ISMARA results: Fosb

Motif ID: Fosb

Z-value: 0.404

Transcription factors associated with Fosb:

Gene Symbol	Entrez ID	Gene Name
Fosb	ENSMUSG00000003545.2	Fosb

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Fosb	mm10_v2_chr7_-_19310035_19310050	-0.50	9.5e-04	Click!

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Top targets:

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Showing 1 to 20 of 83 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr14_+_80000292	1.831	ENSMUST00000088735.3	Olfm4	olfactomedin 4
chr6_+_17463927	1.606	ENSMUST00000115442.1	Met	met proto-oncogene
chr8_+_107293500	1.145	ENSMUST00000151114.1 ENSMUST00000075922.4 ENSMUST00000125721.1	Nfat5	nuclear factor of activated T cells 5
chr14_+_27622433	1.138	ENSMUST00000090302.5	Erc2	ELKS/RAB6-interacting/CAST family member 2
chr16_+_78930940	1.138	ENSMUST00000114216.1 ENSMUST00000069148.6 ENSMUST00000023568.7	Chodl	chondrolectin
chr6_+_86849488	1.039	ENSMUST00000089519.6 ENSMUST00000113668.1	Aak1	AP2 associated kinase 1
chr6_-_113934679	0.976	ENSMUST00000101044.2	Atp2b2	ATPase, Ca++ transporting, plasma membrane 2
chr2_-_29253001	0.938	ENSMUST00000071201.4	Ntng2	netrin G2
chr3_+_123267445	0.933	ENSMUST00000047923.7	Sec24d	Sec24 related gene family, member D (S. cerevisiae)
chr3_+_55461758	0.846	ENSMUST00000070418.4	Dclk1	doublecortin-like kinase 1
chr2_+_118663235	0.818	ENSMUST00000099557.3	Pak6	p21 protein (Cdc42/Rac)-activated kinase 6
chr8_-_8639363	0.812	ENSMUST00000152698.1	Efnb2	ephrin B2
chr11_-_120630516	0.756	ENSMUST00000106181.1	Mafg	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr2_-_45110241	0.738	ENSMUST00000177302.1	Zeb2	zinc finger E-box binding homeobox 2
chr11_-_84067063	0.666	ENSMUST00000108101.1	Dusp14	dual specificity phosphatase 14
chr1_+_134560190	0.645	ENSMUST00000112198.1 ENSMUST00000112197.1	Kdm5b	lysine (K)-specific demethylase 5B
chr2_-_18048784	0.624	ENSMUST00000142856.1	Skida1	SKI/DACH domain containing 1
chr17_+_35841668	0.616	ENSMUST00000174124.1	Mdc1	mediator of DNA damage checkpoint 1
chr15_-_102257306	0.610	ENSMUST00000135466.1	Rarg	retinoic acid receptor, gamma
chr11_-_100397740	0.590	ENSMUST00000001592.8 ENSMUST00000107403.1	Jup	junction plakoglobin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 34 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.2	1.6	GO:0070494	regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0	1.1	GO:0070884	regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.2	1.0	GO:0035937	estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.2	1.0	GO:0003430	growth plate cartilage chondrocyte growth(GO:0003430)
0.2	1.0	GO:0048840	otolith development(GO:0048840)
0.0	1.0	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
0.1	0.9	GO:0090343	positive regulation of cell aging(GO:0090343)
0.1	0.9	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.1	0.9	GO:1902004	positive regulation of beta-amyloid formation(GO:1902004)
0.1	0.8	GO:1903847	regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0	0.8	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
0.1	0.7	GO:1903056	positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0	0.7	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.2	0.6	GO:0002159	desmosome assembly(GO:0002159)
0.0	0.6	GO:0072583	clathrin-mediated endocytosis(GO:0072583)
0.1	0.5	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.5	GO:0033198	response to ATP(GO:0033198)
0.0	0.5	GO:0060325	face morphogenesis(GO:0060325)
0.1	0.4	GO:0034773	histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)

Gene overrepresentation in cellular_component category:

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Showing 1 to 18 of 18 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.2	GO:0042734	presynaptic membrane(GO:0042734)
0.1	1.8	GO:0042581	specific granule(GO:0042581)
0.0	1.6	GO:0009925	basal plasma membrane(GO:0009925)
0.1	1.0	GO:0071439	clathrin complex(GO:0071439)
0.0	1.0	GO:0098839	postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1	0.9	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.9	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.1	0.6	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1	0.6	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.5	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1	0.4	GO:0044753	amphisome(GO:0044753)
0.1	0.4	GO:0061689	tricellular tight junction(GO:0061689)
0.1	0.4	GO:0005638	lamin filament(GO:0005638)
0.1	0.3	GO:0012510	trans-Golgi network transport vesicle membrane(GO:0012510)
0.0	0.3	GO:0045095	keratin filament(GO:0045095)
0.1	0.2	GO:0097447	dendritic tree(GO:0097447)
0.0	0.2	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.2	GO:0000138	Golgi trans cisterna(GO:0000138)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 28 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.6	GO:0005008	hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2	1.0	GO:0034647	histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.1	1.0	GO:0035612	AP-2 adaptor complex binding(GO:0035612)
0.1	1.0	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	1.0	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.8	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.8	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	0.7	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.7	GO:0070412	R-SMAD binding(GO:0070412)
0.0	0.7	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1	0.6	GO:0032050	clathrin heavy chain binding(GO:0032050)
0.0	0.6	GO:0045294	alpha-catenin binding(GO:0045294)
0.1	0.5	GO:0035381	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1	0.4	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.4	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.4	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.0	0.4	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.1	0.3	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.1	0.3	GO:1990254	keratin filament binding(GO:1990254)
0.0	0.3	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)

Gene overrepresentation in C2:CP category:

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Showing 1 to 11 of 11 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.2	PID_ARF6_PATHWAY	Arf6 signaling events
0.0	1.1	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	1.0	PID_RXR_VDR_PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.9	NABA_BASEMENT_MEMBRANES	Genes encoding structural components of basement membranes
0.0	0.8	PID_EPHRINB_REV_PATHWAY	Ephrin B reverse signaling
0.0	0.8	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	0.8	PID_AP1_PATHWAY	AP-1 transcription factor network
0.0	0.6	PID_ARF_3PATHWAY	Arf1 pathway
0.0	0.6	PID_NCADHERIN_PATHWAY	N-cadherin signaling events
0.0	0.6	PID_FRA_PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	0.4	PID_IL1_PATHWAY	IL1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 13 of 13 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.6	REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.1	1.0	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	1.0	REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.9	REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1	0.8	REACTOME_ACTIVATION_OF_RAC	Genes involved in Activation of Rac
0.0	0.6	REACTOME_GAP_JUNCTION_DEGRADATION	Genes involved in Gap junction degradation
0.0	0.6	REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.6	REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	0.4	REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	0.3	REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.3	REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.2	REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.2	REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN	Genes involved in Signalling to p38 via RIT and RIN