Motif ID: Foxd2

Z-value: 1.021


Transcription factors associated with Foxd2:

Gene SymbolEntrez IDGene Name
Foxd2 ENSMUSG00000055210.3 Foxd2



Activity profile for motif Foxd2.

activity profile for motif Foxd2


Sorted Z-values histogram for motif Foxd2

Sorted Z-values for motif Foxd2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxd2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 108 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_104114088 8.786 ENSMUST00000031249.3
 Sparcl1
SPARC-like 1
chr3_+_89520152 8.735 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr16_+_43508118 8.126 ENSMUST00000114690.1
 Zbtb20
zinc finger and BTB domain containing 20
chr14_+_101840602 7.639 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr10_+_67096456 6.843 ENSMUST00000174317.1
 Jmjd1c
jumonji domain containing 1C
chr18_+_37504264 6.678 ENSMUST00000052179.6
 Pcdhb20
protocadherin beta 20
chr14_+_101840501 6.407 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr14_-_30353468 6.159 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chrX_-_105929206 5.808 ENSMUST00000134381.1
ENSMUST00000154866.1
 Atrx

alpha thalassemia/mental retardation syndrome X-linked homolog (human)

chr14_+_80000292 5.579 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chrX_-_105929333 5.465 ENSMUST00000134507.1
ENSMUST00000137453.1
ENSMUST00000150914.1
 Atrx


alpha thalassemia/mental retardation syndrome X-linked homolog (human)


chr7_-_61982348 5.063 ENSMUST00000181804.1
ENSMUST00000181187.1
 A330076H08Rik

RIKEN cDNA A330076H08 gene

chr16_+_43235856 4.956 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20
chr18_+_37513652 4.823 ENSMUST00000061405.4
 Pcdhb21
protocadherin beta 21
chr13_-_97747373 4.540 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_-_157256682 4.270 ENSMUST00000134543.1
 Rasal2
RAS protein activator like 2
chr7_-_61982290 4.138 ENSMUST00000180481.1
 A330076H08Rik
RIKEN cDNA A330076H08 gene
chrX_+_159697308 3.966 ENSMUST00000123433.1
 Sh3kbp1
SH3-domain kinase binding protein 1
chrX_-_105929397 3.510 ENSMUST00000113573.1
ENSMUST00000130980.1
 Atrx

alpha thalassemia/mental retardation syndrome X-linked homolog (human)

chr19_+_26748268 3.216 ENSMUST00000175791.1
ENSMUST00000176698.1
ENSMUST00000177252.1
ENSMUST00000176475.1
ENSMUST00000112637.2
 Smarca2




SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 14.8 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.3 13.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 13.0 GO:0007416 synapse assembly(GO:0007416)
1.0 6.8 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 6.3 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
1.5 6.2 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 4.9 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 4.3 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 3.8 GO:0008360 regulation of cell shape(GO:0008360)
0.4 3.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.6 3.1 GO:0051026 chiasma assembly(GO:0051026)
0.4 3.1 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.5 2.9 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.4 2.9 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.6 2.8 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.3 2.7 GO:0030035 microspike assembly(GO:0030035)
0.2 2.6 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.1 2.5 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 2.4 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 2.4 GO:0032418 lysosome localization(GO:0032418)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 14.8 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.1 13.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 11.9 GO:0030175 filopodium(GO:0030175)
0.0 8.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.6 6.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.4 5.6 GO:0042581 specific granule(GO:0042581)
0.3 4.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 4.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 4.0 GO:0030139 endocytic vesicle(GO:0030139)
0.2 3.2 GO:0071564 npBAF complex(GO:0071564)
0.1 3.1 GO:0000795 synaptonemal complex(GO:0000795)
0.9 2.8 GO:0043512 inhibin A complex(GO:0043512)
0.0 2.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 2.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 2.4 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 2.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 2.1 GO:0043204 perikaryon(GO:0043204)
0.0 2.1 GO:0005770 late endosome(GO:0005770)
0.0 1.8 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.2 1.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 14.8 GO:0015616 DNA translocase activity(GO:0015616)
0.1 13.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 11.6 GO:0042805 actinin binding(GO:0042805)
0.2 8.8 GO:0050840 extracellular matrix binding(GO:0050840)
2.2 8.7 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.4 6.8 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.8 6.2 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 5.7 GO:0051015 actin filament binding(GO:0051015)
0.0 4.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 4.5 GO:0045296 cadherin binding(GO:0045296)
0.0 4.0 GO:0017124 SH3 domain binding(GO:0017124)
0.1 3.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.4 3.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 3.1 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 2.9 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.9 GO:0005179 hormone activity(GO:0005179)
0.5 2.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 2.6 GO:0035497 cAMP response element binding(GO:0035497)
0.1 2.3 GO:0005521 lamin binding(GO:0005521)
0.5 2.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 5.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 3.2 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 2.8 PID_ALK1_PATHWAY ALK1 signaling events
0.1 2.7 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 2.3 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 1.8 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.7 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.0 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 0.9 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 0.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.9 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.5 PID_IL6_7_PATHWAY IL6-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.7 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.0 6.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 4.0 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 3.2 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 3.1 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 3.1 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.2 2.9 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.7 2.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 2.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 2.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 2.3 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.0 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 1.7 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.6 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.2 1.2 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.2 1.1 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 0.9 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.9 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.7 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation