Motif ID: Fos

Z-value: 0.914


Transcription factors associated with Fos:

Gene SymbolEntrez IDGene Name
Fos ENSMUSG00000021250.7 Fos

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosmm10_v2_chr12_+_85473883_85473896-0.095.8e-01Click!


Activity profile for motif Fos.

activity profile for motif Fos


Sorted Z-values histogram for motif Fos

Sorted Z-values for motif Fos



Network of associatons between targets according to the STRING database.



First level regulatory network of Fos

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_13573927 11.493 ENSMUST00000141365.1
ENSMUST00000028062.2
 Vim

vimentin

chr2_+_20737306 10.357 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr2_+_30078584 6.553 ENSMUST00000045246.7
 Pkn3
protein kinase N3
chr18_+_82910863 6.259 ENSMUST00000171238.1
 Zfp516
zinc finger protein 516
chr13_+_15463837 6.086 ENSMUST00000110510.3
 Gli3
GLI-Kruppel family member GLI3
chr7_+_19083842 5.937 ENSMUST00000032568.7
ENSMUST00000122999.1
ENSMUST00000108473.3
ENSMUST00000108474.1
 Dmpk



dystrophia myotonica-protein kinase



chr16_-_44558864 5.816 ENSMUST00000023370.4
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr10_-_42583628 5.425 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr16_-_44558879 5.311 ENSMUST00000114634.1
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr9_+_78615501 5.186 ENSMUST00000093812.4
 Cd109
CD109 antigen
chr19_+_36409719 4.762 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr10_+_88091070 4.471 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr7_-_126799163 4.409 ENSMUST00000032934.5
 Aldoa
aldolase A, fructose-bisphosphate
chr1_+_107511489 4.286 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr7_-_126799134 4.255 ENSMUST00000087566.4
 Aldoa
aldolase A, fructose-bisphosphate
chr1_+_107511416 4.196 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr6_+_135362931 4.135 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1
chr2_+_167777467 3.969 ENSMUST00000139927.1
ENSMUST00000127441.1
 Gm14321

predicted gene 14321

chr9_+_69453620 3.824 ENSMUST00000034756.8
ENSMUST00000123470.1
 Anxa2

annexin A2

chr15_-_103366763 3.791 ENSMUST00000023128.6
 Itga5
integrin alpha 5 (fibronectin receptor alpha)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 133 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 11.5 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.4 11.1 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.9 8.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 7.3 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.2 7.0 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 6.3 GO:0048706 embryonic skeletal system development(GO:0048706)
2.0 6.1 GO:0060364 frontal suture morphogenesis(GO:0060364)
1.5 6.0 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
1.0 5.8 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
1.1 5.4 GO:0021764 amygdala development(GO:0021764)
1.0 5.2 GO:0072675 osteoclast fusion(GO:0072675)
0.3 5.2 GO:0032060 bleb assembly(GO:0032060)
1.5 4.5 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.2 4.3 GO:0003334 keratinocyte development(GO:0003334)
0.2 4.1 GO:0043486 histone exchange(GO:0043486)
0.0 3.9 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process(GO:0043161)
0.8 3.8 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.4 3.8 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.2 3.7 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.2 3.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.7 GO:0044295 axonal growth cone(GO:0044295)
2.9 11.5 GO:0045098 type III intermediate filament(GO:0045098)
0.6 8.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 6.0 GO:0032587 ruffle membrane(GO:0032587)
0.1 5.6 GO:0016592 mediator complex(GO:0016592)
0.1 5.4 GO:0034707 chloride channel complex(GO:0034707)
0.3 5.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 5.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 4.8 GO:0031519 PcG protein complex(GO:0031519)
0.0 4.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.4 3.9 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
1.3 3.8 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 3.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 3.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 3.6 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 3.6 GO:0044449 contractile fiber part(GO:0044449)
0.0 3.5 GO:0031225 anchored component of membrane(GO:0031225)
0.2 3.4 GO:0005614 interstitial matrix(GO:0005614)
0.3 3.1 GO:0005915 zonula adherens(GO:0005915)
0.2 3.1 GO:0031932 TORC2 complex(GO:0031932)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 12.1 GO:0019208 phosphatase regulator activity(GO:0019208)
2.8 11.3 GO:1990254 keratin filament binding(GO:1990254)
1.4 8.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 7.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.3 6.6 GO:0004697 protein kinase C activity(GO:0004697)
0.1 6.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 5.4 GO:0042826 histone deacetylase binding(GO:0042826)
0.3 5.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 5.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 4.3 GO:0015459 potassium channel regulator activity(GO:0015459)
1.0 3.8 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.6 3.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.3 3.6 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.7 3.5 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 3.5 GO:0004407 histone deacetylase activity(GO:0004407)
0.2 3.4 GO:0017166 vinculin binding(GO:0017166)
0.1 3.4 GO:0008009 chemokine activity(GO:0008009)
0.0 3.4 GO:0015108 chloride transmembrane transporter activity(GO:0015108)
0.1 3.3 GO:0001786 phosphatidylserine binding(GO:0001786)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 12.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.3 11.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 8.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.2 6.9 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 6.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 4.6 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 3.7 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 3.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.5 PID_ARF_3PATHWAY Arf1 pathway
0.1 2.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 2.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 2.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.6 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.4 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 1.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.1 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.5 11.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 10.6 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2 7.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 4.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.5 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.4 3.0 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 2.9 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.2 2.8 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 2.2 REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 2.0 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 2.0 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 1.8 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.8 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
0.1 1.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 1.4 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 1.4 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 1.3 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.1 1.2 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction