Motif ID: Esr1

Z-value: 0.809


Transcription factors associated with Esr1:

Gene SymbolEntrez IDGene Name
Esr1 ENSMUSG00000019768.10 Esr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr1mm10_v2_chr10_+_4710119_47101660.305.5e-02Click!


Activity profile for motif Esr1.

activity profile for motif Esr1


Sorted Z-values histogram for motif Esr1

Sorted Z-values for motif Esr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_22622183 2.802 ENSMUST00000028123.3
 Gad2
glutamic acid decarboxylase 2
chr10_-_77113676 2.630 ENSMUST00000072755.4
ENSMUST00000105409.1
 Col18a1

collagen, type XVIII, alpha 1

chr7_-_30973399 2.419 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr6_+_6863769 2.297 ENSMUST00000031768.6
 Dlx6
distal-less homeobox 6
chr7_-_30973367 2.244 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr2_-_166155272 2.131 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chr7_-_30973464 2.108 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor
chr6_+_66535390 2.002 ENSMUST00000116605.1
 Mad2l1
MAD2 mitotic arrest deficient-like 1
chr11_-_115612491 1.964 ENSMUST00000106507.2
 Mif4gd
MIF4G domain containing
chr5_-_77095225 1.883 ENSMUST00000120827.2
ENSMUST00000113453.2
 Hopx

HOP homeobox

chr2_+_122147680 1.812 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr8_+_94179089 1.781 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr4_+_124986430 1.715 ENSMUST00000030687.7
 Rspo1
R-spondin homolog (Xenopus laevis)
chr6_+_66535418 1.694 ENSMUST00000101343.1
 Mad2l1
MAD2 mitotic arrest deficient-like 1
chr18_+_74442500 1.646 ENSMUST00000074157.6
 Myo5b
myosin VB
chr10_-_120899067 1.614 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr18_+_74442551 1.581 ENSMUST00000121875.1
 Myo5b
myosin VB
chr9_+_123366921 1.557 ENSMUST00000038863.7
 Lars2
leucyl-tRNA synthetase, mitochondrial
chr6_+_91978851 1.549 ENSMUST00000089334.2
 Fgd5
FYVE, RhoGEF and PH domain containing 5
chr2_+_172549581 1.514 ENSMUST00000030391.2
 Tfap2c
transcription factor AP-2, gamma

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 225 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 6.8 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.4 3.7 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.5 3.2 GO:0032439 endosome localization(GO:0032439)
0.2 3.1 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.6 3.0 GO:0006538 glutamate catabolic process(GO:0006538)
0.7 2.8 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.6 2.5 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
0.4 2.5 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.2 2.5 GO:2000254 regulation of male germ cell proliferation(GO:2000254)
0.8 2.3 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.5 2.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.6 1.9 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.4 1.9 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.0 1.9 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.6 1.8 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 1.8 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 1.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 1.7 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
0.0 1.7 GO:0051290 protein heterotetramerization(GO:0051290)
0.4 1.6 GO:0030091 protein repair(GO:0030091)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 6.8 GO:0061689 tricellular tight junction(GO:0061689)
0.1 4.5 GO:0005643 nuclear pore(GO:0005643)
0.1 3.6 GO:0005581 collagen trimer(GO:0005581)
0.5 3.5 GO:0097452 GAIT complex(GO:0097452)
0.5 3.2 GO:0045179 apical cortex(GO:0045179)
0.2 3.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 2.7 GO:0061574 ASAP complex(GO:0061574)
0.2 2.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.5 2.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 2.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.3 GO:0060077 inhibitory synapse(GO:0060077)
0.0 2.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.1 GO:0005871 kinesin complex(GO:0005871)
0.3 1.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 1.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.6 GO:0005814 centriole(GO:0005814)
0.3 1.5 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.2 1.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 1.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.1 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 3.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.9 2.8 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.4 2.8 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 2.8 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 2.3 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 2.2 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 2.2 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.4 2.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.4 2.1 GO:0043199 Ran guanyl-nucleotide exchange factor activity(GO:0005087) sulfate binding(GO:0043199)
0.0 2.1 GO:0003777 microtubule motor activity(GO:0003777)
0.6 1.9 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.5 1.9 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.6 1.8 GO:0009881 photoreceptor activity(GO:0009881)
0.0 1.8 GO:0005507 copper ion binding(GO:0005507)
0.1 1.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.3 1.6 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.2 1.6 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.1 1.6 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.4 1.5 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.4 NABA_COLLAGENS Genes encoding collagen proteins
0.0 3.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.4 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.9 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 1.8 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.3 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.1 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 0.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.7 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.0 0.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.6 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.5 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.5 PID_ATM_PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.2 4.7 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 3.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 3.0 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 2.9 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.0 2.5 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1 2.2 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 1.9 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 1.9 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.9 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS Genes involved in Host Interactions of HIV factors
0.1 1.7 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.6 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.3 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 1.3 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 1.1 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 1.1 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 1.0 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.1 1.0 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters