Motif ID: Fli1

Z-value: 1.617


Transcription factors associated with Fli1:

Gene SymbolEntrez IDGene Name
Fli1 ENSMUSG00000016087.7 Fli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fli1mm10_v2_chr9_-_32541589_32541602-0.086.1e-01Click!


Activity profile for motif Fli1.

activity profile for motif Fli1


Sorted Z-values histogram for motif Fli1

Sorted Z-values for motif Fli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Fli1

PNG image of the network

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Top targets:


Showing 1 to 20 of 154 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_175491130 43.723 ENSMUST00000027812.5
 Rgs7
regulator of G protein signaling 7
chr10_+_26229707 40.236 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chrX_-_136868537 21.370 ENSMUST00000058814.6
 Rab9b
RAB9B, member RAS oncogene family
chr7_-_140082489 12.590 ENSMUST00000026541.7
 Caly
calcyon neuron-specific vesicular protein
chr9_+_74848437 9.336 ENSMUST00000161862.1
ENSMUST00000162089.1
ENSMUST00000160017.1
ENSMUST00000160950.1
 Gm16551


Gm20649
predicted gene 16551


predicted gene 20649
chr11_+_32000496 8.548 ENSMUST00000093219.3
 Nsg2
neuron specific gene family member 2
chr4_+_43406435 8.190 ENSMUST00000098106.2
ENSMUST00000139198.1
 Rusc2

RUN and SH3 domain containing 2

chr11_-_100759740 8.090 ENSMUST00000107361.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr11_+_32000452 8.029 ENSMUST00000020537.2
ENSMUST00000109409.1
 Nsg2

neuron specific gene family member 2

chr11_-_100759942 7.621 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr6_-_77979515 7.315 ENSMUST00000159626.1
ENSMUST00000075340.5
ENSMUST00000162273.1
 Ctnna2


catenin (cadherin associated protein), alpha 2


chr11_-_68927049 6.954 ENSMUST00000038932.7
 Odf4
outer dense fiber of sperm tails 4
chr6_-_77979652 6.706 ENSMUST00000161846.1
ENSMUST00000160894.1
 Ctnna2

catenin (cadherin associated protein), alpha 2

chrX_+_123581700 5.868 ENSMUST00000178457.1
 Gm6604
predicted gene 6604
chrX_+_123793665 5.709 ENSMUST00000178148.1
 Gm5167
predicted gene 5167
chr5_+_117133567 5.528 ENSMUST00000179276.1
ENSMUST00000092889.5
ENSMUST00000145640.1
 Taok3


TAO kinase 3


chr16_-_42340595 5.303 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chr8_+_23035116 5.274 ENSMUST00000117296.1
ENSMUST00000141784.2
 Ank1

ankyrin 1, erythroid

chr9_+_118478182 5.148 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr2_+_65845833 4.909 ENSMUST00000053910.3
 Csrnp3
cysteine-serine-rich nuclear protein 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 43.7 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
1.1 29.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.3 21.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
1.2 14.0 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
1.3 13.9 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 12.8 GO:0042391 regulation of membrane potential(GO:0042391)
0.1 9.9 GO:0007631 feeding behavior(GO:0007631)
0.1 9.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 9.0 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.3 5.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.2 5.4 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.6 5.3 GO:0016198 axon choice point recognition(GO:0016198)
0.0 5.3 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 4.8 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.4 4.4 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
1.0 4.0 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.0 4.0 GO:0030516 regulation of axon extension(GO:0030516)
0.1 3.9 GO:2001222 regulation of neuron migration(GO:2001222)
0.1 3.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 3.6 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 43.7 GO:0044292 dendrite terminus(GO:0044292)
0.0 29.3 GO:0031410 cytoplasmic vesicle(GO:0031410)
1.1 22.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.3 21.4 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 13.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 9.6 GO:0031225 anchored component of membrane(GO:0031225)
0.9 7.0 GO:0001520 outer dense fiber(GO:0001520)
0.3 5.3 GO:0031527 filopodium membrane(GO:0031527)
0.8 4.9 GO:0044308 axonal spine(GO:0044308)
0.0 4.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 3.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 3.5 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.1 3.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 2.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 2.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.8 2.3 GO:0034667 integrin alpha3-beta1 complex(GO:0034667)
0.0 1.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.5 GO:0043197 dendritic spine(GO:0043197)
0.0 1.3 GO:0005923 bicellular tight junction(GO:0005923)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 48.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
3.6 29.2 GO:0032051 clathrin light chain binding(GO:0032051)
0.3 21.4 GO:0019003 GDP binding(GO:0019003)
0.2 15.7 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.3 13.9 GO:0030507 spectrin binding(GO:0030507)
1.1 9.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 6.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 6.4 GO:0051015 actin filament binding(GO:0051015)
0.8 5.9 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 5.4 GO:0017137 Rab GTPase binding(GO:0017137)
1.3 4.0 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.2 3.6 GO:0004890 GABA-A receptor activity(GO:0004890)
0.3 3.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 3.3 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 3.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 3.0 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 2.7 GO:0042169 SH2 domain binding(GO:0042169)
0.1 2.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 2.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 2.3 GO:0043236 laminin binding(GO:0043236)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.2 5.2 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 5.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 4.8 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 4.0 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 2.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 2.1 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 1.5 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 1.4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 1.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.0 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.0 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.5 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.5 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.3 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.3 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 43.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.6 22.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 15.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 4.9 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 3.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 3.5 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 3.1 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 3.0 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 2.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 2.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 2.1 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 1.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 1.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.2 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 1.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.0 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.9 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+