Motif ID: Etv3_Erf_Fev_Elk4_Elk1_Elk3

Z-value: 0.913

Transcription factors associated with Etv3_Erf_Fev_Elk4_Elk1_Elk3:

Gene SymbolEntrez IDGene Name
Elk1 ENSMUSG00000009406.7 Elk1
Elk3 ENSMUSG00000008398.8 Elk3
Elk4 ENSMUSG00000026436.9 Elk4
Erf ENSMUSG00000040857.9 Erf
Etv3 ENSMUSG00000003382.12 Etv3
Fev ENSMUSG00000055197.4 Fev

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elk1mm10_v2_chrX_-_20950597_209506130.751.8e-08Click!
Elk4mm10_v2_chr1_+_132007606_1320076340.695.9e-07Click!
Etv3mm10_v2_chr3_+_87525572_875256430.612.7e-05Click!
Erfmm10_v2_chr7_-_25250720_25250761-0.434.8e-03Click!
Elk3mm10_v2_chr10_-_93311073_93311161-0.134.3e-01Click!


Activity profile for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3.

activity profile for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3


Sorted Z-values histogram for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3

Sorted Z-values for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv3_Erf_Fev_Elk4_Elk1_Elk3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_163602331 10.514 ENSMUST00000152135.1
 Ttpal
tocopherol (alpha) transfer protein-like
chr11_+_54522872 7.041 ENSMUST00000108895.1
ENSMUST00000101206.3
 Rapgef6

Rap guanine nucleotide exchange factor (GEF) 6

chr12_+_80644212 5.899 ENSMUST00000085245.5
 Slc39a9
solute carrier family 39 (zinc transporter), member 9
chr12_-_84970814 5.444 ENSMUST00000165886.1
ENSMUST00000167448.1
ENSMUST00000043169.7
 Arel1


apoptosis resistant E3 ubiquitin protein ligase 1


chr8_-_69791170 5.443 ENSMUST00000131784.1
 Zfp866
zinc finger protein 866
chr1_-_133025330 5.436 ENSMUST00000067429.3
ENSMUST00000067398.6
 Mdm4

transformed mouse 3T3 cell double minute 4

chr6_+_86849488 5.387 ENSMUST00000089519.6
ENSMUST00000113668.1
 Aak1

AP2 associated kinase 1

chr12_-_64965496 5.252 ENSMUST00000021331.7
 Klhl28
kelch-like 28
chr9_-_44965519 4.996 ENSMUST00000125642.1
ENSMUST00000117506.1
ENSMUST00000117549.1
 Ube4a


ubiquitination factor E4A, UFD2 homolog (S. cerevisiae)


chr7_+_127876796 4.856 ENSMUST00000131000.1
 Zfp646
zinc finger protein 646
chr1_+_118389058 4.815 ENSMUST00000049404.6
ENSMUST00000070989.7
ENSMUST00000165223.1
ENSMUST00000178710.1
 Clasp1



CLIP associating protein 1



chr17_+_33955902 4.783 ENSMUST00000173196.2
 Vps52
vacuolar protein sorting 52 (yeast)
chrX_-_12762069 4.668 ENSMUST00000096495.4
ENSMUST00000076016.5
 Med14

mediator complex subunit 14

chr18_-_84589491 4.610 ENSMUST00000125763.1
 Zfp407
zinc finger protein 407
chr11_+_83299005 4.597 ENSMUST00000176944.1
 Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr16_-_87432597 4.542 ENSMUST00000039449.7
 Ltn1
listerin E3 ubiquitin protein ligase 1
chr5_-_3803081 4.507 ENSMUST00000043551.6
 Ankib1
ankyrin repeat and IBR domain containing 1
chr7_+_122067164 4.413 ENSMUST00000033158.4
 Ubfd1
ubiquitin family domain containing 1
chr9_+_65908967 4.394 ENSMUST00000034949.3
ENSMUST00000154589.1
 Csnk1g1

casein kinase 1, gamma 1

chr17_+_35135463 4.277 ENSMUST00000173535.1
ENSMUST00000173952.1
 Bag6

BCL2-associated athanogene 6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 444 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 13.2 GO:0060363 cranial suture morphogenesis(GO:0060363)
1.4 12.2 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.5 10.7 GO:0030033 microvillus assembly(GO:0030033)
0.1 9.9 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
1.2 9.3 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.3 9.3 GO:0006829 zinc II ion transport(GO:0006829)
2.8 8.5 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.2 8.3 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.5 6.8 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.3 6.8 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
1.6 6.4 GO:0055071 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
1.9 5.8 GO:0019085 early viral transcription(GO:0019085)
1.2 5.8 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1 5.7 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.4 5.5 GO:0030157 pancreatic juice secretion(GO:0030157)
0.4 5.4 GO:0003283 atrial septum development(GO:0003283)
0.2 5.3 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.2 5.1 GO:0002076 osteoblast development(GO:0002076)
1.0 5.0 GO:0021764 amygdala development(GO:0021764)
0.1 5.0 GO:0030521 androgen receptor signaling pathway(GO:0030521)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 186 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 22.4 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
1.6 13.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.3 10.8 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 10.7 GO:0005768 endosome(GO:0005768)
0.1 10.5 GO:0005802 trans-Golgi network(GO:0005802)
2.1 10.4 GO:1990745 EARP complex(GO:1990745)
0.1 9.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
1.3 9.3 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 9.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.4 7.8 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 7.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.7 7.0 GO:0071439 clathrin complex(GO:0071439)
0.1 7.0 GO:0005769 early endosome(GO:0005769)
0.7 6.7 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4 5.6 GO:0017119 Golgi transport complex(GO:0017119)
0.9 5.5 GO:0097443 sorting endosome(GO:0097443)
0.1 5.5 GO:0030139 endocytic vesicle(GO:0030139)
0.1 5.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
1.3 5.3 GO:1990769 proximal neuron projection(GO:1990769)
0.0 5.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 266 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 29.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 28.2 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 23.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 21.2 GO:0008270 zinc ion binding(GO:0008270)
0.2 14.3 GO:0030276 clathrin binding(GO:0030276)
0.3 13.7 GO:0070063 RNA polymerase binding(GO:0070063)
0.6 12.6 GO:0070300 phosphatidic acid binding(GO:0070300)
0.7 8.7 GO:0015643 toxic substance binding(GO:0015643)
0.4 8.3 GO:0008179 adenylate cyclase binding(GO:0008179)
0.3 6.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
1.6 6.4 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.3 5.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 5.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 5.9 GO:0051018 protein kinase A binding(GO:0051018)
0.1 5.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 5.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 5.2 GO:0046873 metal ion transmembrane transporter activity(GO:0046873)
0.3 4.9 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
1.6 4.8 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
1.0 4.8 GO:0043515 kinetochore binding(GO:0043515)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.9 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.3 7.6 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 6.0 SIG_CHEMOTAXIS Genes related to chemotaxis
0.1 5.8 PID_INSULIN_PATHWAY Insulin Pathway
0.2 5.1 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.2 4.9 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 4.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 4.3 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 4.1 PID_ARF_3PATHWAY Arf1 pathway
0.1 3.7 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 3.6 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.2 3.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 2.7 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 2.6 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 2.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.3 2.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.2 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.1 PID_EPHB_FWD_PATHWAY EPHB forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.1 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.3 10.7 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.7 10.2 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.4 8.7 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.7 8.5 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.6 8.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 7.7 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.0 6.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 6.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.3 4.9 REACTOME_PHOSPHORYLATION_OF_THE_APC_C Genes involved in Phosphorylation of the APC/C
0.4 4.6 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.2 4.4 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 3.7 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.2 3.6 REACTOME_SIGNALING_BY_NOTCH4 Genes involved in Signaling by NOTCH4
0.1 3.5 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 3.4 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.3 3.3 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 3.2 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.2 3.1 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3 3.0 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1