Motif ID: Egr3

Z-value: 0.653


Transcription factors associated with Egr3:

Gene SymbolEntrez IDGene Name
Egr3 ENSMUSG00000033730.3 Egr3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr3mm10_v2_chr14_+_70077375_700774450.296.4e-02Click!


Activity profile for motif Egr3.

activity profile for motif Egr3


Sorted Z-values histogram for motif Egr3

Sorted Z-values for motif Egr3



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr3

PNG image of the network

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Top targets:


Showing 1 to 20 of 107 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_119184374 3.314 ENSMUST00000084650.4
 Gpr139
G protein-coupled receptor 139
chr7_-_110061319 2.845 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr6_-_49214954 2.498 ENSMUST00000031838.7
 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr17_+_87282880 2.195 ENSMUST00000041110.5
ENSMUST00000125875.1
 Ttc7

tetratricopeptide repeat domain 7

chr9_-_58204310 2.140 ENSMUST00000114144.2
 Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr8_+_62951361 2.013 ENSMUST00000119068.1
 Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr17_-_87282793 1.964 ENSMUST00000146560.2
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr4_-_41695935 1.877 ENSMUST00000145379.1
 Cntfr
ciliary neurotrophic factor receptor
chr17_-_87282771 1.876 ENSMUST00000161759.1
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr9_-_55048544 1.793 ENSMUST00000034854.6
 Chrnb4
cholinergic receptor, nicotinic, beta polypeptide 4
chr11_+_98937669 1.641 ENSMUST00000107475.2
ENSMUST00000068133.3
 Rara

retinoic acid receptor, alpha

chr7_-_144939823 1.612 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr10_+_40883819 1.255 ENSMUST00000105509.1
 Wasf1
WAS protein family, member 1
chr4_+_123183456 1.250 ENSMUST00000126995.1
 Hpcal4
hippocalcin-like 4
chr4_+_123183722 1.230 ENSMUST00000152194.1
 Hpcal4
hippocalcin-like 4
chr10_-_5922341 1.172 ENSMUST00000117676.1
ENSMUST00000019909.7
 Rgs17

regulator of G-protein signaling 17

chrX_+_36195968 1.101 ENSMUST00000115256.1
 Zcchc12
zinc finger, CCHC domain containing 12
chr1_-_156939387 1.060 ENSMUST00000171292.1
 Ralgps2
Ral GEF with PH domain and SH3 binding motif 2
chr12_+_108635743 1.030 ENSMUST00000172409.1
 Evl
Ena-vasodilator stimulated phosphoprotein
chrX_+_143664290 1.002 ENSMUST00000112868.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.0 3.0 GO:0051028 mRNA transport(GO:0051028)
0.0 2.3 GO:0045773 positive regulation of axon extension(GO:0045773)
0.3 2.2 GO:1990416 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.2 2.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 2.2 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.2 2.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.5 1.9 GO:0003360 brainstem development(GO:0003360)
0.6 1.8 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.1 1.8 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.5 1.6 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.2 1.6 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.2 1.1 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.2 1.1 GO:0007403 glial cell fate determination(GO:0007403)
0.2 1.1 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.2 1.0 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.2 1.0 GO:0070166 enamel mineralization(GO:0070166)
0.3 0.9 GO:0060023 soft palate development(GO:0060023)
0.2 0.9 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.9 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.2 GO:0031209 SCAR complex(GO:0031209)
0.1 2.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.6 1.9 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.2 1.8 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 1.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.5 GO:0042825 TAP complex(GO:0042825)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.3 GO:0031417 NatC complex(GO:0031417)
0.0 0.3 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 0.3 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.3 GO:0031430 M band(GO:0031430)
0.0 0.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.2 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:0032156 septin cytoskeleton(GO:0032156)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 3.3 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 2.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 2.5 GO:0030507 spectrin binding(GO:0030507)
0.0 2.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 2.1 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 2.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 1.9 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.2 1.8 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 1.6 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.1 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 1.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 1.0 GO:0005522 profilin binding(GO:0005522)
0.0 1.0 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 0.9 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.2 0.9 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.7 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.0 0.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.2 PID_IFNG_PATHWAY IFN-gamma pathway
0.1 1.1 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.8 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.3 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.1 2.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.0 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.2 1.8 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.0 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 1.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.8 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.6 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.5 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.4 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.3 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport