Motif ID: Fosl2_Bach2

Z-value: 0.774

Transcription factors associated with Fosl2_Bach2:

Gene SymbolEntrez IDGene Name
Bach2 ENSMUSG00000040270.10 Bach2
Fosl2 ENSMUSG00000029135.9 Fosl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosl2mm10_v2_chr5_+_32136458_321365050.711.5e-07Click!
Bach2mm10_v2_chr4_+_32238950_322389640.296.4e-02Click!


Activity profile for motif Fosl2_Bach2.

activity profile for motif Fosl2_Bach2


Sorted Z-values histogram for motif Fosl2_Bach2

Sorted Z-values for motif Fosl2_Bach2



Network of associatons between targets according to the STRING database.



First level regulatory network of Fosl2_Bach2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_33907721 6.416 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chrY_-_1286563 4.974 ENSMUST00000091190.5
 Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr14_+_65968483 4.587 ENSMUST00000022616.6
 Clu
clusterin
chr18_+_32938955 4.291 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chr6_+_17463927 4.047 ENSMUST00000115442.1
 Met
met proto-oncogene
chr2_-_45110241 3.324 ENSMUST00000177302.1
 Zeb2
zinc finger E-box binding homeobox 2
chr14_+_101840602 3.220 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr3_-_88503187 3.134 ENSMUST00000120377.1
 Lmna
lamin A
chr9_-_20728219 3.033 ENSMUST00000034692.7
 Olfm2
olfactomedin 2
chr6_-_124769548 3.019 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
 Eno2


enolase 2, gamma neuronal


chr3_-_88503331 2.801 ENSMUST00000029699.6
 Lmna
lamin A
chr2_-_36105271 2.767 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chr6_+_124996681 2.766 ENSMUST00000032479.4
 Pianp
PILR alpha associated neural protein
chr6_-_97459279 2.753 ENSMUST00000113359.1
 Frmd4b
FERM domain containing 4B
chr13_+_54949388 2.644 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr7_-_105482197 2.605 ENSMUST00000047040.2
 Prkcdbp
protein kinase C, delta binding protein
chr14_+_101840501 2.604 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr13_-_54611332 2.480 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)
chr7_-_44670820 2.421 ENSMUST00000048102.7
 Myh14
myosin, heavy polypeptide 14
chr13_-_54611274 2.411 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.5 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.2 6.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 6.0 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
1.2 5.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.8 4.6 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.7 4.4 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 4.2 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.3 4.0 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.9 3.6 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.0 3.3 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 3.2 GO:0071625 vocalization behavior(GO:0071625)
0.1 3.1 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.6 3.0 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.2 3.0 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.3 2.9 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.5 2.8 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.3 2.6 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 2.6 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.1 2.5 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.2 2.3 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.2 GO:0001650 fibrillar center(GO:0001650)
0.0 8.2 GO:0016324 apical plasma membrane(GO:0016324)
0.1 6.5 GO:0009925 basal plasma membrane(GO:0009925)
0.8 5.9 GO:0005638 lamin filament(GO:0005638)
0.0 5.0 GO:0055037 recycling endosome(GO:0055037)
0.4 4.9 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.7 4.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 4.0 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 3.7 GO:0005604 basement membrane(GO:0005604)
0.1 3.4 GO:0031985 Golgi cisterna(GO:0031985)
0.1 3.3 GO:0042734 presynaptic membrane(GO:0042734)
0.2 3.1 GO:1990635 proximal dendrite(GO:1990635)
0.1 3.1 GO:0048786 presynaptic active zone(GO:0048786)
0.3 3.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 3.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.7 2.9 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.0 2.7 GO:0014069 postsynaptic density(GO:0014069)
0.2 2.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 2.6 GO:0032279 asymmetric synapse(GO:0032279)
0.1 2.6 GO:0032809 neuronal cell body membrane(GO:0032809)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.2 GO:0005096 GTPase activator activity(GO:0005096)
1.6 6.5 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2 6.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 5.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 5.8 GO:0042805 actinin binding(GO:0042805)
0.4 4.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 4.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 4.6 GO:0051787 misfolded protein binding(GO:0051787)
0.1 4.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.4 4.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 4.3 GO:0070412 R-SMAD binding(GO:0070412)
0.3 4.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 4.2 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 3.7 GO:0008017 microtubule binding(GO:0008017)
0.2 3.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 3.1 GO:0070064 proline-rich region binding(GO:0070064)
0.3 3.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 3.0 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 2.9 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.0 PID_ARF6_PATHWAY Arf6 signaling events
0.1 6.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 5.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 4.4 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 4.2 PID_ARF_3PATHWAY Arf1 pathway
0.1 3.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 3.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.6 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.1 2.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 2.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.9 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 1.7 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 1.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.6 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 1.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 1.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.3 PID_MTOR_4PATHWAY mTOR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.9 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 6.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.3 4.9 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 4.3 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.0 3.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 2.6 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 2.4 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.2 2.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 2.0 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 2.0 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 1.9 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.4 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 1.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.4 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.3 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.3 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 1.3 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling