Motif ID: Ets1

Z-value: 0.904


Transcription factors associated with Ets1:

Gene SymbolEntrez IDGene Name
Ets1 ENSMUSG00000032035.9 Ets1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ets1mm10_v2_chr9_+_32696005_32696121-0.444.5e-03Click!


Activity profile for motif Ets1.

activity profile for motif Ets1


Sorted Z-values histogram for motif Ets1

Sorted Z-values for motif Ets1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ets1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 6.262 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr11_-_20112876 3.682 ENSMUST00000000137.7
 Actr2
ARP2 actin-related protein 2
chr4_-_63403330 3.430 ENSMUST00000035724.4
 Akna
AT-hook transcription factor
chr6_-_115994953 3.119 ENSMUST00000015511.8
 Plxnd1
plexin D1
chr7_+_62348277 2.816 ENSMUST00000038775.4
 Ndn
necdin
chr9_+_110476985 2.707 ENSMUST00000084948.4
ENSMUST00000061155.6
ENSMUST00000140686.1
ENSMUST00000084952.5
 Kif9



kinesin family member 9



chr12_+_112760652 2.689 ENSMUST00000063888.3
 Pld4
phospholipase D family, member 4
chr10_-_6980376 2.579 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr11_-_76509419 2.500 ENSMUST00000094012.4
 Abr
active BCR-related gene
chr17_+_29090969 2.391 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr14_-_19977249 2.266 ENSMUST00000160013.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr11_+_87592145 2.260 ENSMUST00000103179.3
ENSMUST00000092802.5
ENSMUST00000146871.1
 Mtmr4


myotubularin related protein 4


chr7_-_127218390 2.242 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr3_-_33083016 2.221 ENSMUST00000078226.3
ENSMUST00000108224.1
 Pex5l

peroxisomal biogenesis factor 5-like

chr2_-_12419456 2.186 ENSMUST00000154899.1
ENSMUST00000028105.6
 Fam188a

family with sequence similarity 188, member A

chr9_-_66514567 2.173 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr7_-_127218303 2.142 ENSMUST00000106313.1
 Sept1
septin 1
chr14_-_19977040 2.091 ENSMUST00000159028.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr9_-_57836706 2.051 ENSMUST00000164010.1
ENSMUST00000171444.1
ENSMUST00000098686.3
 Arid3b


AT rich interactive domain 3B (BRIGHT-like)


chr11_-_105944412 2.015 ENSMUST00000019734.4
ENSMUST00000184269.1
ENSMUST00000150563.1
 Cyb561


cytochrome b-561



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 420 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 4.4 GO:0051311 meiotic metaphase plate congression(GO:0051311)
0.1 4.4 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
1.2 3.7 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.2 3.7 GO:0007413 axonal fasciculation(GO:0007413)
0.1 3.6 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.8 3.4 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
1.1 3.3 GO:0021649 vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)
0.2 3.3 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.2 3.2 GO:0015693 magnesium ion transport(GO:0015693)
0.1 3.2 GO:0048268 clathrin coat assembly(GO:0048268)
0.5 3.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 3.1 GO:0071801 regulation of podosome assembly(GO:0071801)
0.1 3.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.2 3.0 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.1 2.9 GO:0045116 protein neddylation(GO:0045116)
0.6 2.8 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1 2.7 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 2.6 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.0 2.6 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.5 2.5 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 225 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 5.9 GO:0043025 neuronal cell body(GO:0043025)
0.1 5.7 GO:0002102 podosome(GO:0002102)
0.3 4.5 GO:0030008 TRAPP complex(GO:0030008)
0.5 4.4 GO:0072687 meiotic spindle(GO:0072687)
0.0 4.4 GO:0030018 Z disc(GO:0030018)
0.1 4.0 GO:0045335 phagocytic vesicle(GO:0045335)
1.0 3.9 GO:1990769 proximal neuron projection(GO:1990769)
0.4 3.7 GO:0030478 actin cap(GO:0030478)
0.2 3.7 GO:0000145 exocyst(GO:0000145)
0.1 3.4 GO:0000242 pericentriolar material(GO:0000242)
0.1 3.2 GO:0070069 cytochrome complex(GO:0070069)
0.5 3.0 GO:0097443 sorting endosome(GO:0097443)
0.0 2.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.5 2.6 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.2 2.6 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 2.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.8 2.4 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 2.4 GO:0044295 axonal growth cone(GO:0044295)
0.8 2.3 GO:0031372 UBC13-MMS2 complex(GO:0031372)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 282 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.2 GO:0008017 microtubule binding(GO:0008017)
0.4 6.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 5.6 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 4.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 4.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 4.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 4.2 GO:0019003 GDP binding(GO:0019003)
0.1 4.0 GO:0050699 WW domain binding(GO:0050699)
0.0 3.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 3.7 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 3.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 3.6 GO:0008565 protein transporter activity(GO:0008565)
0.5 3.5 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 3.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 3.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 3.2 GO:0042169 SH2 domain binding(GO:0042169)
0.1 3.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 3.0 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 2.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.3 2.7 GO:0051434 BH3 domain binding(GO:0051434)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.4 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 8.3 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.5 6.4 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 4.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 4.5 PID_ARF6_PATHWAY Arf6 signaling events
0.1 4.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 3.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.3 3.5 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 3.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 3.1 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 3.1 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 2.9 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 2.5 PID_ARF_3PATHWAY Arf1 pathway
0.0 2.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 2.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 2.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.9 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.8 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 1.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.6 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.5 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.2 6.9 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.2 5.6 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 4.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 4.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 4.2 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.2 4.1 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.3 3.5 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 3.1 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 3.1 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 3.0 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 2.7 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.7 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 2.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 2.6 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 2.4 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 2.3 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.2 1.9 REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE Genes involved in p53-Dependent G1 DNA Damage Response
0.9 1.8 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS Genes involved in Host Interactions of HIV factors
0.3 1.6 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport