Motif ID: Emx1_Emx2

Z-value: 0.587

Transcription factors associated with Emx1_Emx2:

Gene SymbolEntrez IDGene Name
Emx1 ENSMUSG00000033726.8 Emx1
Emx2 ENSMUSG00000043969.4 Emx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Emx2mm10_v2_chr19_+_59458372_59458450-0.305.3e-02Click!
Emx1mm10_v2_chr6_+_85187438_85187510-0.153.4e-01Click!


Activity profile for motif Emx1_Emx2.

activity profile for motif Emx1_Emx2


Sorted Z-values histogram for motif Emx1_Emx2

Sorted Z-values for motif Emx1_Emx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Emx1_Emx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 173 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_118961578 4.017 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr7_-_103827922 3.187 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr4_-_82505749 3.008 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr4_-_82505274 2.672 ENSMUST00000050872.8
ENSMUST00000064770.2
 Nfib

nuclear factor I/B

chr17_-_36032682 2.324 ENSMUST00000102678.4
 H2-T23
histocompatibility 2, T region locus 23
chr4_-_82505707 2.107 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr10_+_81257277 2.067 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
 Matk


megakaryocyte-associated tyrosine kinase


chr10_+_90071095 1.822 ENSMUST00000183109.1
 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr7_-_142661858 1.652 ENSMUST00000145896.2
 Igf2
insulin-like growth factor 2
chr16_-_26371828 1.622 ENSMUST00000023154.2
 Cldn1
claudin 1
chr8_-_21906412 1.466 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr7_+_126781483 1.407 ENSMUST00000172352.1
ENSMUST00000094037.4
 Tbx6

T-box 6

chr2_-_160619971 1.339 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chrX_+_8271133 1.271 ENSMUST00000127103.1
ENSMUST00000115591.1
 Slc38a5

solute carrier family 38, member 5

chr13_-_97747373 1.242 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr3_+_121953213 1.146 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr11_+_109543694 1.055 ENSMUST00000106696.1
 Arsg
arylsulfatase G
chr3_+_137341103 1.008 ENSMUST00000119475.1
 Emcn
endomucin
chr13_-_97747399 0.968 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_-_158356258 0.926 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 7.8 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 3.2 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.8 2.3 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.0 2.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 1.8 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.2 1.7 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.5 1.6 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.0 1.5 GO:0042742 defense response to bacterium(GO:0042742)
0.2 1.4 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.1 1.3 GO:0015816 glycine transport(GO:0015816)
0.0 0.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.9 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.3 0.8 GO:2000016 negative regulation of determination of dorsal identity(GO:2000016)
0.2 0.8 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.2 0.8 GO:0070295 renal water absorption(GO:0070295)
0.1 0.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.7 GO:0036159 outer dynein arm assembly(GO:0036158) inner dynein arm assembly(GO:0036159)
0.2 0.6 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.2 0.6 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.1 0.6 GO:0035609 C-terminal protein deglutamylation(GO:0035609)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.8 3.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 2.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 1.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.8 GO:0030315 T-tubule(GO:0030315)
0.0 0.7 GO:0005922 connexon complex(GO:0005922)
0.2 0.6 GO:0043512 inhibin A complex(GO:0043512)
0.0 0.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.4 GO:0070469 respiratory chain(GO:0070469)
0.1 0.3 GO:0031362 intrinsic component of external side of plasma membrane(GO:0031233) anchored component of external side of plasma membrane(GO:0031362)
0.1 0.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.3 4.0 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.8 3.2 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.3 2.3 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 2.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 1.7 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 1.6 GO:0001618 virus receptor activity(GO:0001618)
0.1 1.3 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 1.1 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 1.0 GO:0004601 peroxidase activity(GO:0004601)
0.0 1.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.8 GO:0098821 BMP receptor activity(GO:0098821)
0.1 0.8 GO:0015288 porin activity(GO:0015288)
0.0 0.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 0.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 0.6 GO:0098809 nitrite reductase activity(GO:0098809)
0.1 0.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 2.3 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.9 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 1.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.8 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.4 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.8 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 2.3 REACTOME_SIGNALING_BY_ERBB2 Genes involved in Signaling by ERBB2
0.1 1.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.3 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.1 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 0.8 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 0.7 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 0.7 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 0.6 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.6 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.6 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.6 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.6 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.2 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.2 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter