Motif ID: Foxm1

Z-value: 0.749


Transcription factors associated with Foxm1:

Gene SymbolEntrez IDGene Name
Foxm1 ENSMUSG00000001517.8 Foxm1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxm1mm10_v2_chr6_+_128362919_1283630580.095.7e-01Click!


Activity profile for motif Foxm1.

activity profile for motif Foxm1


Sorted Z-values histogram for motif Foxm1

Sorted Z-values for motif Foxm1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxm1

PNG image of the network

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Top targets:


Showing 1 to 20 of 145 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_138842429 5.033 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr15_+_98167806 3.524 ENSMUST00000031914.4
 AI836003
expressed sequence AI836003
chr8_+_34807287 3.501 ENSMUST00000033930.4
 Dusp4
dual specificity phosphatase 4
chrX_-_141725181 3.501 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr1_-_79440039 3.367 ENSMUST00000049972.4
 Scg2
secretogranin II
chr2_+_65845833 3.343 ENSMUST00000053910.3
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr2_+_65845767 2.908 ENSMUST00000122912.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr10_-_130280218 2.596 ENSMUST00000061571.3
 Neurod4
neurogenic differentiation 4
chr4_-_36136463 2.515 ENSMUST00000098151.2
 Lingo2
leucine rich repeat and Ig domain containing 2
chr8_+_58912257 2.114 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr3_+_134828993 2.075 ENSMUST00000029822.4
 Tacr3
tachykinin receptor 3
chr19_-_58455161 1.871 ENSMUST00000135730.1
ENSMUST00000152507.1
 Gfra1

glial cell line derived neurotrophic factor family receptor alpha 1

chr18_-_62741387 1.751 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr19_+_25672408 1.615 ENSMUST00000053068.5
 Dmrt2
doublesex and mab-3 related transcription factor 2
chr2_+_136052180 1.594 ENSMUST00000144403.1
 Lamp5
lysosomal-associated membrane protein family, member 5
chr19_-_58455903 1.576 ENSMUST00000131877.1
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr19_-_58455398 1.490 ENSMUST00000026076.7
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr10_+_127421208 1.392 ENSMUST00000168780.1
 R3hdm2
R3H domain containing 2
chr17_+_34305883 1.370 ENSMUST00000074557.8
 H2-Eb1
histocompatibility 2, class II antigen E beta
chr10_+_112928501 1.284 ENSMUST00000180464.1
 Gm26596
predicted gene, 26596

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.0 5.0 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 4.9 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.2 3.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.7 3.4 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.0 3.3 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.2 2.6 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 2.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.3 2.1 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
0.4 1.8 GO:0060467 negative regulation of fertilization(GO:0060467)
0.2 1.8 GO:0071420 cellular response to histamine(GO:0071420)
0.4 1.6 GO:0061055 myotome development(GO:0061055)
0.1 1.4 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 1.2 GO:0006801 superoxide metabolic process(GO:0006801)
0.2 1.1 GO:0090272 negative regulation of fibroblast growth factor production(GO:0090272)
0.1 1.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 1.1 GO:0006824 cobalt ion transport(GO:0006824)
0.2 1.0 GO:0000733 DNA strand renaturation(GO:0000733)
0.1 1.0 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.3 0.9 GO:0002423 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.1 GO:0031225 anchored component of membrane(GO:0031225)
0.2 3.4 GO:0031045 dense core granule(GO:0031045)
0.0 2.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 2.1 GO:0032590 dendrite membrane(GO:0032590)
0.1 1.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.3 1.6 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 1.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.1 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 1.1 GO:0097470 ribbon synapse(GO:0097470)
0.0 1.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 1.0 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.9 GO:0005844 polysome(GO:0005844)
0.1 0.8 GO:0001739 sex chromatin(GO:0001739)
0.0 0.8 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 0.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.7 GO:0043231 intracellular membrane-bounded organelle(GO:0043231)
0.0 0.7 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.7 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.7 GO:0000795 synaptonemal complex(GO:0000795)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.2 3.5 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.2 3.4 GO:0042056 chemoattractant activity(GO:0042056)
0.1 3.3 GO:0005158 insulin receptor binding(GO:0005158)
0.1 2.1 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 1.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 1.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.1 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1 1.1 GO:0015087 cobalt ion transmembrane transporter activity(GO:0015087)
0.1 1.1 GO:0001848 complement binding(GO:0001848)
0.2 1.0 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 1.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 1.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 0.9 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.9 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.1 0.9 GO:0001618 virus receptor activity(GO:0001618)
0.1 0.8 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 0.8 GO:0005523 tropomyosin binding(GO:0005523)
0.2 0.7 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 0.7 GO:0051434 BH3 domain binding(GO:0051434)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 4.4 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 3.3 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 1.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.9 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.7 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 0.6 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.3 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 3.5 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 1.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 1.8 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 1.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.0 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 0.9 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.9 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 0.8 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 0.7 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.7 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.5 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 0.4 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.4 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.2 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins