Motif ID: Egr4

Z-value: 0.621


Transcription factors associated with Egr4:

Gene SymbolEntrez IDGene Name
Egr4 ENSMUSG00000071341.3 Egr4



Activity profile for motif Egr4.

activity profile for motif Egr4


Sorted Z-values histogram for motif Egr4

Sorted Z-values for motif Egr4



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr4

PNG image of the network

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Top targets:


Showing 1 to 20 of 99 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_70851189 4.357 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr13_+_48261427 3.059 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr19_+_25505618 2.675 ENSMUST00000025755.4
 Dmrt1
doublesex and mab-3 related transcription factor 1
chr2_-_102186322 2.264 ENSMUST00000111222.1
ENSMUST00000058790.5
 Ldlrad3

low density lipoprotein receptor class A domain containing 3

chr12_+_17690793 1.983 ENSMUST00000071858.3
 Hpcal1
hippocalcin-like 1
chr11_-_19018956 1.982 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
 Meis1


Meis homeobox 1


chr18_+_35829798 1.679 ENSMUST00000060722.6
 Cxxc5
CXXC finger 5
chr6_+_4747306 1.653 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
 Peg10


paternally expressed 10


chr4_+_128883549 1.616 ENSMUST00000035667.8
 Trim62
tripartite motif-containing 62
chrX_+_36195968 1.563 ENSMUST00000115256.1
 Zcchc12
zinc finger, CCHC domain containing 12
chr11_-_19018714 1.509 ENSMUST00000177417.1
 Meis1
Meis homeobox 1
chr7_+_35119285 1.459 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr9_+_65630552 1.436 ENSMUST00000055844.8
 Rbpms2
RNA binding protein with multiple splicing 2
chr17_-_31658729 1.287 ENSMUST00000166526.1
ENSMUST00000014684.4
 U2af1

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1

chr3_+_135438722 1.283 ENSMUST00000166033.1
 Ube2d3
ubiquitin-conjugating enzyme E2D 3
chrX_+_36195950 1.264 ENSMUST00000115257.1
 Zcchc12
zinc finger, CCHC domain containing 12
chr5_-_149051604 1.246 ENSMUST00000093196.4
 Hmgb1
high mobility group box 1
chrX_+_36195938 1.204 ENSMUST00000048067.3
 Zcchc12
zinc finger, CCHC domain containing 12
chrX_+_36195904 1.190 ENSMUST00000115258.2
 Zcchc12
zinc finger, CCHC domain containing 12
chr11_-_87987528 1.147 ENSMUST00000020775.2
 Dynll2
dynein light chain LC8-type 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 5.2 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.3 4.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 3.5 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.8 3.1 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.4 2.7 GO:0060903 positive regulation of meiosis I(GO:0060903)
0.0 1.9 GO:0070613 regulation of protein processing(GO:0070613)
0.1 1.8 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 1.7 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 1.7 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.1 1.6 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 1.6 GO:0043966 histone H3 acetylation(GO:0043966)
0.2 1.5 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.2 1.4 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 1.4 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 1.3 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.4 1.2 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.1 1.1 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.3 0.9 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.3 0.9 GO:0003100 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) regulation of systemic arterial blood pressure by endothelin(GO:0003100) beta selection(GO:0043366) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.2 0.8 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.6 GO:0016607 nuclear speck(GO:0016607)
0.0 2.3 GO:0001726 ruffle(GO:0001726)
0.5 1.8 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.1 1.6 GO:0030914 STAGA complex(GO:0030914)
0.5 1.5 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.1 1.3 GO:0089701 U2AF(GO:0089701)
0.1 1.1 GO:0016461 unconventional myosin complex(GO:0016461)
0.3 0.8 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.5 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.5 GO:0045298 tubulin complex(GO:0045298)
0.0 0.5 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.5 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.5 GO:0016235 aggresome(GO:0016235)
0.0 0.3 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.3 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.3 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.2 GO:0032183 SUMO binding(GO:0032183)
0.2 4.4 GO:0070410 co-SMAD binding(GO:0070410)
0.0 3.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 3.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 2.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 1.8 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 1.5 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0 1.5 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 1.3 GO:0050733 RS domain binding(GO:0050733)
0.0 1.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.4 1.2 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.0 1.1 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 0.9 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.8 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.8 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.8 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.7 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.7 GO:0035064 methylated histone binding(GO:0035064)
0.2 0.6 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.6 GO:0045131 pre-mRNA branch point binding(GO:0045131)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 4.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.3 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.9 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 0.8 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.6 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.6 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.5 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.7 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.3 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.3 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.0 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.9 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 0.8 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.8 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 0.5 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.5 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)