ISMARA results: Foxo3

Motif ID: Foxo3

Z-value: 0.998

Transcription factors associated with Foxo3:

Gene Symbol	Entrez ID	Gene Name
Foxo3	ENSMUSG00000048756.5	Foxo3

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Foxo3	mm10_v2_chr10_-_42276744_42276763	0.63	1.2e-05	Click!

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Showing 1 to 20 of 103 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr8_-_84773381	12.196	ENSMUST00000109764.1	Nfix	nuclear factor I/X
chr14_-_51913393	7.057	ENSMUST00000004673.7 ENSMUST00000111632.3	Ndrg2	N-myc downstream regulated gene 2
chr16_-_22439719	6.396	ENSMUST00000079601.6	Etv5	ets variant gene 5
chr10_+_112271123	4.780	ENSMUST00000092175.2	Kcnc2	potassium voltage gated channel, Shaw-related subfamily, member 2
chr6_+_55836878	4.486	ENSMUST00000044729.6	Ccdc129	coiled-coil domain containing 129
chr11_-_101785252	4.427	ENSMUST00000164750.1 ENSMUST00000107176.1 ENSMUST00000017868.6	Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)
chr11_+_3332426	4.363	ENSMUST00000136474.1	Pik3ip1	phosphoinositide-3-kinase interacting protein 1
chr3_-_145649970	4.131	ENSMUST00000029846.3	Cyr61	cysteine rich protein 61
chr16_-_43979050	3.820	ENSMUST00000165648.1 ENSMUST00000036321.7	Zdhhc23	zinc finger, DHHC domain containing 23
chr7_-_103813913	3.763	ENSMUST00000098192.3	Hbb-bt	hemoglobin, beta adult t chain
chr10_-_93310963	3.495	ENSMUST00000151153.1	Elk3	ELK3, member of ETS oncogene family
chr2_-_51972990	3.359	ENSMUST00000145481.1 ENSMUST00000112705.2	Nmi	N-myc (and STAT) interactor
chr18_-_74961252	3.149	ENSMUST00000066532.4	Lipg	lipase, endothelial
chr10_-_93311073	3.100	ENSMUST00000008542.5	Elk3	ELK3, member of ETS oncogene family
chr5_+_66968559	3.092	ENSMUST00000127184.1	Limch1	LIM and calponin homology domains 1
chr4_-_116405986	2.974	ENSMUST00000123072.1 ENSMUST00000144281.1	Mast2	microtubule associated serine/threonine kinase 2
chr5_+_65131184	2.947	ENSMUST00000031089.5 ENSMUST00000101191.3	Klhl5	kelch-like 5
chr5_+_66968416	2.858	ENSMUST00000038188.7	Limch1	LIM and calponin homology domains 1
chr16_+_93683184	2.845	ENSMUST00000039620.6	Cbr3	carbonyl reductase 3
chr4_-_87806276	2.703	ENSMUST00000148059.1	Mllt3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 53 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	12.2	GO:0021684	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.5	10.8	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.2	6.5	GO:0010574	regulation of vascular endothelial growth factor production(GO:0010574)
2.0	6.0	GO:1902524	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.0	5.9	GO:0031032	actomyosin structure organization(GO:0031032)
0.0	5.8	GO:0001525	angiogenesis(GO:0001525)
0.3	5.4	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.4	4.8	GO:1903818	positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.6	4.4	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.8	4.1	GO:0060591	chondroblast differentiation(GO:0060591)
0.3	3.4	GO:0042182	ketone catabolic process(GO:0042182)
0.8	3.1	GO:0010986	positive regulation of lipoprotein particle clearance(GO:0010986)
0.4	3.0	GO:0045075	interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.3	2.8	GO:0072321	chaperone-mediated protein transport(GO:0072321)
0.8	2.3	GO:0071492	cellular response to UV-A(GO:0071492)
0.6	2.2	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	2.1	GO:0050729	positive regulation of inflammatory response(GO:0050729)
0.4	1.9	GO:1900170	negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.0	1.9	GO:0008360	regulation of cell shape(GO:0008360)
0.1	1.8	GO:0018345	protein palmitoylation(GO:0018345)

Gene overrepresentation in cellular_component category:

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Showing 1 to 20 of 22 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	34.5	GO:0005654	nucleoplasm(GO:0005654)
0.1	5.4	GO:0008023	transcription elongation factor complex(GO:0008023)
0.1	4.8	GO:0030673	axolemma(GO:0030673)
0.0	4.3	GO:0005769	early endosome(GO:0005769)
0.9	3.8	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	2.9	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1	2.8	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	2.3	GO:0005903	brush border(GO:0005903)
0.0	1.9	GO:0030139	endocytic vesicle(GO:0030139)
0.0	1.7	GO:0005901	caveola(GO:0005901)
0.2	1.4	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	1.4	GO:0016459	myosin complex(GO:0016459)
0.1	1.2	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.1	1.0	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.2	0.7	GO:0031251	PAN complex(GO:0031251)
0.1	0.7	GO:0032426	stereocilium tip(GO:0032426)
0.1	0.5	GO:0045179	apical cortex(GO:0045179)
0.1	0.5	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.4	GO:0005922	connexon complex(GO:0005922)
0.1	0.3	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 42 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	15.4	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.6	6.6	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.0	6.6	GO:0003712	transcription cofactor activity(GO:0003712)
0.3	4.8	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
1.5	4.4	GO:0036313	phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.2	4.1	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.9	3.8	GO:0031721	haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.8	3.1	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0	3.0	GO:0019902	phosphatase binding(GO:0019902)
0.9	2.8	GO:0000253	3-keto sterol reductase activity(GO:0000253)
0.5	2.8	GO:0097001	ceramide binding(GO:0097001)
0.0	2.8	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	2.3	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2	2.2	GO:0031957	fatty acid transporter activity(GO:0015245) very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	2.1	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0	2.1	GO:0003823	antigen binding(GO:0003823)
0.5	1.9	GO:0038049	glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0	1.9	GO:0017124	SH3 domain binding(GO:0017124)
0.1	1.8	GO:0019707	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3	1.7	GO:0005173	stem cell factor receptor binding(GO:0005173)

Gene overrepresentation in C2:CP category:

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Showing 1 to 15 of 15 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.1	PID_MYC_REPRESS_PATHWAY	Validated targets of C-MYC transcriptional repression
0.2	6.4	PID_IL12_STAT4_PATHWAY	IL12 signaling mediated by STAT4
0.3	4.1	PID_INTEGRIN2_PATHWAY	Beta2 integrin cell surface interactions
0.0	2.7	PID_LKB1_PATHWAY	LKB1 signaling events
0.0	2.4	NABA_SECRETED_FACTORS	Genes encoding secreted soluble factors
0.0	1.9	PID_ERBB1_INTERNALIZATION_PATHWAY	Internalization of ErbB1
0.0	1.8	PID_HNF3B_PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	1.8	PID_NEPHRIN_NEPH1_PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	1.7	PID_KIT_PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	1.3	PID_NETRIN_PATHWAY	Netrin-mediated signaling events
0.0	1.2	PID_CDC42_REG_PATHWAY	Regulation of CDC42 activity
0.0	1.1	PID_THROMBIN_PAR1_PATHWAY	PAR1-mediated thrombin signaling events
0.1	1.0	PID_TCR_RAS_PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	1.0	PID_GMCSF_PATHWAY	GMCSF-mediated signaling events
0.0	0.4	PID_IL6_7_PATHWAY	IL6-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 17 of 17 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.8	REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	Genes involved in Voltage gated Potassium channels
0.1	2.2	REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1	1.9	REACTOME_EGFR_DOWNREGULATION	Genes involved in EGFR downregulation
0.0	1.9	REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	1.5	REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.0	1.5	REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.2	1.4	REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	1.0	REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1	1.0	REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	1.0	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.0	1.0	REACTOME_NETRIN1_SIGNALING	Genes involved in Netrin-1 signaling
0.1	0.7	REACTOME_REGULATION_OF_COMPLEMENT_CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.5	REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	0.4	REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.0	0.4	REACTOME_GAP_JUNCTION_ASSEMBLY	Genes involved in Gap junction assembly
0.0	0.3	REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0	0.2	REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis