Motif ID: Foxi1_Foxo1

Z-value: 1.711

Transcription factors associated with Foxi1_Foxo1:

Gene SymbolEntrez IDGene Name
Foxi1 ENSMUSG00000047861.2 Foxi1
Foxo1 ENSMUSG00000044167.5 Foxo1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo1mm10_v2_chr3_+_52268337_52268388-0.443.8e-03Click!


Activity profile for motif Foxi1_Foxo1.

activity profile for motif Foxi1_Foxo1


Sorted Z-values histogram for motif Foxi1_Foxo1

Sorted Z-values for motif Foxi1_Foxo1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxi1_Foxo1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 42.657 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr17_-_70851710 20.908 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr16_-_22161450 14.181 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr12_+_109452833 11.798 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr17_+_29090969 11.762 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr3_+_134236483 11.285 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr18_-_47333311 10.919 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr11_+_32276400 10.126 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr16_+_30065333 9.581 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr4_+_65124174 9.228 ENSMUST00000084501.3
 Pappa
pregnancy-associated plasma protein A
chr4_-_97584605 8.769 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr10_-_92165159 8.592 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr4_-_97584612 8.463 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr7_-_103853199 8.391 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr4_+_105157339 8.209 ENSMUST00000064139.7
 Ppap2b
phosphatidic acid phosphatase type 2B
chr10_-_92162753 7.727 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr9_+_78615501 7.588 ENSMUST00000093812.4
 Cd109
CD109 antigen
chr2_+_181767040 7.096 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr4_-_143299498 7.079 ENSMUST00000030317.7
 Pdpn
podoplanin
chr14_+_73237891 7.064 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 487 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.1 42.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.2 20.9 GO:0038092 nodal signaling pathway(GO:0038092)
1.1 19.9 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
3.7 18.5 GO:0015671 oxygen transport(GO:0015671)
1.0 17.9 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
1.9 16.8 GO:0071493 cellular response to UV-B(GO:0071493)
0.5 14.3 GO:0006270 DNA replication initiation(GO:0006270)
1.3 14.0 GO:0060539 diaphragm development(GO:0060539)
0.4 13.9 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.3 12.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
1.1 12.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
2.4 12.2 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
0.5 12.2 GO:1904355 positive regulation of telomere capping(GO:1904355)
1.2 11.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
3.8 11.5 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.6 11.4 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.5 11.4 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.7 10.7 GO:0051451 myoblast migration(GO:0051451)
0.1 10.4 GO:0051028 mRNA transport(GO:0051028)
0.3 9.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 223 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 54.9 GO:0005634 nucleus(GO:0005634)
0.5 26.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
3.8 18.8 GO:0097149 centralspindlin complex(GO:0097149)
5.6 16.9 GO:0070557 PCNA-p21 complex(GO:0070557)
1.9 15.1 GO:0005833 hemoglobin complex(GO:0005833)
1.0 14.7 GO:0042555 MCM complex(GO:0042555)
0.2 14.6 GO:0005902 microvillus(GO:0005902)
0.2 13.9 GO:0005871 kinesin complex(GO:0005871)
1.5 13.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 11.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 11.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 11.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.9 10.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 9.3 GO:0000776 kinetochore(GO:0000776)
1.5 9.1 GO:0031262 Ndc80 complex(GO:0031262)
0.1 8.6 GO:0016363 nuclear matrix(GO:0016363)
0.2 7.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
1.2 7.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 7.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 6.9 GO:0030863 cortical cytoskeleton(GO:0030863)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 337 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 41.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.2 32.8 GO:0008432 JUN kinase binding(GO:0008432)
0.5 23.1 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
3.7 18.5 GO:0005344 oxygen transporter activity(GO:0005344)
5.6 16.9 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 14.4 GO:0017048 Rho GTPase binding(GO:0017048)
0.4 14.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 13.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 12.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
1.1 11.7 GO:0015250 water channel activity(GO:0015250)
0.1 11.7 GO:0051015 actin filament binding(GO:0051015)
3.8 11.5 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.7 10.6 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.4 10.1 GO:0050431 transforming growth factor beta binding(GO:0050431)
1.4 9.7 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 9.2 GO:0008026 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.9 8.9 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.3 8.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.3 8.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
2.7 8.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 46.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.5 21.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 18.3 PID_PLK1_PATHWAY PLK1 signaling events
1.9 16.9 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3 15.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 15.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.2 13.2 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.9 12.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4 12.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.4 12.4 PID_ATR_PATHWAY ATR signaling pathway
0.4 11.0 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.4 10.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.2 10.4 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.2 9.6 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.2 6.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.3 6.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.3 5.5 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 5.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 4.2 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 3.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 38.2 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 33.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.8 24.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
1.0 15.8 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.2 15.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.9 13.3 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.7 12.7 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.3 11.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.7 11.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 11.4 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.4 11.1 REACTOME_KINESINS Genes involved in Kinesins
0.2 11.1 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
1.2 10.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.3 10.3 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 10.2 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.4 9.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 8.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 8.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 8.3 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 8.3 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation