Motif ID: Foxc1

Z-value: 0.875


Transcription factors associated with Foxc1:

Gene SymbolEntrez IDGene Name
Foxc1 ENSMUSG00000050295.2 Foxc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc1mm10_v2_chr13_+_31806627_31806650-0.009.8e-01Click!


Activity profile for motif Foxc1.

activity profile for motif Foxc1


Sorted Z-values histogram for motif Foxc1

Sorted Z-values for motif Foxc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 172 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_1010543 4.983 ENSMUST00000091197.3
 Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr6_+_47244359 3.869 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chr1_+_72824482 3.726 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr7_-_75308373 3.635 ENSMUST00000085164.5
 Sv2b
synaptic vesicle glycoprotein 2 b
chr1_+_107511489 3.594 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 3.449 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_45311538 3.120 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr1_+_84839833 3.023 ENSMUST00000097672.3
 Fbxo36
F-box protein 36
chr5_+_98854434 2.960 ENSMUST00000031278.4
 Bmp3
bone morphogenetic protein 3
chr14_-_48662740 2.728 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr17_-_70851710 2.646 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr2_+_4976113 2.632 ENSMUST00000167607.1
ENSMUST00000115010.2
 Ucma

upper zone of growth plate and cartilage matrix associated

chrX_-_102252154 2.626 ENSMUST00000050551.3
 Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr19_+_60144682 2.614 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chrX_-_102251852 2.531 ENSMUST00000101336.3
ENSMUST00000136277.1
 Cited1

Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1

chr17_+_80944611 2.517 ENSMUST00000025092.4
 Tmem178
transmembrane protein 178
chr16_-_21947536 2.317 ENSMUST00000023562.7
 Tmem41a
transmembrane protein 41a
chr13_-_54766553 2.289 ENSMUST00000036825.7
 Sncb
synuclein, beta
chr3_+_94377432 2.183 ENSMUST00000107292.1
 Rorc
RAR-related orphan receptor gamma
chr13_+_53525703 2.180 ENSMUST00000081132.4
 Gm5449
predicted pseudogene 5449

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.2 GO:0010466 negative regulation of peptidase activity(GO:0010466)
1.3 5.2 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.0 4.4 GO:0006413 translational initiation(GO:0006413)
0.5 4.0 GO:0072615 interleukin-17 secretion(GO:0072615)
0.8 3.9 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.2 3.7 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.2 3.4 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 3.3 GO:0006836 neurotransmitter transport(GO:0006836)
0.6 3.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 3.0 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.7 2.7 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.2 2.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 2.5 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.1 2.4 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.1 2.3 GO:0042417 dopamine metabolic process(GO:0042417)
0.0 2.0 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.6 1.9 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1 1.9 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 1.9 GO:0007605 sensory perception of sound(GO:0007605)
0.6 1.7 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of protein import into nucleus, translocation(GO:0033159) regulation of oligodendrocyte apoptotic process(GO:1900141) negative regulation of oligodendrocyte apoptotic process(GO:1900142) positive regulation of dendritic cell chemotaxis(GO:2000510)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.0 GO:0005615 extracellular space(GO:0005615)
0.1 5.6 GO:0016234 inclusion body(GO:0016234)
0.0 3.5 GO:0043195 terminal bouton(GO:0043195)
0.3 3.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 2.9 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 2.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 2.1 GO:0032420 stereocilium(GO:0032420)
0.1 1.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.5 1.6 GO:0042585 germinal vesicle(GO:0042585)
0.5 1.6 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.4 1.3 GO:0042584 chromaffin granule membrane(GO:0042584)
0.2 1.3 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 1.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 1.3 GO:0042101 T cell receptor complex(GO:0042101)
0.3 1.1 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.0 1.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.0 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 5.2 GO:0050693 LBD domain binding(GO:0050693)
0.0 5.2 GO:0002020 protease binding(GO:0002020)
0.1 4.5 GO:0003743 translation initiation factor activity(GO:0003743)
1.0 4.0 GO:0008142 oxysterol binding(GO:0008142)
0.5 3.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 3.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 3.0 GO:0070700 BMP receptor binding(GO:0070700)
0.0 3.0 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 2.6 GO:0070410 co-SMAD binding(GO:0070410)
0.3 2.5 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.3 2.4 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.3 2.3 GO:1903136 cuprous ion binding(GO:1903136)
0.0 2.0 GO:0008083 growth factor activity(GO:0008083)
0.6 1.9 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 1.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 1.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 1.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.7 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.3 1.6 GO:0035174 histone serine kinase activity(GO:0035174)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 7.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 6.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.1 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 1.6 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.5 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.1 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 0.9 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.8 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 0.7 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.7 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.6 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.2 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.3 REACTOME_HEMOSTASIS Genes involved in Hemostasis
0.1 4.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 4.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 1.9 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.6 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 1.6 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 1.5 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 1.3 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 1.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.1 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 1.0 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 1.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.9 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.9 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins