Motif ID: En1

Z-value: 0.669


Transcription factors associated with En1:

Gene SymbolEntrez IDGene Name
En1 ENSMUSG00000058665.7 En1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En1mm10_v2_chr1_+_120602405_120602418-0.202.1e-01Click!


Activity profile for motif En1.

activity profile for motif En1


Sorted Z-values histogram for motif En1

Sorted Z-values for motif En1



Network of associatons between targets according to the STRING database.



First level regulatory network of En1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_67234620 4.977 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr6_-_23248264 4.546 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr16_-_26989974 3.263 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr1_+_6487231 3.242 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr19_+_60144682 3.015 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr1_-_158814469 2.365 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr12_+_109453455 2.193 ENSMUST00000109844.4
ENSMUST00000109842.2
ENSMUST00000109843.1
ENSMUST00000109846.4
ENSMUST00000173539.1
ENSMUST00000109841.2
 Dlk1





delta-like 1 homolog (Drosophila)





chr19_+_47014672 2.081 ENSMUST00000037636.3
 Ina
internexin neuronal intermediate filament protein, alpha
chr15_-_56694525 1.919 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr1_+_72824482 1.886 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr16_-_59555752 1.760 ENSMUST00000179383.1
ENSMUST00000044604.8
 Crybg3

beta-gamma crystallin domain containing 3

chr15_-_85581809 1.723 ENSMUST00000023015.7
 Wnt7b
wingless-related MMTV integration site 7B
chr16_-_45953565 1.665 ENSMUST00000134802.1
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr6_+_4755327 1.644 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr12_+_109452833 1.545 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr5_+_92925400 1.490 ENSMUST00000172706.1
 Shroom3
shroom family member 3
chr17_+_35841668 1.461 ENSMUST00000174124.1
 Mdc1
mediator of DNA damage checkpoint 1
chr4_-_129227883 1.353 ENSMUST00000106051.1
 C77080
expressed sequence C77080
chr11_-_77725281 1.351 ENSMUST00000078623.4
 Cryba1
crystallin, beta A1
chr1_-_87156127 1.310 ENSMUST00000160810.1
 Ecel1
endothelin converting enzyme-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.0 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.8 4.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.6 4.0 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 3.7 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1 3.3 GO:0006270 DNA replication initiation(GO:0006270)
0.3 3.2 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 2.5 GO:0060349 bone morphogenesis(GO:0060349)
0.0 2.1 GO:0045773 positive regulation of axon extension(GO:0045773)
0.5 1.9 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2 1.9 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.9 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 1.8 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.6 1.7 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.1 1.7 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.3 1.6 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.2 1.5 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 1.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.2 1.4 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 1.4 GO:0003016 respiratory system process(GO:0003016)
0.4 1.3 GO:1904274 tricellular tight junction assembly(GO:1904274)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.0 GO:0045180 basal cortex(GO:0045180)
0.0 2.9 GO:0032993 protein-DNA complex(GO:0032993)
0.2 2.1 GO:0005883 neurofilament(GO:0005883)
0.0 2.0 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 1.6 GO:0005657 replication fork(GO:0005657)
0.0 1.6 GO:0005814 centriole(GO:0005814)
0.1 1.4 GO:0045277 respiratory chain complex IV(GO:0045277)
0.2 1.3 GO:0061689 tricellular tight junction(GO:0061689)
0.0 1.1 GO:0005811 lipid particle(GO:0005811)
0.1 1.0 GO:0000145 exocyst(GO:0000145)
0.0 1.0 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.3 0.9 GO:1990047 spindle matrix(GO:1990047)
0.2 0.9 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.9 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.9 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.9 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.9 GO:0016235 aggresome(GO:0016235)
0.2 0.8 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 3.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 3.2 GO:0001047 core promoter binding(GO:0001047)
0.6 1.9 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.3 1.9 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 1.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.4 1.7 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.0 1.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.5 1.6 GO:0033680 ATP-dependent DNA/RNA helicase activity(GO:0033680)
0.2 1.5 GO:0005042 netrin receptor activity(GO:0005042)
0.2 1.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.3 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.1 1.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.2 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 1.2 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.2 GO:0008308 voltage-gated anion channel activity(GO:0008308)
0.0 1.2 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 1.2 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 1.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.7 PID_ATM_PATHWAY ATM pathway
0.0 1.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.3 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.0 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 0.8 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.8 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.6 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 0.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.5 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 0.4 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.4 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.3 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 4.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.9 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 1.7 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 1.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.6 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.5 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.1 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 1.0 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.9 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.8 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.8 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.8 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 0.7 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.7 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 0.6 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors