Motif ID: Foxd1

Z-value: 1.976


Transcription factors associated with Foxd1:

Gene SymbolEntrez IDGene Name
Foxd1 ENSMUSG00000078302.3 Foxd1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxd1mm10_v2_chr13_+_98354234_98354250-0.352.5e-02Click!


Activity profile for motif Foxd1.

activity profile for motif Foxd1


Sorted Z-values histogram for motif Foxd1

Sorted Z-values for motif Foxd1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxd1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144892813 31.207 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_+_144893077 25.087 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144893127 21.601 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr10_-_8518801 14.855 ENSMUST00000061601.7
 Ust
uronyl-2-sulfotransferase
chr11_+_3332426 14.624 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr8_-_84773381 13.229 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr13_-_93499803 12.904 ENSMUST00000065537.7
 Jmy
junction-mediating and regulatory protein
chr8_+_65618009 12.063 ENSMUST00000110258.1
ENSMUST00000110256.1
ENSMUST00000110255.1
 March1


membrane-associated ring finger (C3HC4) 1


chr15_+_3270767 10.719 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr16_-_22439570 10.663 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr16_-_22439719 10.558 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr14_-_18239053 10.519 ENSMUST00000090543.5
 Nr1d2
nuclear receptor subfamily 1, group D, member 2
chr18_+_69344503 10.515 ENSMUST00000114985.3
 Tcf4
transcription factor 4
chr18_+_5593566 10.323 ENSMUST00000160910.1
 Zeb1
zinc finger E-box binding homeobox 1
chr11_+_3330781 9.885 ENSMUST00000136536.1
ENSMUST00000093399.4
 Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chr12_-_100725028 9.514 ENSMUST00000043599.6
 Rps6ka5
ribosomal protein S6 kinase, polypeptide 5
chr11_+_3330401 9.430 ENSMUST00000045153.4
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr5_+_3928033 8.762 ENSMUST00000143365.1
 Akap9
A kinase (PRKA) anchor protein (yotiao) 9
chr19_+_4855129 8.207 ENSMUST00000119694.1
 Ctsf
cathepsin F
chr7_+_141476374 8.132 ENSMUST00000117634.1
 Tspan4
tetraspanin 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.1 77.9 GO:0042572 retinol metabolic process(GO:0042572)
4.8 33.9 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
4.2 21.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 15.2 GO:0030010 establishment of cell polarity(GO:0030010)
1.5 13.5 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.7 13.4 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.7 13.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
3.2 12.9 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.6 12.1 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.6 12.0 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
1.3 11.5 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
1.0 10.5 GO:0042118 endothelial cell activation(GO:0042118)
0.7 9.6 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
3.2 9.5 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
2.5 7.5 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
2.4 7.3 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.8 7.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.7 7.1 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
1.0 6.9 GO:0035826 rubidium ion transport(GO:0035826) cellular hypotonic response(GO:0071476)
1.3 6.7 GO:0050847 progesterone receptor signaling pathway(GO:0050847)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 84.4 GO:0016021 integral component of membrane(GO:0016021)
0.1 25.9 GO:0016607 nuclear speck(GO:0016607)
0.0 13.8 GO:0005667 transcription factor complex(GO:0005667)
3.3 13.4 GO:0044307 dendritic branch(GO:0044307)
0.4 12.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 11.6 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3 11.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 11.3 GO:0031252 cell leading edge(GO:0031252)
0.6 9.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 8.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.9 7.5 GO:0033391 chromatoid body(GO:0033391)
0.1 7.4 GO:0030667 secretory granule membrane(GO:0030667)
0.2 7.3 GO:0030673 axolemma(GO:0030673)
0.3 7.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 6.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 6.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 6.6 GO:0035861 site of double-strand break(GO:0035861)
0.1 6.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 6.5 GO:0045171 intercellular bridge(GO:0045171)
0.5 6.4 GO:0030057 desmosome(GO:0030057)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
11.1 77.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
11.3 33.9 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.7 15.7 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 14.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.1 12.9 GO:0071933 Arp2/3 complex binding(GO:0071933)
1.9 11.3 GO:0004887 thyroid hormone receptor activity(GO:0004887)
2.6 10.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 10.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 10.0 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.4 9.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 8.9 GO:0045296 cadherin binding(GO:0045296)
0.1 8.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 8.1 GO:0003823 antigen binding(GO:0003823)
0.8 7.5 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.7 7.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.8 7.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 7.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 7.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.0 7.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.0 6.9 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 89.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 27.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.7 20.8 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.3 18.3 PID_FOXO_PATHWAY FoxO family signaling
0.1 12.9 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.5 11.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.7 11.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.2 10.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.4 8.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.2 7.7 PID_IL3_PATHWAY IL3-mediated signaling events
0.2 7.4 PID_IL12_2PATHWAY IL12-mediated signaling events
0.2 7.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 6.5 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 5.1 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 4.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 4.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 3.8 NABA_COLLAGENS Genes encoding collagen proteins
0.1 3.4 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 3.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 2.7 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.9 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.5 13.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 10.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.5 10.4 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.3 9.3 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 8.2 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.3 7.5 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.2 7.3 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 7.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 7.2 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.9 6.6 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.4 5.1 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 5.1 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.3 4.8 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 4.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 4.6 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 3.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 3.7 REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.6 3.6 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 3.5 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription