Motif ID: Etv4

Z-value: 0.467


Transcription factors associated with Etv4:

Gene SymbolEntrez IDGene Name
Etv4 ENSMUSG00000017724.8 Etv4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Etv4mm10_v2_chr11_-_101785252_101785371-0.105.3e-01Click!


Activity profile for motif Etv4.

activity profile for motif Etv4


Sorted Z-values histogram for motif Etv4

Sorted Z-values for motif Etv4



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_56133817 1.729 ENSMUST00000167545.1
Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr6_+_5725639 1.305 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr15_-_66812593 1.260 ENSMUST00000100572.3
Sla
src-like adaptor
chr7_-_27181149 1.234 ENSMUST00000071986.6
ENSMUST00000121848.1
Mia

melanoma inhibitory activity

chr6_+_115134899 1.216 ENSMUST00000009538.5
ENSMUST00000169345.1
Syn2

synapsin II

chr15_-_66969616 1.178 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
Ndrg1



N-myc downstream regulated gene 1



chr3_+_123267445 1.170 ENSMUST00000047923.7
Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr13_+_109632760 1.094 ENSMUST00000135275.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr17_+_3397189 0.996 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr9_+_107935876 0.945 ENSMUST00000035700.8
Camkv
CaM kinase-like vesicle-associated
chr7_+_45627482 0.938 ENSMUST00000057927.7
Rasip1
Ras interacting protein 1
chr12_-_84970814 0.938 ENSMUST00000165886.1
ENSMUST00000167448.1
ENSMUST00000043169.7
Arel1


apoptosis resistant E3 ubiquitin protein ligase 1


chr6_+_8259288 0.903 ENSMUST00000159335.1
Gm16039
predicted gene 16039
chr9_-_40346290 0.866 ENSMUST00000121357.1
Gramd1b
GRAM domain containing 1B
chr3_-_87768932 0.821 ENSMUST00000173184.1
ENSMUST00000172621.1
ENSMUST00000174759.1
ENSMUST00000172590.1
ENSMUST00000079083.5
Pear1




platelet endothelial aggregation receptor 1




chr7_+_49246131 0.816 ENSMUST00000064395.6
Nav2
neuron navigator 2
chr1_-_56969864 0.801 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr2_-_92024502 0.796 ENSMUST00000028663.4
Creb3l1
cAMP responsive element binding protein 3-like 1
chrX_+_159840463 0.783 ENSMUST00000112451.1
ENSMUST00000112453.2
Sh3kbp1

SH3-domain kinase binding protein 1

chr9_+_108290433 0.731 ENSMUST00000035227.6
Nicn1
nicolin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 218 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0032526 response to retinoic acid(GO:0032526)
0.1 1.7 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 1.6 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.1 1.6 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.2 1.5 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0 1.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 1.3 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.2 1.2 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 1.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.3 1.0 GO:1905065 positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.2 1.0 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.1 1.0 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.1 1.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 1.0 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.2 0.9 GO:0014042 positive regulation of neuron maturation(GO:0014042)
0.2 0.9 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.2 0.9 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0 0.9 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.9 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.9 GO:0010507 negative regulation of autophagy(GO:0010507)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.6 GO:0031225 anchored component of membrane(GO:0031225)
0.2 1.5 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.4 1.3 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.2 1.2 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 1.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 1.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.1 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 0.9 GO:0097443 sorting endosome(GO:0097443)
0.1 0.9 GO:0071439 clathrin complex(GO:0071439)
0.1 0.9 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.9 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 0.8 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.8 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.7 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 0.7 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.7 GO:0030673 axolemma(GO:0030673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 136 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.0 GO:0008083 growth factor activity(GO:0008083)
0.1 1.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.7 GO:0030276 clathrin binding(GO:0030276)
0.1 1.5 GO:0015643 toxic substance binding(GO:0015643)
0.0 1.4 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 1.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 1.3 GO:0035497 cAMP response element binding(GO:0035497)
0.2 1.2 GO:0097643 amylin receptor activity(GO:0097643)
0.0 1.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 1.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.1 GO:0000149 SNARE binding(GO:0000149)
0.0 0.9 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.2 0.8 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441)
0.0 0.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.8 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.2 0.7 GO:0071209 U7 snRNA binding(GO:0071209)
0.1 0.7 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 2.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.3 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 1.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.9 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.9 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.0 0.7 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.6 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.4 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.4 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.4 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.3 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 0.3 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.2 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 1.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.2 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.0 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.0 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.9 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.9 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.8 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 0.7 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.7 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.7 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.7 REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ Genes involved in Formation of RNA Pol II elongation complex
0.0 0.6 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
0.0 0.6 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.5 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport