Motif ID: Gbx1_Nobox_Alx3

Z-value: 0.608

Transcription factors associated with Gbx1_Nobox_Alx3:

Gene SymbolEntrez IDGene Name
Alx3 ENSMUSG00000014603.1 Alx3
Gbx1 ENSMUSG00000067724.4 Gbx1
Nobox ENSMUSG00000029736.9 Nobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Alx3mm10_v2_chr3_+_107595031_107595164-0.211.8e-01Click!
Gbx1mm10_v2_chr5_-_24527276_245272760.114.9e-01Click!


Activity profile for motif Gbx1_Nobox_Alx3.

activity profile for motif Gbx1_Nobox_Alx3


Sorted Z-values histogram for motif Gbx1_Nobox_Alx3

Sorted Z-values for motif Gbx1_Nobox_Alx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx1_Nobox_Alx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 5.587 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr11_-_98053415 4.870 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chrX_-_143933089 3.875 ENSMUST00000087313.3
 Dcx
doublecortin
chr1_-_158356258 3.330 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr12_+_52699297 3.107 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chr12_+_38780817 2.979 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr12_+_38780284 2.873 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr3_+_55782500 2.751 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr7_+_126950518 2.651 ENSMUST00000106335.1
ENSMUST00000146017.1
 Sez6l2

seizure related 6 homolog like 2

chr10_+_127421208 2.402 ENSMUST00000168780.1
 R3hdm2
R3H domain containing 2
chr18_+_23415400 2.391 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr1_-_155417394 2.366 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr7_+_126950687 2.292 ENSMUST00000106333.1
 Sez6l2
seizure related 6 homolog like 2
chr5_-_62766153 2.259 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_72284367 2.184 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr16_-_37384915 2.180 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr12_+_109545390 2.153 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr8_+_23669653 2.111 ENSMUST00000042352.4
 Zmat4
zinc finger, matrin type 4
chr12_-_83487708 2.042 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr15_+_18818895 2.021 ENSMUST00000166873.2
 Cdh10
cadherin 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 148 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 9.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 5.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.4 5.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.7 5.6 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 5.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 4.0 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.8 3.2 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.8 3.1 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.3 2.8 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.5 2.7 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 2.7 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 2.6 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.1 2.2 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 2.2 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.5 1.9 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.2 1.9 GO:0050957 equilibrioception(GO:0050957)
0.0 1.8 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 1.8 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 1.8 GO:0035264 multicellular organism growth(GO:0035264)
0.1 1.7 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.1 GO:0030426 growth cone(GO:0030426)
0.1 3.8 GO:0031672 A band(GO:0031672)
0.0 3.7 GO:0014069 postsynaptic density(GO:0014069)
0.2 3.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 2.8 GO:0071565 nBAF complex(GO:0071565)
0.2 2.7 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 2.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.9 GO:0032420 stereocilium(GO:0032420)
0.4 1.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.3 1.4 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 1.4 GO:0005844 polysome(GO:0005844)
0.1 1.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 1.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 1.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.2 GO:0031045 dense core granule(GO:0031045)
0.0 1.2 GO:0035371 microtubule plus-end(GO:0035371)
0.1 1.1 GO:0097433 dense body(GO:0097433)
0.1 1.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 1.1 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.0 GO:0042622 photoreceptor outer segment membrane(GO:0042622)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.0 GO:0008017 microtubule binding(GO:0008017)
0.0 7.9 GO:0008270 zinc ion binding(GO:0008270)
0.0 7.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 5.6 GO:0005509 calcium ion binding(GO:0005509)
0.2 3.6 GO:0050692 DBD domain binding(GO:0050692)
0.0 3.6 GO:0019905 syntaxin binding(GO:0019905)
0.1 3.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 3.2 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.2 3.1 GO:0043495 protein anchor(GO:0043495)
0.4 2.8 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.9 2.7 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 2.7 GO:0002039 p53 binding(GO:0002039)
0.0 2.7 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.8 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.1 1.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.5 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 1.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 5.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.5 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.2 PID_ARF6_PATHWAY Arf6 signaling events
0.0 2.0 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 1.4 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 1.0 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.7 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.6 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.4 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.4 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.3 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.2 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.2 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.9 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 5.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.4 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.4 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.1 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 1.0 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events
0.0 1.0 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 1.0 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.0 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.9 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.1 0.8 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 0.8 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.8 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.8 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 0.6 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.6 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells