Motif ID: Esr2

Z-value: 1.701


Transcription factors associated with Esr2:

Gene SymbolEntrez IDGene Name
Esr2 ENSMUSG00000021055.7 Esr2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr2mm10_v2_chr12_-_76177251_761772650.114.8e-01Click!


Activity profile for motif Esr2.

activity profile for motif Esr2


Sorted Z-values histogram for motif Esr2

Sorted Z-values for motif Esr2



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78499087 7.219 ENSMUST00000017488.4
 Vtn
vitronectin
chr18_+_20665250 6.815 ENSMUST00000075312.3
 Ttr
transthyretin
chr2_-_25470031 6.679 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr2_-_25469742 6.164 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr12_+_112620030 4.677 ENSMUST00000180015.1
ENSMUST00000021726.6
 Adssl1

adenylosuccinate synthetase like 1

chr5_-_113015473 4.400 ENSMUST00000065167.4
 Adrbk2
adrenergic receptor kinase, beta 2
chr4_-_136892867 4.251 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr5_+_35056813 4.206 ENSMUST00000101298.2
ENSMUST00000114270.1
ENSMUST00000133381.1
 Dok7


docking protein 7


chr6_-_35308110 3.565 ENSMUST00000031868.4
 Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr11_-_6065538 3.530 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr13_+_38345716 3.438 ENSMUST00000171970.1
 Bmp6
bone morphogenetic protein 6
chr11_+_101246960 3.320 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr3_-_80802789 3.262 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr15_+_80287234 3.261 ENSMUST00000160424.1
 Cacna1i
calcium channel, voltage-dependent, alpha 1I subunit
chr2_-_131042682 3.235 ENSMUST00000028787.5
ENSMUST00000110239.1
ENSMUST00000110234.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chr7_-_79386943 3.178 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr7_-_126625676 3.145 ENSMUST00000032961.3
 Nupr1
nuclear protein transcription regulator 1
chr9_-_58158498 3.140 ENSMUST00000168864.2
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr9_-_44799179 3.082 ENSMUST00000114705.1
ENSMUST00000002100.7
 Tmem25

transmembrane protein 25

chr9_-_58313189 3.036 ENSMUST00000061799.8
 Loxl1
lysyl oxidase-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 787 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 12.4 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.2 8.4 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
1.0 8.3 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
1.3 6.5 GO:0070327 thyroid hormone transport(GO:0070327)
0.6 6.1 GO:0097421 liver regeneration(GO:0097421)
2.0 6.0 GO:0060466 activation of meiosis involved in egg activation(GO:0060466)
0.5 5.6 GO:0043589 skin morphogenesis(GO:0043589)
0.3 5.5 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.9 5.3 GO:1903275 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.1 5.3 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.7 5.2 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.2 4.9 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
1.2 4.8 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.8 4.8 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.3 4.7 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
1.5 4.6 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
1.5 4.5 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.7 4.5 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.6 4.5 GO:0001955 blood vessel maturation(GO:0001955)
0.2 4.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 274 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 36.0 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 17.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 16.5 GO:0005773 vacuole(GO:0005773)
0.1 8.8 GO:0031594 neuromuscular junction(GO:0031594)
0.1 8.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 8.0 GO:0030673 axolemma(GO:0030673)
1.5 7.6 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.9 7.4 GO:0097433 dense body(GO:0097433)
0.1 7.4 GO:0072562 blood microparticle(GO:0072562)
0.1 6.6 GO:0034704 calcium channel complex(GO:0034704)
0.2 6.1 GO:0031231 intrinsic component of peroxisomal membrane(GO:0031231)
0.2 6.1 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.2 5.4 GO:0051233 spindle midzone(GO:0051233)
1.8 5.3 GO:0005584 collagen type I trimer(GO:0005584)
0.3 5.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 5.2 GO:0097440 apical dendrite(GO:0097440)
0.3 4.9 GO:0005614 interstitial matrix(GO:0005614)
0.2 4.9 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 4.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
1.5 4.6 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 462 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 12.8 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.2 9.4 GO:0005158 insulin receptor binding(GO:0005158)
0.6 8.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
1.1 7.4 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.4 7.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.7 6.3 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 5.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.4 5.6 GO:0046977 TAP binding(GO:0046977)
0.1 5.5 GO:0005518 collagen binding(GO:0005518)
1.7 5.2 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 5.1 GO:0019905 syntaxin binding(GO:0019905)
0.1 5.0 GO:0005178 integrin binding(GO:0005178)
1.6 4.9 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
1.6 4.8 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.2 4.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 4.7 GO:0043274 phospholipase binding(GO:0043274)
1.5 4.6 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
1.2 4.6 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.6 4.5 GO:0015651 quaternary ammonium group transmembrane transporter activity(GO:0015651)
0.1 4.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 22.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 14.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 8.0 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.2 7.6 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.4 7.3 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 7.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.2 5.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 5.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 4.1 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.2 3.9 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 3.7 PID_LKB1_PATHWAY LKB1 signaling events
0.1 3.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.4 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 3.3 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.2 3.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.2 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 3.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 3.0 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 2.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.2 2.7 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 9.7 REACTOME_AMYLOIDS Genes involved in Amyloids
0.5 6.5 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 6.5 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.3 6.4 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.3 6.2 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.3 6.0 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
1.0 5.7 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.4 5.3 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 5.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 5.0 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.2 4.9 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.7 4.4 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.6 4.0 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.2 4.0 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.6 3.9 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.1 3.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 3.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 3.7 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.3 3.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)