Motif ID: Erg
Z-value: 1.213
Transcription factors associated with Erg:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Erg | ENSMUSG00000040732.12 | Erg |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Erg | mm10_v2_chr16_-_95459245_95459384 | 0.36 | 2.2e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 215 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 15.2 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.9 | 13.7 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.3 | 10.6 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.2 | 6.8 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.3 | 6.2 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.4 | 5.3 | GO:0070932 | histone H3 deacetylation(GO:0070932) |
| 0.2 | 5.3 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 1.6 | 4.9 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
| 0.7 | 4.7 | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
| 0.1 | 4.1 | GO:0001937 | negative regulation of endothelial cell proliferation(GO:0001937) |
| 0.5 | 4.0 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.4 | 4.0 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
| 0.8 | 3.9 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.1 | 3.9 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.8 | 3.8 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994) |
| 0.4 | 3.8 | GO:2001054 | negative regulation of mesenchymal cell apoptotic process(GO:2001054) |
| 0.4 | 3.6 | GO:0060662 | tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662) |
| 0.4 | 3.6 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.0 | 3.4 | GO:0014013 | regulation of gliogenesis(GO:0014013) |
| 0.7 | 3.3 | GO:0032497 | detection of lipopolysaccharide(GO:0032497) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 99 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 24.5 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 8.5 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 7.9 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.1 | 7.2 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 6.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 6.3 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 5.9 | GO:0001726 | ruffle(GO:0001726) |
| 0.1 | 5.1 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 5.0 | GO:0005884 | actin filament(GO:0005884) |
| 1.2 | 4.9 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 1.2 | 4.6 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.4 | 3.9 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.2 | 3.9 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.6 | 3.3 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.2 | 3.1 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.6 | 3.0 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.3 | 2.8 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.0 | 2.8 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.1 | 2.5 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 2.4 | GO:0016459 | myosin complex(GO:0016459) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 136 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.7 | GO:0003682 | chromatin binding(GO:0003682) |
| 2.2 | 15.2 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 1.0 | 11.2 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 7.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 6.6 | GO:0005518 | collagen binding(GO:0005518) |
| 1.3 | 6.4 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.4 | 6.4 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 6.2 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 5.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 4.6 | GO:1990782 | protein tyrosine kinase binding(GO:1990782) |
| 0.4 | 3.9 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.6 | 3.8 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.1 | 3.6 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.2 | 3.5 | GO:0003680 | AT DNA binding(GO:0003680) |
| 1.1 | 3.3 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.1 | 3.3 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.2 | 3.1 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.0 | 3.1 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 3.0 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.3 | 2.8 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 50 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.4 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 13.4 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 6.8 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 5.9 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 4.2 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 3.9 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.1 | 3.8 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 3.7 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 3.7 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.1 | 3.6 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.1 | 3.5 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.1 | 3.5 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 3.5 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.0 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.1 | 2.9 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 2.8 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.1 | 2.7 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.6 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.1 | 2.6 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.1 | 2.4 | PID_EPO_PATHWAY | EPO signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 58 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.8 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 7.1 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.3 | 6.5 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 6.3 | REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.4 | 5.7 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 3.8 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 3.7 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 3.4 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.3 | 3.3 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.1 | 3.3 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 2.8 | REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR2c ligand binding and activation |
| 0.1 | 2.8 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.1 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 2.0 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.0 | 2.0 | REACTOME_G_ALPHA1213_SIGNALLING_EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.0 | 2.0 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 2.0 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 1.9 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.0 | 1.8 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 1.7 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
