Motif ID: Foxa3

Z-value: 1.069


Transcription factors associated with Foxa3:

Gene SymbolEntrez IDGene Name
Foxa3 ENSMUSG00000040891.5 Foxa3



Activity profile for motif Foxa3.

activity profile for motif Foxa3


Sorted Z-values histogram for motif Foxa3

Sorted Z-values for motif Foxa3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxa3

PNG image of the network

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Top targets:


Showing 1 to 20 of 174 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_53850243 14.608 ENSMUST00000048485.5
 Sln
sarcolipin
chr7_-_103813913 9.374 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr7_-_103827922 6.712 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr15_+_3270767 5.039 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr7_-_27181149 5.015 ENSMUST00000071986.6
ENSMUST00000121848.1
 Mia

melanoma inhibitory activity

chr8_-_84773381 5.007 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr1_+_17145357 4.624 ENSMUST00000026879.7
 Gdap1
ganglioside-induced differentiation-associated-protein 1
chr2_-_77519565 4.490 ENSMUST00000111830.2
 Zfp385b
zinc finger protein 385B
chr10_+_60106452 4.485 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr1_+_51289106 4.169 ENSMUST00000051572.6
 Sdpr
serum deprivation response
chr4_-_87806296 4.003 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr13_+_94173992 3.906 ENSMUST00000121618.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr8_+_69300776 3.779 ENSMUST00000078257.6
 D130040H23Rik
RIKEN cDNA D130040H23 gene
chr3_-_89764581 3.604 ENSMUST00000029562.3
 Chrnb2
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
chr4_-_116405986 3.550 ENSMUST00000123072.1
ENSMUST00000144281.1
 Mast2

microtubule associated serine/threonine kinase 2

chr9_-_103222063 3.481 ENSMUST00000170904.1
 Trf
transferrin
chr2_-_62483637 3.085 ENSMUST00000136686.1
ENSMUST00000102733.3
 Gcg

glucagon

chr18_-_62756275 2.982 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr17_+_70522083 2.893 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr13_+_16011851 2.812 ENSMUST00000042603.6
 Inhba
inhibin beta-A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 14.6 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.4 6.7 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.4 5.0 GO:0070842 aggresome assembly(GO:0070842)
0.3 5.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 4.6 GO:0008053 mitochondrial fusion(GO:0008053)
0.5 4.5 GO:0071420 cellular response to histamine(GO:0071420)
0.5 4.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 4.4 GO:0007160 cell-matrix adhesion(GO:0007160)
0.6 4.3 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.6 4.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 4.0 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 3.8 GO:0051028 mRNA transport(GO:0051028)
1.2 3.6 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.4 3.6 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.6 3.5 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.4 3.5 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.4 3.1 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.0 3.1 GO:0048813 dendrite morphogenesis(GO:0048813)
0.3 2.9 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.6 2.8 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 16.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.7 14.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 8.6 GO:0014069 postsynaptic density(GO:0014069)
0.1 6.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 6.2 GO:0001650 fibrillar center(GO:0001650)
0.2 5.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 4.8 GO:0016607 nuclear speck(GO:0016607)
0.2 4.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.3 4.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 4.3 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.3 3.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.4 3.5 GO:0097433 dense body(GO:0097433)
0.0 3.1 GO:0031965 nuclear membrane(GO:0031965)
0.9 2.8 GO:0043512 inhibin A complex(GO:0043512)
0.5 2.7 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.4 2.7 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 2.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 2.5 GO:0005902 microvillus(GO:0005902)
0.6 2.4 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.1 2.2 GO:0071564 npBAF complex(GO:0071564)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 16.1 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.1 5.2 GO:0008083 growth factor activity(GO:0008083)
0.0 5.2 GO:0008017 microtubule binding(GO:0008017)
0.1 4.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 4.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 4.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 4.1 GO:0002039 p53 binding(GO:0002039)
1.0 4.0 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.3 3.7 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.4 3.6 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.5 3.5 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 3.5 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 3.4 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.5 2.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 2.7 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 2.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 2.7 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 2.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 2.4 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 2.2 GO:0031492 nucleosomal DNA binding(GO:0031492)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 PID_SHP2_PATHWAY SHP2 signaling
0.0 3.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 3.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.1 PID_MYC_PATHWAY C-MYC pathway
0.1 3.0 PID_FOXO_PATHWAY FoxO family signaling
0.1 2.8 PID_ALK1_PATHWAY ALK1 signaling events
0.1 2.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 2.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.3 2.4 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.0 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 1.9 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 1.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.6 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 1.5 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.1 1.4 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 1.3 PID_LPA4_PATHWAY LPA4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.3 4.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.5 3.6 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2 3.1 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.7 2.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.2 2.8 REACTOME_SIGNALING_BY_NOTCH4 Genes involved in Signaling by NOTCH4
0.1 2.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 2.2 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 2.2 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.9 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 1.9 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.7 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.7 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 1.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 1.3 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 1.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 1.0 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.0 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation