Motif ID: Etv6

Z-value: 0.772


Transcription factors associated with Etv6:

Gene SymbolEntrez IDGene Name
Etv6 ENSMUSG00000030199.10 Etv6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Etv6mm10_v2_chr6_+_134035953_1340359730.144.0e-01Click!


Activity profile for motif Etv6.

activity profile for motif Etv6


Sorted Z-values histogram for motif Etv6

Sorted Z-values for motif Etv6



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_74601441 0.961 ENSMUST00000087183.4
ENSMUST00000148456.1
ENSMUST00000113694.1
 Stk36


serine/threonine kinase 36


chr10_-_67285180 0.957 ENSMUST00000159002.1
ENSMUST00000077839.6
 Nrbf2

nuclear receptor binding factor 2

chr4_+_155943824 0.899 ENSMUST00000103175.1
ENSMUST00000166489.1
ENSMUST00000024056.3
ENSMUST00000136492.1
ENSMUST00000105583.2
ENSMUST00000152536.1
 Ube2j2





ubiquitin-conjugating enzyme E2J 2





chr12_+_102757965 0.858 ENSMUST00000046404.6
 Ubr7
ubiquitin protein ligase E3 component n-recognin 7 (putative)
chr1_+_74601548 0.846 ENSMUST00000087186.4
 Stk36
serine/threonine kinase 36
chr2_+_168230597 0.841 ENSMUST00000099071.3
 Mocs3
molybdenum cofactor synthesis 3
chr9_+_48450327 0.833 ENSMUST00000165252.1
 Gm5616
predicted gene 5616
chr1_-_183221529 0.828 ENSMUST00000003035.5
 Disp1
dispatched homolog 1 (Drosophila)
chr4_+_118409331 0.824 ENSMUST00000084319.4
ENSMUST00000106384.3
ENSMUST00000126089.1
ENSMUST00000073881.1
ENSMUST00000019229.8
ENSMUST00000144577.1
 Med8





mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)





chr3_-_89764581 0.809 ENSMUST00000029562.3
 Chrnb2
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
chr8_-_72571033 0.809 ENSMUST00000058733.8
ENSMUST00000167290.1
 Smim7

small integral membrane protein 7

chr7_-_105744312 0.796 ENSMUST00000141116.1
 Taf10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr4_-_98383232 0.764 ENSMUST00000143116.1
ENSMUST00000030292.5
ENSMUST00000102793.4
 Tm2d1


TM2 domain containing 1


chr4_-_136886187 0.747 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr10_-_31609184 0.733 ENSMUST00000081989.6
 Rnf217
ring finger protein 217
chr13_+_4191163 0.725 ENSMUST00000021634.2
 Akr1c13
aldo-keto reductase family 1, member C13
chr11_-_35834492 0.724 ENSMUST00000018992.3
 Rars
arginyl-tRNA synthetase
chr5_-_149636164 0.719 ENSMUST00000076410.4
 Hsph1
heat shock 105kDa/110kDa protein 1
chr6_-_120822680 0.693 ENSMUST00000019354.8
 Atp6v1e1
ATPase, H+ transporting, lysosomal V1 subunit E1
chr3_+_95217417 0.683 ENSMUST00000181819.1
 Gm16740
predicted gene, 16740

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 2.4 GO:0006413 translational initiation(GO:0006413)
0.5 1.8 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.1 1.5 GO:0006465 signal peptide processing(GO:0006465)
0.2 1.4 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.3 1.2 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) positive regulation of NK T cell activation(GO:0051135)
0.1 1.2 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.2 1.1 GO:0035878 nail development(GO:0035878)
0.2 1.1 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.2 1.0 GO:0090005 negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.1 1.0 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 1.0 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.0 1.0 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.1 0.9 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.3 0.8 GO:0060084 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) synaptic transmission involved in micturition(GO:0060084)
0.2 0.8 GO:0018307 tRNA wobble position uridine thiolation(GO:0002143) enzyme active site formation(GO:0018307)
0.1 0.8 GO:0060539 diaphragm development(GO:0060539)
0.1 0.8 GO:0070365 hepatocyte differentiation(GO:0070365)
0.0 0.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.8 GO:0032543 mitochondrial translation(GO:0032543)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.6 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 1.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2 1.5 GO:0005787 signal peptidase complex(GO:0005787)
0.2 1.4 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 1.3 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 1.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 1.2 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.4 1.1 GO:1903095 microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095)
0.1 1.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 1.0 GO:0005839 proteasome core complex(GO:0005839)
0.0 1.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.2 0.9 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.2 0.9 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.3 0.8 GO:0099631 postsynaptic endocytic zone cytoplasmic component(GO:0099631)
0.1 0.8 GO:0000125 PCAF complex(GO:0000125)
0.1 0.8 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.8 GO:0005689 U12-type spliceosomal complex(GO:0005689)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 2.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 1.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 1.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.6 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 1.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 1.4 GO:0015643 toxic substance binding(GO:0015643)
0.0 1.3 GO:0043022 ribosome binding(GO:0043022)
0.3 1.2 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 1.2 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769)
0.2 1.1 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1 1.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 1.0 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 1.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.9 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.2 0.8 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.1 0.8 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.8 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.8 GO:0015197 peptide transporter activity(GO:0015197)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.6 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.5 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.2 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 1.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.9 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.8 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.7 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.6 PID_MYC_PATHWAY C-MYC pathway
0.0 0.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.5 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.5 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.5 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.3 PID_AP1_PATHWAY AP-1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.5 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.1 2.2 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 1.7 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 1.6 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.1 1.5 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 1.2 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 1.2 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.2 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.1 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.1 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 1.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.0 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 1.0 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.9 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 0.8 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.8 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.8 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.8 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors