Motif ID: Gata2_Gata1

Z-value: 0.750

Transcription factors associated with Gata2_Gata1:

Gene SymbolEntrez IDGene Name
Gata1 ENSMUSG00000031162.8 Gata1
Gata2 ENSMUSG00000015053.8 Gata2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata2mm10_v2_chr6_+_88198656_881986750.314.6e-02Click!
Gata1mm10_v2_chrX_-_7967817_79679100.221.7e-01Click!


Activity profile for motif Gata2_Gata1.

activity profile for motif Gata2_Gata1


Sorted Z-values histogram for motif Gata2_Gata1

Sorted Z-values for motif Gata2_Gata1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata2_Gata1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 148 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_116309639 6.177 ENSMUST00000036060.6
 Isl1
ISL1 transcription factor, LIM/homeodomain
chr16_+_45094036 5.799 ENSMUST00000061050.5
 Ccdc80
coiled-coil domain containing 80
chr16_+_45093611 5.760 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr11_+_90030295 4.360 ENSMUST00000092788.3
 Tmem100
transmembrane protein 100
chr2_+_72476159 3.886 ENSMUST00000102691.4
 Cdca7
cell division cycle associated 7
chr2_+_72476225 3.421 ENSMUST00000157019.1
 Cdca7
cell division cycle associated 7
chr14_-_54577578 3.418 ENSMUST00000054487.8
 Ajuba
ajuba LIM protein
chr7_-_4522427 3.395 ENSMUST00000098859.3
 Tnni3
troponin I, cardiac 3
chr3_-_154330543 3.171 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr2_-_36104060 3.036 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chr1_-_162866502 2.994 ENSMUST00000046049.7
 Fmo1
flavin containing monooxygenase 1
chr4_+_11579647 2.625 ENSMUST00000180239.1
 Fsbp
fibrinogen silencer binding protein
chr1_+_172341197 2.623 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr8_+_84701430 2.571 ENSMUST00000037165.4
 Lyl1
lymphoblastomic leukemia 1
chr6_+_17306335 2.493 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr7_-_139582790 2.429 ENSMUST00000106095.2
 Nkx6-2
NK6 homeobox 2
chr19_-_42202150 2.394 ENSMUST00000018966.7
 Sfrp5
secreted frizzled-related sequence protein 5
chr3_+_135825788 2.212 ENSMUST00000167390.1
 Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr4_-_14621805 2.175 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chrX_-_107403295 2.155 ENSMUST00000033591.5
 Itm2a
integral membrane protein 2A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.8 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
2.1 6.2 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.9 5.3 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.5 4.4 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.6 4.1 GO:0019532 oxalate transport(GO:0019532)
0.6 3.8 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.5 3.4 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.7 3.3 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.0 3.1 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.5 3.0 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.2 3.0 GO:0070995 toxin metabolic process(GO:0009404) NADPH oxidation(GO:0070995)
0.7 2.6 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.4 2.6 GO:0001955 blood vessel maturation(GO:0001955)
0.8 2.4 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.3 2.4 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.2 2.4 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.4 2.2 GO:0002317 plasma cell differentiation(GO:0002317) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.7 2.0 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 1.8 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 1.8 GO:0035855 megakaryocyte development(GO:0035855)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 10.6 GO:0005614 interstitial matrix(GO:0005614)
1.3 5.3 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 4.4 GO:0043204 perikaryon(GO:0043204)
0.0 3.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.3 3.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.5 3.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 2.4 GO:0097449 astrocyte projection(GO:0097449)
0.1 2.4 GO:0031528 microvillus membrane(GO:0031528)
0.1 2.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 2.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 1.1 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 1.0 GO:0098533 ATPase dependent transmembrane transport complex(GO:0098533)
0.0 1.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.5 GO:0045298 tubulin complex(GO:0045298)
0.1 0.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.4 GO:0030870 Mre11 complex(GO:0030870)
0.1 0.3 GO:0071438 invadopodium membrane(GO:0071438)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.3 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.4 11.6 GO:0001968 fibronectin binding(GO:0001968)
0.2 6.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
1.8 5.3 GO:0030172 troponin C binding(GO:0030172)
0.4 4.1 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.3 3.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.7 3.3 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.6 3.0 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.9 2.6 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 2.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 2.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 2.2 GO:0001540 beta-amyloid binding(GO:0001540)
0.3 2.1 GO:0001849 complement component C1q binding(GO:0001849)
0.4 2.0 GO:0015265 urea channel activity(GO:0015265)
0.1 1.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.9 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 1.8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.6 1.7 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.3 1.7 GO:0016936 galactoside binding(GO:0016936)
0.0 1.7 GO:0005179 hormone activity(GO:0005179)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 5.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.3 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 2.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.2 PID_EPO_PATHWAY EPO signaling pathway
0.0 1.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.1 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 1.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.3 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.2 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.5 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
0.4 6.2 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 4.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 3.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 3.0 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 2.6 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 2.4 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 2.0 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 1.5 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 1.5 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.1 1.4 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.2 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.2 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery
0.0 1.0 REACTOME_TRNA_AMINOACYLATION Genes involved in tRNA Aminoacylation
0.0 0.8 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.4 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.4 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.4 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway