Motif ID: Foxb1

Z-value: 0.860


Transcription factors associated with Foxb1:

Gene SymbolEntrez IDGene Name
Foxb1 ENSMUSG00000059246.4 Foxb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxb1mm10_v2_chr9_-_69760924_697609400.076.6e-01Click!


Activity profile for motif Foxb1.

activity profile for motif Foxb1


Sorted Z-values histogram for motif Foxb1

Sorted Z-values for motif Foxb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 100 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_55782500 5.043 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr3_-_123672321 5.027 ENSMUST00000172537.1
ENSMUST00000029602.6
 Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr10_+_26229707 4.441 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_-_158814469 4.323 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr17_+_93199348 3.542 ENSMUST00000064775.6
 Adcyap1
adenylate cyclase activating polypeptide 1
chr2_-_65529275 3.538 ENSMUST00000126837.1
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr3_-_123690806 3.323 ENSMUST00000154668.1
 Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr6_-_56362356 3.314 ENSMUST00000044505.7
ENSMUST00000166102.1
ENSMUST00000164037.1
ENSMUST00000114327.2
 Pde1c



phosphodiesterase 1C



chr2_+_55437100 3.283 ENSMUST00000112633.2
ENSMUST00000112632.1
 Kcnj3

potassium inwardly-rectifying channel, subfamily J, member 3

chr10_+_69925484 3.223 ENSMUST00000182692.1
ENSMUST00000092433.5
 Ank3

ankyrin 3, epithelial

chr10_+_69925954 3.150 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
 Ank3


ankyrin 3, epithelial


chr10_+_69925766 3.082 ENSMUST00000182269.1
ENSMUST00000183261.1
ENSMUST00000183074.1
 Ank3


ankyrin 3, epithelial


chr19_+_47228804 2.757 ENSMUST00000111807.3
 Neurl1a
neuralized homolog 1A (Drosophila)
chr10_+_69925800 2.496 ENSMUST00000182029.1
 Ank3
ankyrin 3, epithelial
chr6_+_14901344 2.461 ENSMUST00000115477.1
 Foxp2
forkhead box P2
chr18_-_47333311 2.345 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr8_+_58912257 2.303 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr1_-_72536930 2.042 ENSMUST00000047786.5
 March4
membrane-associated ring finger (C3HC4) 4
chr19_+_20601958 2.004 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr3_+_76075583 1.947 ENSMUST00000160261.1
 Fstl5
follistatin-like 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 12.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
1.4 8.3 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 4.9 GO:0060349 bone morphogenesis(GO:0060349)
0.0 3.8 GO:0043010 camera-type eye development(GO:0043010)
1.2 3.5 GO:0071649 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) positive regulation of somatostatin secretion(GO:0090274)
0.7 3.5 GO:0046684 response to pyrethroid(GO:0046684)
0.5 3.3 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.2 3.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.3 2.8 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 2.5 GO:0006342 chromatin silencing(GO:0006342)
0.1 2.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 2.2 GO:0015693 magnesium ion transport(GO:0015693)
0.5 2.0 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2 2.0 GO:0060539 diaphragm development(GO:0060539)
0.2 2.0 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.5 1.6 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 1.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 1.4 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.2 1.3 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.3 1.2 GO:0007412 axon target recognition(GO:0007412)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 12.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.2 3.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 3.5 GO:0043195 terminal bouton(GO:0043195)
0.0 3.3 GO:0030315 T-tubule(GO:0030315)
0.1 2.5 GO:0097440 apical dendrite(GO:0097440)
0.0 2.3 GO:0030424 axon(GO:0030424)
0.0 2.0 GO:0005795 Golgi stack(GO:0005795)
0.0 1.9 GO:0044291 cell-cell contact zone(GO:0044291)
0.1 1.6 GO:0030673 axolemma(GO:0030673)
0.1 1.5 GO:0031430 M band(GO:0031430)
0.0 1.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.2 GO:0044306 neuron projection terminus(GO:0044306)
0.0 1.2 GO:0042641 actomyosin(GO:0042641)
0.2 1.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.8 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 0.8 GO:0070852 cell body fiber(GO:0070852)
0.0 0.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 0.7 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 0.7 GO:0005955 calcineurin complex(GO:0005955)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.4 GO:0030507 spectrin binding(GO:0030507)
2.1 8.3 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.0 5.0 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 4.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 3.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 3.5 GO:0031402 sodium ion binding(GO:0031402)
0.7 3.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.5 3.3 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 2.8 GO:0045182 translation regulator activity(GO:0045182)
0.1 2.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 2.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.4 2.0 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.2 1.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.4 GO:0042287 MHC protein binding(GO:0042287)
0.0 1.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.3 1.2 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.1 1.1 GO:0071253 connexin binding(GO:0071253)
0.1 1.1 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 1.1 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 1.0 GO:0070412 R-SMAD binding(GO:0070412)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.3 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 2.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.2 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.2 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.2 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.7 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.6 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 8.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 4.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.5 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.2 3.3 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 2.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.5 2.0 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 1.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.7 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.2 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly