Motif ID: Gbx2

Z-value: 0.545


Transcription factors associated with Gbx2:

Gene SymbolEntrez IDGene Name
Gbx2 ENSMUSG00000034486.7 Gbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gbx2mm10_v2_chr1_-_89933290_89933290-0.391.1e-02Click!


Activity profile for motif Gbx2.

activity profile for motif Gbx2


Sorted Z-values histogram for motif Gbx2

Sorted Z-values for motif Gbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 52 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_59170978 5.906 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr3_-_116129615 5.902 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr16_-_22439719 3.541 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr11_+_59306920 2.279 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr14_-_48667508 2.248 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chrM_-_14060 1.635 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr12_+_79297345 1.607 ENSMUST00000079533.5
ENSMUST00000171210.1
 Rad51b

RAD51 homolog B

chr13_-_97747373 1.530 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr11_-_79504078 1.507 ENSMUST00000164465.2
 Omg
oligodendrocyte myelin glycoprotein
chr3_-_141982224 1.463 ENSMUST00000029948.8
 Bmpr1b
bone morphogenetic protein receptor, type 1B
chr16_-_36784924 1.412 ENSMUST00000168279.1
ENSMUST00000164579.1
ENSMUST00000023616.2
 Slc15a2


solute carrier family 15 (H+/peptide transporter), member 2


chr18_+_56432116 1.299 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chrX_+_106920618 1.256 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr7_-_30664986 1.230 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chr3_+_94372794 1.190 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr12_+_111814170 1.178 ENSMUST00000021714.7
 Zfyve21
zinc finger, FYVE domain containing 21
chr1_-_128102412 1.155 ENSMUST00000112538.1
ENSMUST00000086614.5
 Zranb3

zinc finger, RAN-binding domain containing 3

chr1_+_71652837 1.060 ENSMUST00000097699.2
 Apol7d
apolipoprotein L 7d
chr2_+_152754156 0.998 ENSMUST00000010020.5
 Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr11_-_5878207 0.893 ENSMUST00000102922.3
 Pold2
polymerase (DNA directed), delta 2, regulatory subunit

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.9 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.5 5.9 GO:0061032 visceral serous pericardium development(GO:0061032)
0.7 3.5 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 2.3 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.6 2.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.4 2.0 GO:0042891 antibiotic transport(GO:0042891) dipeptide transport(GO:0042938)
0.3 1.6 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.4 1.5 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 1.5 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 1.3 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.4 1.2 GO:0036292 DNA rewinding(GO:0036292)
0.1 1.2 GO:0072615 interleukin-17 secretion(GO:0072615)
0.0 1.2 GO:0051225 spindle assembly(GO:0051225)
0.1 1.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.9 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.2 0.8 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.1 0.7 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.0 0.6 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.1 0.5 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.4 GO:0006106 fumarate metabolic process(GO:0006106)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 GO:0002102 podosome(GO:0002102)
0.0 5.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.3 1.6 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 1.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.3 GO:0070469 respiratory chain(GO:0070469)
0.2 1.2 GO:0070652 HAUS complex(GO:0070652)
0.0 1.2 GO:0043596 nuclear replication fork(GO:0043596)
0.1 1.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 0.9 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.0 0.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.4 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.4 GO:0045120 pronucleus(GO:0045120)
0.0 0.3 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 5.9 GO:0008131 primary amine oxidase activity(GO:0008131)
0.7 5.9 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1 2.3 GO:0005109 frizzled binding(GO:0005109)
0.0 2.2 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.7 2.0 GO:0042936 dipeptide transporter activity(GO:0042936)
0.2 1.6 GO:0000150 recombinase activity(GO:0000150)
0.1 1.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 1.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 1.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.3 1.2 GO:0008142 oxysterol binding(GO:0008142)
0.1 1.2 GO:0036310 annealing helicase activity(GO:0036310)
0.0 1.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.7 GO:0005518 collagen binding(GO:0005518)
0.1 0.6 GO:0050436 microfibril binding(GO:0050436)
0.2 0.5 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.4 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 0.3 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.9 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 3.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 2.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.5 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 1.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.9 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 2.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.9 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 0.8 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation