Motif ID: Elf3

Z-value: 1.027


Transcription factors associated with Elf3:

Gene SymbolEntrez IDGene Name
Elf3 ENSMUSG00000003051.7 Elf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elf3mm10_v2_chr1_-_135258449_1352584720.443.8e-03Click!


Activity profile for motif Elf3.

activity profile for motif Elf3


Sorted Z-values histogram for motif Elf3

Sorted Z-values for motif Elf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Elf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_55419898 6.022 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr11_+_78324200 5.100 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr14_-_70207637 4.844 ENSMUST00000022682.5
 Sorbs3
sorbin and SH3 domain containing 3
chr15_+_79516396 4.239 ENSMUST00000010974.7
 Kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr11_+_115163333 3.819 ENSMUST00000021077.3
 Slc9a3r1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr4_-_14621805 3.446 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr6_+_15720654 3.416 ENSMUST00000101663.3
 Mdfic
MyoD family inhibitor domain containing
chr14_-_54577578 3.398 ENSMUST00000054487.8
 Ajuba
ajuba LIM protein
chr2_+_164562579 3.304 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr17_+_35049966 3.230 ENSMUST00000007257.9
 Clic1
chloride intracellular channel 1
chr19_-_50678642 2.853 ENSMUST00000072685.6
ENSMUST00000164039.2
 Sorcs1

VPS10 domain receptor protein SORCS 1

chr11_+_61653259 2.846 ENSMUST00000004959.2
 Grap
GRB2-related adaptor protein
chr12_-_65172560 2.725 ENSMUST00000052201.8
 Mis18bp1
MIS18 binding protein 1
chr6_+_15721087 2.708 ENSMUST00000120512.1
 Mdfic
MyoD family inhibitor domain containing
chr19_-_50678485 2.703 ENSMUST00000111756.3
 Sorcs1
VPS10 domain receptor protein SORCS 1
chr11_-_48816936 2.640 ENSMUST00000140800.1
 Trim41
tripartite motif-containing 41
chr10_-_83648713 2.524 ENSMUST00000020500.7
 Appl2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr1_+_51987139 2.473 ENSMUST00000168302.1
 Stat4
signal transducer and activator of transcription 4
chr19_+_16435616 2.360 ENSMUST00000025602.2
 Gna14
guanine nucleotide binding protein, alpha 14
chr5_+_110330697 2.321 ENSMUST00000112481.1
 Pole
polymerase (DNA directed), epsilon

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.7 GO:0019532 oxalate transport(GO:0019532)
0.3 6.5 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.2 6.0 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.5 5.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.4 4.2 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.6 4.2 GO:0006621 protein retention in ER lumen(GO:0006621)
1.3 3.8 GO:0042939 glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
0.1 3.8 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.9 3.5 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.5 3.4 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 3.2 GO:1902476 chloride transmembrane transport(GO:1902476)
0.3 3.1 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.1 2.7 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.4 2.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.4 2.5 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.6 2.4 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.8 2.3 GO:0045004 DNA replication proofreading(GO:0045004)
0.3 2.1 GO:0071361 cellular response to ethanol(GO:0071361)
0.1 2.1 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.5 2.0 GO:0001920 negative regulation of receptor recycling(GO:0001920) negative regulation of low-density lipoprotein particle clearance(GO:0010989) positive regulation of low-density lipoprotein particle receptor catabolic process(GO:0032805)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 GO:0016323 basolateral plasma membrane(GO:0016323)
1.5 6.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 3.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 3.9 GO:0072562 blood microparticle(GO:0072562)
0.3 3.8 GO:0032426 stereocilium tip(GO:0032426)
0.1 3.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 3.2 GO:0034707 chloride channel complex(GO:0034707)
1.0 3.1 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.1 3.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 2.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 2.7 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.9 2.6 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 2.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.5 2.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 2.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 2.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 2.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.7 2.0 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.2 2.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 1.7 GO:0005682 U5 snRNP(GO:0005682)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.6 6.7 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 6.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 5.8 GO:0017166 vinculin binding(GO:0017166)
0.0 5.8 GO:0030165 PDZ domain binding(GO:0030165)
0.3 5.6 GO:0030957 Tat protein binding(GO:0030957)
0.8 5.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.1 4.2 GO:0046923 ER retention sequence binding(GO:0046923)
0.3 3.8 GO:0017081 chloride channel regulator activity(GO:0017081)
0.3 3.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.7 3.3 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.1 3.2 GO:0005254 chloride channel activity(GO:0005254)
0.8 3.1 GO:0035877 death effector domain binding(GO:0035877)
0.3 2.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 2.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.8 2.3 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 2.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 2.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.7 2.0 GO:0034190 very-low-density lipoprotein particle binding(GO:0034189) apolipoprotein receptor binding(GO:0034190)
0.1 1.8 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 6.7 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 6.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 3.8 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.3 3.1 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 2.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 2.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 2.1 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 2.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.0 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.4 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 1.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.3 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.0 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.8 ST_GAQ_PATHWAY G alpha q Pathway
0.1 0.7 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.7 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 5.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 4.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 4.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 4.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 4.4 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.2 4.2 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 3.9 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 3.1 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.2 2.9 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 2.8 REACTOME_SIGNALING_BY_SCF_KIT Genes involved in Signaling by SCF-KIT
0.0 2.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 2.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.3 2.4 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3 2.1 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.3 1.7 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 1.7 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2 1.5 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.4 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1