Motif ID: Gata3

Z-value: 1.633


Transcription factors associated with Gata3:

Gene SymbolEntrez IDGene Name
Gata3 ENSMUSG00000015619.10 Gata3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata3mm10_v2_chr2_-_9878580_9878607-0.192.3e-01Click!


Activity profile for motif Gata3.

activity profile for motif Gata3


Sorted Z-values histogram for motif Gata3

Sorted Z-values for motif Gata3



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 6.983 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr10_-_102490418 5.381 ENSMUST00000020040.3
 Nts
neurotensin
chr3_+_102010138 5.221 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr14_+_67234620 5.164 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr4_+_9269285 4.385 ENSMUST00000038841.7
 Clvs1
clavesin 1
chr1_-_155417394 4.110 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr17_-_91092715 4.109 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
 Nrxn1


neurexin I


chr1_+_66386968 3.999 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chr9_+_27299205 3.949 ENSMUST00000115247.1
ENSMUST00000133213.1
 Igsf9b

immunoglobulin superfamily, member 9B

chr19_+_41482632 3.914 ENSMUST00000067795.5
 Lcor
ligand dependent nuclear receptor corepressor
chr2_-_65567465 3.898 ENSMUST00000066432.5
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr2_-_65567505 3.874 ENSMUST00000100069.2
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr7_-_75308373 3.818 ENSMUST00000085164.5
 Sv2b
synaptic vesicle glycoprotein 2 b
chr9_+_65265173 3.808 ENSMUST00000048762.1
 Cilp
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr19_+_23758819 3.704 ENSMUST00000025830.7
 Apba1
amyloid beta (A4) precursor protein binding, family A, member 1
chr2_+_136892168 3.679 ENSMUST00000099311.2
 Slx4ip
SLX4 interacting protein
chr3_+_94478831 3.579 ENSMUST00000029784.5
 Celf3
CUGBP, Elav-like family member 3
chr11_+_32276400 3.558 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr11_-_72489904 3.547 ENSMUST00000045303.3
 Spns2
spinster homolog 2
chr8_-_8639363 3.546 ENSMUST00000152698.1
 Efnb2
ephrin B2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 411 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 13.7 GO:0015671 oxygen transport(GO:0015671)
0.1 10.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 9.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.7 8.1 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.4 8.1 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
1.6 7.8 GO:0046684 response to pyrethroid(GO:0046684)
0.6 7.0 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
1.1 6.6 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.3 6.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.9 6.5 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.4 6.5 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
0.7 6.4 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 6.4 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.3 6.2 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.4 6.0 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.2 6.0 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
1.5 5.9 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
1.4 5.4 GO:1903294 axon target recognition(GO:0007412) regulation of glutamate secretion, neurotransmission(GO:1903294) positive regulation of glutamate secretion, neurotransmission(GO:1903296)
0.4 5.3 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 5.2 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 179 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 24.9 GO:0060076 excitatory synapse(GO:0060076)
0.4 14.0 GO:0030673 axolemma(GO:0030673)
0.1 12.0 GO:0043679 axon terminus(GO:0043679)
1.4 11.5 GO:0005833 hemoglobin complex(GO:0005833)
0.1 9.2 GO:0055037 recycling endosome(GO:0055037)
0.6 9.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 9.0 GO:0005905 clathrin-coated pit(GO:0005905)
0.3 8.9 GO:0060077 inhibitory synapse(GO:0060077)
0.9 8.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 7.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.8 7.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.6 6.9 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.3 6.9 GO:0031430 M band(GO:0031430)
0.1 5.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 4.8 GO:0008180 COP9 signalosome(GO:0008180)
0.1 4.8 GO:0008021 synaptic vesicle(GO:0008021)
0.2 4.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.4 4.4 GO:0070852 cell body fiber(GO:0070852)
0.1 4.3 GO:0043204 perikaryon(GO:0043204)
0.4 4.2 GO:0070545 PeBoW complex(GO:0070545)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 265 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 13.7 GO:0005344 oxygen transporter activity(GO:0005344)
0.5 9.6 GO:0031402 sodium ion binding(GO:0031402)
0.2 9.1 GO:0030507 spectrin binding(GO:0030507)
0.3 7.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.4 7.7 GO:0004708 MAP kinase kinase activity(GO:0004708)
2.2 6.6 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.9 6.6 GO:0099609 microtubule lateral binding(GO:0099609)
0.6 6.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.3 5.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 5.9 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 5.8 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 5.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 5.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 4.9 GO:0070840 dynein complex binding(GO:0070840)
0.2 4.8 GO:0070064 proline-rich region binding(GO:0070064)
0.9 4.7 GO:0043532 angiostatin binding(GO:0043532)
0.8 4.7 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 4.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 4.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.4 4.5 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.2 PID_REELIN_PATHWAY Reelin signaling pathway
0.2 9.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 6.9 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 5.4 PID_LKB1_PATHWAY LKB1 signaling events
0.1 5.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 4.7 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.2 4.2 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 4.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.3 3.7 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 2.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 2.6 PID_BCR_5PATHWAY BCR signaling pathway
0.1 2.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.4 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.3 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.1 2.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 2.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 2.1 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 1.9 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 1.9 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.9 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.2 6.8 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 6.8 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 6.6 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.2 6.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.2 6.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 6.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 6.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 6.0 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.6 5.8 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.3 5.4 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 5.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.4 5.1 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 4.5 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 4.1 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.3 3.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 3.4 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 3.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 2.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 2.7 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac