GO:0000139)
0.1 13.8 GO:0055037 recycling endosome(GO:0055037)
0.3 11.6 GO:0002102 podosome(GO:0002102)
0.3 11.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 10.4 GO:0048786 presynaptic active zone(GO:0048786)
1.6 9.8 GO:0008091 spectrin(GO:0008091)
0.0 9.6 GO:0005773 vacuole(GO:0005773)
2.3 9.4 GO:0090537 CERF complex(GO:0090537)
0.3 9.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.5 7.9 GO:1990635 proximal dendrite(GO:1990635)
1.3 7.7 GO:0005955 calcineurin complex(GO:0005955)
0.6 7.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
1.2 7.4 GO:0044305 calyx of Held(GO:0044305)
0.7 6.8 GO:0032426 stereocilium tip(GO:0032426)
0.5 6.8 GO:0043083 synaptic cleft(GO:0043083)
1.7 6.6 GO:0044307 dendritic branch(GO:0044307)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 173 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 38.1 GO:0043274 phospholipase binding(GO:0043274)
1.9 20.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 18.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.2 17.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
3.1 12.4 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
1.0 9.6 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.7 9.6 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
3.1 9.4 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
0.1 9.3 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
3.1 9.2 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.3 8.8 GO:0032183 SUMO binding(GO:0032183)
0.1 8.8 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 8.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 8.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.5 8.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.5 8.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 7.3 GO:0030507 spectrin binding(GO:0030507)
0.3 7.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
1.7 6.8 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.6 6.8 GO:0032036 myosin heavy chain binding(GO:0032036)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 29.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 24.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.4 17.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.3 13.3 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.9 12.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.4 11.6 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.5 9.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.3 7.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 7.2 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 5.7 PID_LKB1_PATHWAY LKB1 signaling events
0.2 5.6 PID_ARF6_PATHWAY Arf6 signaling events
0.1 5.6 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 4.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 4.6 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 4.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 4.3 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 4.2 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.1 3.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 2.8 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 2.2 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 39.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
1.1 25.0 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.4 18.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.6 16.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.8 11.8 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.8 11.6 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.5 10.1 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 9.8 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth
1.4 9.6 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 8.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 8.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.5 8.2 REACTOME_DAG_AND_IP3_SIGNALING Genes involved in DAG and IP3 signaling
0.0 8.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 6.8 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.2 6.1 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.3 5.7 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.4 4.9 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 4.9 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.3 4.7 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 4.0 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis