Motif ID: Esrrb_Esrra

Z-value: 1.217

Transcription factors associated with Esrrb_Esrra:

Gene SymbolEntrez IDGene Name
Esrra ENSMUSG00000024955.7 Esrra
Esrrb ENSMUSG00000021255.11 Esrrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esrramm10_v2_chr19_-_6921753_6921803-0.124.7e-01Click!
Esrrbmm10_v2_chr12_+_86470109_86470122-0.096.0e-01Click!


Activity profile for motif Esrrb_Esrra.

activity profile for motif Esrrb_Esrra


Sorted Z-values histogram for motif Esrrb_Esrra

Sorted Z-values for motif Esrrb_Esrra



Network of associatons between targets according to the STRING database.



First level regulatory network of Esrrb_Esrra

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_61523889 10.073 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr1_-_84696182 6.224 ENSMUST00000049126.6
 Dner
delta/notch-like EGF-related receptor
chr10_+_128083273 5.749 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr7_-_81706905 5.550 ENSMUST00000026922.7
 Homer2
homer homolog 2 (Drosophila)
chrX_-_72656135 5.299 ENSMUST00000055966.6
 Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr17_+_43952999 5.240 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr11_+_7063423 4.835 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chrX_-_141874870 4.619 ENSMUST00000182079.1
 Gm15294
predicted gene 15294
chr7_-_74554474 4.558 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
 Slco3a1


solute carrier organic anion transporter family, member 3a1


chr7_-_141429351 4.454 ENSMUST00000164387.1
ENSMUST00000137488.1
ENSMUST00000084436.3
 Cend1


cell cycle exit and neuronal differentiation 1


chr15_-_79804717 4.267 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chr4_+_13751297 4.260 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_+_72824482 4.188 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr7_-_141429433 4.146 ENSMUST00000124444.1
 Cend1
cell cycle exit and neuronal differentiation 1
chr7_-_98145472 4.102 ENSMUST00000098281.2
 Omp
olfactory marker protein
chr2_+_121357714 4.050 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
 Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr15_+_84669565 3.913 ENSMUST00000171460.1
 Prr5
proline rich 5 (renal)
chr2_+_121295437 3.886 ENSMUST00000110639.1
 Map1a
microtubule-associated protein 1 A
chr12_-_111672290 3.783 ENSMUST00000001304.7
 Ckb
creatine kinase, brain
chr10_+_110920170 3.764 ENSMUST00000020403.5
 Csrp2
cysteine and glycine-rich protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 253 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 13.7 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.4 9.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
2.9 8.6 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.6 7.7 GO:0015732 prostaglandin transport(GO:0015732)
0.3 7.5 GO:0007614 short-term memory(GO:0007614)
0.7 7.3 GO:0002536 respiratory burst involved in inflammatory response(GO:0002536) negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.7 7.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.3 7.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
1.2 7.0 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.4 6.7 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.4 6.2 GO:0007220 Notch receptor processing(GO:0007220)
0.1 6.1 GO:0032091 negative regulation of protein binding(GO:0032091)
1.4 5.7 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
1.7 5.0 GO:0086047 membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
1.0 4.9 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.3 4.8 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 4.6 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.3 4.2 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.3 4.1 GO:0030238 male sex determination(GO:0030238)
0.2 4.0 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.8 GO:0043209 myelin sheath(GO:0043209)
0.3 14.0 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 14.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.8 13.1 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
1.0 10.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
1.1 9.0 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 7.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.7 7.2 GO:0032426 stereocilium tip(GO:0032426)
0.5 6.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 6.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 6.6 GO:0009925 basal plasma membrane(GO:0009925)
0.1 5.4 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 5.3 GO:0043679 axon terminus(GO:0043679)
0.0 5.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.4 5.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 5.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 4.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 4.4 GO:0016363 nuclear matrix(GO:0016363)
0.3 3.9 GO:0031932 TORC2 complex(GO:0031932)
0.1 3.9 GO:0000786 nucleosome(GO:0000786)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 173 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 11.2 GO:0004111 creatine kinase activity(GO:0004111)
0.5 10.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.6 9.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.9 9.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.4 8.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.3 8.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 8.4 GO:0003735 structural constituent of ribosome(GO:0003735)
1.6 7.8 GO:0043532 angiostatin binding(GO:0043532)
0.3 7.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
1.0 7.3 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.4 6.9 GO:0004890 GABA-A receptor activity(GO:0004890)
0.8 6.6 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.4 5.5 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.9 5.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.7 5.0 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
1.0 4.9 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.8 4.8 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
1.1 4.3 GO:0001847 opsonin receptor activity(GO:0001847)
0.2 4.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 4.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 5.8 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 5.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 5.7 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.3 4.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.3 3.6 PID_ALK2_PATHWAY ALK2 signaling events
0.1 3.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 2.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.4 PID_FGF_PATHWAY FGF signaling pathway
0.0 2.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.0 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 1.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 1.8 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.8 PID_PLK1_PATHWAY PLK1 signaling events
0.1 1.7 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.6 PID_FOXO_PATHWAY FoxO family signaling
0.1 1.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.4 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.3 PID_AURORA_A_PATHWAY Aurora A signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 30.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.8 13.7 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 10.0 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.2 9.7 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.2 9.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.9 7.3 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.2 6.2 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.4 5.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.4 4.8 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 4.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 4.4 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.2 4.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.5 3.6 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 3.4 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 3.2 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 3.1 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.1 2.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 2.9 REACTOME_GPCR_LIGAND_BINDING Genes involved in GPCR ligand binding
0.0 2.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway