Motif ID: Ets2

Z-value: 1.052


Transcription factors associated with Ets2:

Gene SymbolEntrez IDGene Name
Ets2 ENSMUSG00000022895.8 Ets2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ets2mm10_v2_chr16_+_95702044_957020940.711.7e-07Click!


Activity profile for motif Ets2.

activity profile for motif Ets2


Sorted Z-values histogram for motif Ets2

Sorted Z-values for motif Ets2



Network of associatons between targets according to the STRING database.



First level regulatory network of Ets2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5725639 7.472 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr6_+_5725812 5.993 ENSMUST00000115554.1
ENSMUST00000153942.1
 Dync1i1

dynein cytoplasmic 1 intermediate chain 1

chr17_+_3397189 5.296 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr1_-_56969864 5.243 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969827 4.955 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr4_+_128058962 4.404 ENSMUST00000184063.1
 Csmd2
CUB and Sushi multiple domains 2
chr5_+_111733924 4.270 ENSMUST00000180627.1
 Gm26897
predicted gene, 26897
chr10_-_53379816 4.174 ENSMUST00000095691.5
 Cep85l
centrosomal protein 85-like
chr3_-_80802789 4.150 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr15_-_66969616 3.811 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr15_-_43869993 3.765 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr13_-_59823072 3.609 ENSMUST00000071703.4
 Zcchc6
zinc finger, CCHC domain containing 6
chr9_-_29411736 3.573 ENSMUST00000115236.1
 Ntm
neurotrimin
chr1_-_135688094 3.425 ENSMUST00000112103.1
 Nav1
neuron navigator 1
chr12_+_83688123 3.215 ENSMUST00000041806.5
 Psen1
presenilin 1
chr6_-_122340200 3.146 ENSMUST00000159384.1
 Phc1
polyhomeotic-like 1 (Drosophila)
chr11_+_83302817 2.890 ENSMUST00000142680.1
 Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr13_+_109632760 2.832 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr12_-_64965496 2.828 ENSMUST00000021331.7
 Klhl28
kelch-like 28
chr4_-_145194999 2.722 ENSMUST00000036579.7
 Vps13d
vacuolar protein sorting 13 D (yeast)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 197 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.7 GO:0007266 Rho protein signal transduction(GO:0007266)
1.2 13.5 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.6 10.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.7 6.2 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.6 5.6 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.4 5.5 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.3 4.1 GO:0036296 cellular response to increased oxygen levels(GO:0036295) response to increased oxygen levels(GO:0036296)
1.3 3.9 GO:0019085 early viral transcription(GO:0019085)
0.1 3.9 GO:0060612 adipose tissue development(GO:0060612)
0.3 3.8 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.1 3.8 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 3.7 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 3.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.2 3.3 GO:0090161 Golgi ribbon formation(GO:0090161)
0.6 3.2 GO:0015871 astrocyte activation involved in immune response(GO:0002265) choline transport(GO:0015871)
0.5 3.2 GO:0070447 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.3 3.2 GO:0048149 behavioral response to ethanol(GO:0048149)
0.2 3.2 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.2 3.0 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.9 2.8 GO:0043323 positive regulation of natural killer cell degranulation(GO:0043323)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 13.5 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.2 11.9 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.1 11.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 9.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 6.2 GO:0031430 M band(GO:0031430)
0.0 5.6 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.7 5.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 5.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 4.3 GO:0032279 asymmetric synapse(GO:0032279)
0.5 4.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4 3.8 GO:0001739 sex chromatin(GO:0001739)
0.1 3.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.4 3.7 GO:0071439 clathrin complex(GO:0071439)
0.3 3.6 GO:0032584 growth cone membrane(GO:0032584)
0.0 3.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.5 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.4 3.4 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 3.4 GO:0043194 axon initial segment(GO:0043194)
0.1 2.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.9 2.6 GO:0005899 insulin receptor complex(GO:0005899)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 13.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 13.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 10.8 GO:0008565 protein transporter activity(GO:0008565)
0.1 10.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 10.2 GO:0030276 clathrin binding(GO:0030276)
0.1 7.2 GO:0001012 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.1 6.2 GO:0030507 spectrin binding(GO:0030507)
0.0 5.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 4.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 4.2 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.7 4.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 3.9 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.7 3.7 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 3.5 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2 3.4 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 3.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.4 3.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 2.9 GO:0005158 insulin receptor binding(GO:0005158)
0.1 2.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 2.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 5.4 PID_INSULIN_PATHWAY Insulin Pathway
0.1 4.7 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 4.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 4.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.2 3.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 3.1 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 2.8 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.7 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 2.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 2.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 1.8 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.6 PID_BCR_5PATHWAY BCR signaling pathway
0.1 1.5 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 1.4 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.4 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 1.3 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.3 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.8 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.4 10.3 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 8.2 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.4 6.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.3 4.2 REACTOME_SIGNALING_BY_NOTCH4 Genes involved in Signaling by NOTCH4
0.2 4.2 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.2 3.9 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 2.9 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 2.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 2.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.6 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.2 2.5 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 2.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.0 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 1.9 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 1.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 1.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 1.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.5 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.5 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters