Motif ID: Epas1_Bcl3

Z-value: 1.637

Transcription factors associated with Epas1_Bcl3:

Gene SymbolEntrez IDGene Name
Bcl3 ENSMUSG00000053175.10 Bcl3
Epas1 ENSMUSG00000024140.9 Epas1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Epas1mm10_v2_chr17_+_86753900_867539140.163.1e-01Click!


Activity profile for motif Epas1_Bcl3.

activity profile for motif Epas1_Bcl3


Sorted Z-values histogram for motif Epas1_Bcl3

Sorted Z-values for motif Epas1_Bcl3



Network of associatons between targets according to the STRING database.



First level regulatory network of Epas1_Bcl3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_60177482 13.294 ENSMUST00000140924.1
 Atp8a2
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
chr17_+_48932368 12.671 ENSMUST00000046254.2
 Lrfn2
leucine rich repeat and fibronectin type III domain containing 2
chr2_+_169632996 10.208 ENSMUST00000109159.2
 Tshz2
teashirt zinc finger family member 2
chr4_-_20778527 8.879 ENSMUST00000119374.1
 Nkain3
Na+/K+ transporting ATPase interacting 3
chr8_-_48555846 8.756 ENSMUST00000110345.1
ENSMUST00000110343.1
 Tenm3

teneurin transmembrane protein 3

chr19_+_23758819 8.218 ENSMUST00000025830.7
 Apba1
amyloid beta (A4) precursor protein binding, family A, member 1
chr12_-_14152038 8.089 ENSMUST00000020926.6
 Fam84a
family with sequence similarity 84, member A
chr4_+_48045144 7.773 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr5_-_128953303 7.309 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chr12_-_67221221 7.036 ENSMUST00000178814.1
ENSMUST00000179345.2
 Mdga2
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr18_-_25753852 6.958 ENSMUST00000025117.6
ENSMUST00000115816.2
 Celf4

CUGBP, Elav-like family member 4

chr5_+_27261916 6.767 ENSMUST00000101471.3
 Dpp6
dipeptidylpeptidase 6
chr3_-_80802789 6.552 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr17_+_86167777 6.218 ENSMUST00000097275.2
 Prkce
protein kinase C, epsilon
chr15_+_82275197 6.156 ENSMUST00000116423.1
 Sept3
septin 3
chr7_-_27446599 5.999 ENSMUST00000011895.7
 Sptbn4
spectrin beta, non-erythrocytic 4
chr2_-_113217051 5.874 ENSMUST00000080673.5
 Ryr3
ryanodine receptor 3
chr4_+_123183722 5.872 ENSMUST00000152194.1
 Hpcal4
hippocalcin-like 4
chr2_+_4300462 5.815 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr12_+_61523889 5.762 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 15.0 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1 11.9 GO:0002028 regulation of sodium ion transport(GO:0002028)
1.3 10.5 GO:0097264 self proteolysis(GO:0097264)
1.6 9.3 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 9.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 8.3 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.5 8.2 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
2.6 7.8 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.9 7.7 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.8 7.4 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.6 7.4 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.4 7.2 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.2 7.2 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
0.5 7.0 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.2 7.0 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.2 6.6 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
1.6 6.2 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
1.0 6.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.2 5.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 5.3 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 18.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 17.8 GO:0045202 synapse(GO:0045202)
0.0 14.8 GO:0042995 cell projection(GO:0042995)
0.1 14.0 GO:0008021 synaptic vesicle(GO:0008021)
0.1 12.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.5 10.8 GO:0032279 asymmetric synapse(GO:0032279)
0.0 9.6 GO:0000139 Golgi membrane(GO:0000139)
0.6 9.3 GO:0031143 pseudopodium(GO:0031143)
0.3 7.7 GO:0031430 M band(GO:0031430)
0.1 7.4 GO:0043679 axon terminus(GO:0043679)
0.2 7.2 GO:0097440 apical dendrite(GO:0097440)
0.8 7.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
1.5 6.2 GO:0099569 presynaptic cytoskeleton(GO:0099569)
1.0 6.0 GO:0008091 spectrin(GO:0008091)
1.2 5.9 GO:0030314 junctional membrane complex(GO:0030314)
0.1 5.7 GO:0005901 caveola(GO:0005901)
0.0 5.3 GO:0005923 bicellular tight junction(GO:0005923)
0.1 5.1 GO:0043204 perikaryon(GO:0043204)
1.7 5.0 GO:0043512 inhibin A complex(GO:0043512)
0.1 5.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.6 GO:0030507 spectrin binding(GO:0030507)
0.6 15.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 12.3 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 11.9 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.3 10.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 10.1 GO:0015459 potassium channel regulator activity(GO:0015459)
3.1 9.3 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.0 7.9 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.2 7.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 7.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.3 7.6 GO:0005272 sodium channel activity(GO:0005272)
0.1 7.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.9 7.0 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 7.0 GO:0005096 GTPase activator activity(GO:0005096)
0.9 6.6 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.2 6.5 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114)
1.6 6.2 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
2.0 5.9 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.3 5.7 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.9 5.2 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 18.2 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.3 7.8 ST_GA12_PATHWAY G alpha 12 Pathway
0.2 6.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 6.8 PID_LKB1_PATHWAY LKB1 signaling events
0.1 5.7 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 4.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 4.6 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 3.7 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 2.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 2.3 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 2.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 2.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 1.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.3 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.9 PID_E2F_PATHWAY E2F transcription factor network
0.2 0.8 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.1 0.8 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.7 PID_FAS_PATHWAY FAS (CD95) signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 15.0 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.3 11.0 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.8 10.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 10.1 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.3 7.4 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 6.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 6.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 5.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
1.3 5.0 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.4 4.7 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 4.7 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 4.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.3 3.8 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 3.8 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 3.8 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 3.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.3 3.5 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 3.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 3.5 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels