Motif ID: Foxp2_Foxp3

Z-value: 0.745

Transcription factors associated with Foxp2_Foxp3:

Gene SymbolEntrez IDGene Name
Foxp2 ENSMUSG00000029563.10 Foxp2
Foxp3 ENSMUSG00000039521.6 Foxp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxp2mm10_v2_chr6_+_15196949_151971020.462.3e-03Click!
Foxp3mm10_v2_chrX_+_7579666_7579693-0.251.1e-01Click!


Activity profile for motif Foxp2_Foxp3.

activity profile for motif Foxp2_Foxp3


Sorted Z-values histogram for motif Foxp2_Foxp3

Sorted Z-values for motif Foxp2_Foxp3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxp2_Foxp3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_66386292 10.314 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr4_+_144892813 7.207 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_+_144893077 6.057 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr11_+_3332426 5.819 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr4_+_144893127 5.237 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_-_87806296 4.670 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr1_+_66386968 4.608 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chr3_+_5218516 4.498 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr6_+_141524379 3.868 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr2_+_28641227 3.862 ENSMUST00000028155.5
ENSMUST00000113869.1
ENSMUST00000113867.2
 Tsc1


tuberous sclerosis 1


chr15_-_58214882 3.846 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr19_+_4855129 3.743 ENSMUST00000119694.1
 Ctsf
cathepsin F
chr10_+_60106452 3.652 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr8_+_34807287 3.651 ENSMUST00000033930.4
 Dusp4
dual specificity phosphatase 4
chr3_+_5218589 3.570 ENSMUST00000177488.1
 Zfhx4
zinc finger homeodomain 4
chr1_+_34005872 3.466 ENSMUST00000182296.1
 Dst
dystonin
chr18_+_5593566 3.444 ENSMUST00000160910.1
 Zeb1
zinc finger E-box binding homeobox 1
chr11_-_86993682 3.354 ENSMUST00000018571.4
 Ypel2
yippee-like 2 (Drosophila)
chr5_+_3928033 3.230 ENSMUST00000143365.1
 Akap9
A kinase (PRKA) anchor protein (yotiao) 9
chr11_+_69095217 3.100 ENSMUST00000101004.2
 Per1
period circadian clock 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 219 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 18.5 GO:0042572 retinol metabolic process(GO:0042572)
0.5 10.3 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
1.2 8.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.5 7.6 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.4 6.3 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 5.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
1.7 5.1 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.4 5.0 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.3 4.9 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.1 4.7 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.4 4.6 GO:0070842 aggresome assembly(GO:0070842)
1.1 4.4 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069)
0.5 4.3 GO:0060137 maternal process involved in parturition(GO:0060137)
0.2 4.1 GO:0008090 retrograde axonal transport(GO:0008090)
1.3 3.9 GO:0043379 rRNA export from nucleus(GO:0006407) memory T cell differentiation(GO:0043379) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.4 3.9 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
1.3 3.8 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.5 3.8 GO:0035826 rubidium ion transport(GO:0035826) cellular hypotonic response(GO:0071476)
0.4 3.8 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.3 3.8 GO:0015721 bile acid and bile salt transport(GO:0015721)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.3 11.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 11.0 GO:0014069 postsynaptic density(GO:0014069)
0.0 9.5 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 7.9 GO:0016607 nuclear speck(GO:0016607)
0.2 6.8 GO:0035861 site of double-strand break(GO:0035861)
0.1 6.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.6 5.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
1.2 4.9 GO:0044307 dendritic branch(GO:0044307)
0.2 4.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.3 4.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
1.0 4.1 GO:0031673 H zone(GO:0031673)
1.3 3.9 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.3 3.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 3.8 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 3.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 3.7 GO:0005802 trans-Golgi network(GO:0005802)
0.3 3.5 GO:0030057 desmosome(GO:0030057)
0.1 3.3 GO:0031941 filamentous actin(GO:0031941)
0.1 3.2 GO:0016323 basolateral plasma membrane(GO:0016323)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 160 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 18.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.4 9.6 GO:0042287 MHC protein binding(GO:0042287)
0.0 8.7 GO:0005509 calcium ion binding(GO:0005509)
2.7 8.1 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.3 6.8 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.6 5.2 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.4 4.8 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.6 4.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.2 4.3 GO:0031402 sodium ion binding(GO:0031402)
0.1 4.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 4.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 4.0 GO:0017075 syntaxin-1 binding(GO:0017075)
1.0 3.9 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 3.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 3.9 GO:0030507 spectrin binding(GO:0030507)
0.4 3.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 3.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.9 3.6 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
1.1 3.4 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.4 3.3 GO:0035374 chondroitin sulfate binding(GO:0035374)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 23.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 7.7 PID_FOXO_PATHWAY FoxO family signaling
0.1 7.5 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 6.6 PID_LKB1_PATHWAY LKB1 signaling events
0.1 4.5 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 4.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.3 ST_ADRENERGIC Adrenergic Pathway
0.1 3.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 3.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 3.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 3.0 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 2.7 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 2.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 2.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 2.3 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 1.6 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.6 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.5 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 1.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.5 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 4.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 4.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 4.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 4.2 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 4.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3 4.0 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.5 3.9 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 3.8 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.3 3.1 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.2 2.9 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.3 2.8 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 2.4 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 2.4 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 2.3 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 2.1 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.7 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 1.7 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.7 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Early Phase of HIV Life Cycle
0.1 1.6 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism