Motif ID: Foxa2_Foxa1

Z-value: 1.249

Transcription factors associated with Foxa2_Foxa1:

Gene SymbolEntrez IDGene Name
Foxa1 ENSMUSG00000035451.6 Foxa1
Foxa2 ENSMUSG00000037025.5 Foxa2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxa2mm10_v2_chr2_-_148045891_1480459480.287.2e-02Click!
Foxa1mm10_v2_chr12_-_57546121_575461410.261.0e-01Click!


Activity profile for motif Foxa2_Foxa1.

activity profile for motif Foxa2_Foxa1


Sorted Z-values histogram for motif Foxa2_Foxa1

Sorted Z-values for motif Foxa2_Foxa1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxa2_Foxa1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_60177357 16.021 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr4_-_58499398 13.766 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr17_-_70851710 10.613 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr6_+_5390387 9.791 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr12_-_56535047 8.539 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr16_-_22439719 8.157 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr2_+_25180737 8.065 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr14_-_48662740 7.878 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr10_-_93310963 6.053 ENSMUST00000151153.1
 Elk3
ELK3, member of ETS oncogene family
chr14_+_73237891 5.892 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr12_-_99883429 5.732 ENSMUST00000046485.3
 Efcab11
EF-hand calcium binding domain 11
chr9_+_78615501 5.704 ENSMUST00000093812.4
 Cd109
CD109 antigen
chr6_+_15185203 5.558 ENSMUST00000154448.1
 Foxp2
forkhead box P2
chr5_+_75152274 5.539 ENSMUST00000000476.8
 Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr10_-_93311073 5.477 ENSMUST00000008542.5
 Elk3
ELK3, member of ETS oncogene family
chr3_-_145649970 5.192 ENSMUST00000029846.3
 Cyr61
cysteine rich protein 61
chr4_+_11191726 5.190 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr18_-_60501983 5.156 ENSMUST00000042710.6
 Smim3
small integral membrane protein 3
chr2_-_172940299 4.975 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr2_+_73271925 4.516 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 16.0 GO:0042473 outer ear morphogenesis(GO:0042473)
3.4 13.8 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.7 11.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
3.7 11.1 GO:0021759 globus pallidus development(GO:0021759)
0.0 10.5 GO:0042060 wound healing(GO:0042060)
0.9 9.8 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
1.8 9.0 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.5 8.8 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.3 8.5 GO:0006270 DNA replication initiation(GO:0006270)
0.8 8.4 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.7 8.1 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
2.0 7.9 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.7 7.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
2.0 6.1 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.7 5.8 GO:0033564 anterior/posterior axon guidance(GO:0033564)
1.1 5.7 GO:0072675 osteoclast fusion(GO:0072675)
1.8 5.5 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.5 5.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.3 5.2 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
1.7 5.0 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 15.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 13.8 GO:0043198 dendritic shaft(GO:0043198)
0.0 13.1 GO:0005667 transcription factor complex(GO:0005667)
2.0 9.8 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 9.7 GO:0031012 extracellular matrix(GO:0031012)
2.8 8.5 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 6.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 5.8 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 5.5 GO:0005902 microvillus(GO:0005902)
0.4 5.4 GO:0042555 MCM complex(GO:0042555)
0.6 5.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 5.1 GO:0030426 growth cone(GO:0030426)
0.0 5.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.4 4.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
1.2 3.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 3.4 GO:0005604 basement membrane(GO:0005604)
0.0 3.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 3.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.8 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.8 GO:0031965 nuclear membrane(GO:0031965)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 21.8 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
2.9 11.5 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.9 10.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.5 10.6 GO:0070410 co-SMAD binding(GO:0070410)
0.3 8.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 8.1 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.2 6.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 6.1 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 5.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.1 5.5 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.5 5.0 GO:0070700 BMP receptor binding(GO:0070700)
0.2 5.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 4.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 4.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 4.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.9 4.3 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
1.3 3.8 GO:0016015 morphogen activity(GO:0016015)
1.2 3.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 3.5 GO:0005521 lamin binding(GO:0005521)
0.7 3.4 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 24.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 15.0 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.3 11.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 11.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.7 10.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 7.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 6.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 5.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 5.4 PID_ATR_PATHWAY ATR signaling pathway
0.4 5.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.2 5.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.5 5.0 PID_ALK2_PATHWAY ALK2 signaling events
0.1 4.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 4.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.5 3.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 2.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 2.1 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 1.8 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 1.7 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.2 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.3 10.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 10.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.4 10.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.9 8.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 6.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.5 5.8 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.2 5.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.3 5.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 4.5 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 3.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 3.4 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 3.3 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.9 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 2.3 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.1 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 1.9 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.2 1.8 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.8 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling