Motif ID: Foxl1

Z-value: 0.463


Transcription factors associated with Foxl1:

Gene SymbolEntrez IDGene Name
Foxl1 ENSMUSG00000097084.1 Foxl1
Foxl1 ENSMUSG00000043867.5 Foxl1



Activity profile for motif Foxl1.

activity profile for motif Foxl1


Sorted Z-values histogram for motif Foxl1

Sorted Z-values for motif Foxl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 43 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_23622502 1.730 ENSMUST00000062045.2
 Hist1h1e
histone cluster 1, H1e
chr16_+_30065333 1.722 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr6_-_23248264 1.414 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr4_+_11191726 1.319 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr10_+_26229707 1.227 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr13_+_23763660 1.139 ENSMUST00000055770.1
 Hist1h1a
histone cluster 1, H1a
chr10_-_102490418 1.026 ENSMUST00000020040.3
 Nts
neurotensin
chr6_-_147264124 0.999 ENSMUST00000052296.6
 Pthlh
parathyroid hormone-like peptide
chr15_+_43477213 0.970 ENSMUST00000022962.6
 Emc2
ER membrane protein complex subunit 2
chr17_-_91092715 0.950 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
 Nrxn1


neurexin I


chr13_+_23575753 0.840 ENSMUST00000105105.1
 Hist1h3d
histone cluster 1, H3d
chr7_+_122289297 0.839 ENSMUST00000064989.5
ENSMUST00000064921.4
 Prkcb

protein kinase C, beta

chr2_-_94264713 0.837 ENSMUST00000129661.1
 E530001K10Rik
RIKEN cDNA E530001K10 gene
chr2_-_94264745 0.735 ENSMUST00000134563.1
 E530001K10Rik
RIKEN cDNA E530001K10 gene
chr18_-_25753852 0.721 ENSMUST00000025117.6
ENSMUST00000115816.2
 Celf4

CUGBP, Elav-like family member 4

chrX_+_112604274 0.706 ENSMUST00000071814.6
 Zfp711
zinc finger protein 711
chrM_+_2743 0.639 ENSMUST00000082392.1
 mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr2_+_91256144 0.622 ENSMUST00000154959.1
ENSMUST00000059566.4
 Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr2_-_147186389 0.588 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr12_+_69963452 0.554 ENSMUST00000110560.1
 Gm3086
predicted gene 3086

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.1 GO:0016584 nucleosome positioning(GO:0016584)
0.6 1.7 GO:0021557 oculomotor nerve development(GO:0021557)
0.2 1.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 1.3 GO:0007129 synapsis(GO:0007129)
0.2 1.1 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 1.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.1 GO:0006334 nucleosome assembly(GO:0006334)
0.2 1.0 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.2 1.0 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 1.0 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 1.0 GO:0008542 visual learning(GO:0008542)
0.2 0.8 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 0.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.6 GO:0033194 response to hydroperoxide(GO:0033194)
0.2 0.5 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.2 0.5 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.4 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.4 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.0 0.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.7 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.5 GO:0000786 nucleosome(GO:0000786)
0.4 1.3 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 1.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.0 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.8 GO:0031526 brush border membrane(GO:0031526)
0.0 0.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.4 GO:0005916 fascia adherens(GO:0005916)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.7 GO:0032564 dATP binding(GO:0032564)
0.1 1.7 GO:0008432 JUN kinase binding(GO:0008432)
0.0 1.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 1.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 1.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.0 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 1.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.8 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 0.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.5 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.0 0.5 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.4 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.2 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 1.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 0.8 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 2.3 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 1.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 1.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.8 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.8 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.5 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.4 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.4 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor