Motif ID: Gcm1

Z-value: 0.459


Transcription factors associated with Gcm1:

Gene SymbolEntrez IDGene Name
Gcm1 ENSMUSG00000023333.7 Gcm1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gcm1mm10_v2_chr9_+_78051938_780519580.153.4e-01Click!


Activity profile for motif Gcm1.

activity profile for motif Gcm1


Sorted Z-values histogram for motif Gcm1

Sorted Z-values for motif Gcm1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gcm1

PNG image of the network

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Top targets:


Showing 1 to 20 of 64 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_6065538 2.196 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr11_+_101246960 1.659 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chrX_+_73503074 1.457 ENSMUST00000114479.1
ENSMUST00000088429.1
ENSMUST00000033744.5
 Atp2b3


ATPase, Ca++ transporting, plasma membrane 3


chr19_+_6400523 1.382 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2



chr12_-_119238794 1.235 ENSMUST00000026360.8
 Itgb8
integrin beta 8
chr4_-_136956784 1.211 ENSMUST00000030420.8
 Epha8
Eph receptor A8
chr7_+_46396439 1.179 ENSMUST00000025202.6
 Kcnc1
potassium voltage gated channel, Shaw-related subfamily, member 1
chr13_+_8202860 0.895 ENSMUST00000064473.6
 Adarb2
adenosine deaminase, RNA-specific, B2
chr5_-_110343009 0.885 ENSMUST00000058016.9
ENSMUST00000112478.3
 P2rx2

purinergic receptor P2X, ligand-gated ion channel, 2

chr16_-_91597636 0.878 ENSMUST00000023686.8
 Tmem50b
transmembrane protein 50B
chr7_-_99182681 0.862 ENSMUST00000033001.4
 Dgat2
diacylglycerol O-acyltransferase 2
chr13_+_8202922 0.682 ENSMUST00000123187.1
 Adarb2
adenosine deaminase, RNA-specific, B2
chr15_-_10470490 0.643 ENSMUST00000136591.1
 Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr18_-_39487096 0.612 ENSMUST00000097592.2
ENSMUST00000115571.1
 Nr3c1

nuclear receptor subfamily 3, group C, member 1

chr7_+_119900099 0.594 ENSMUST00000106516.1
 Lyrm1
LYR motif containing 1
chr16_-_3907651 0.569 ENSMUST00000177221.1
ENSMUST00000177323.1
 1700037C18Rik

RIKEN cDNA 1700037C18 gene

chr13_-_95250166 0.559 ENSMUST00000162153.1
ENSMUST00000160957.2
ENSMUST00000159598.1
ENSMUST00000162412.1
 Pde8b



phosphodiesterase 8B



chr17_+_8311101 0.551 ENSMUST00000154553.1
 Sft2d1
SFT2 domain containing 1
chr1_-_79761752 0.549 ENSMUST00000113512.1
ENSMUST00000113513.1
ENSMUST00000113515.1
ENSMUST00000113514.1
ENSMUST00000113510.1
ENSMUST00000113511.1
ENSMUST00000048820.7
 Wdfy1






WD repeat and FYVE domain containing 1






chr19_+_6400611 0.540 ENSMUST00000113467.1
 Rasgrp2
RAS, guanyl releasing protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.2 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
0.0 1.9 GO:0071277 cellular response to calcium ion(GO:0071277)
0.3 1.7 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.3 1.5 GO:1990034 calcium ion export from cell(GO:1990034)
0.1 1.2 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 1.2 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.1 1.2 GO:0001573 ganglioside metabolic process(GO:0001573)
0.1 0.9 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
0.1 0.9 GO:0014832 urinary bladder smooth muscle contraction(GO:0014832)
0.1 0.7 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.2 0.6 GO:0035106 operant conditioning(GO:0035106)
0.1 0.6 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 0.5 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0 0.5 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.5 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.2 0.4 GO:1902263 apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.0 0.4 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.3 GO:0010985 negative regulation of lipoprotein particle clearance(GO:0010985)
0.0 0.3 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.1 GO:0042713 sperm ejaculation(GO:0042713)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 GO:0051233 spindle midzone(GO:0051233)
0.3 1.7 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.1 1.2 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 1.2 GO:0030673 axolemma(GO:0030673)
0.1 0.9 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.9 GO:0005811 lipid particle(GO:0005811)
0.1 0.5 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 GO:0043274 phospholipase binding(GO:0043274)
0.2 1.8 GO:0004000 adenosine deaminase activity(GO:0004000)
0.3 1.7 GO:0097643 amylin receptor activity(GO:0097643)
0.1 1.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.2 1.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.2 1.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 1.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 0.9 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.1 0.9 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) mercury ion binding(GO:0045340)
0.2 0.6 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.5 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0 0.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.4 GO:0070840 dynein complex binding(GO:0070840)
0.1 0.3 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.2 GO:0031208 POZ domain binding(GO:0031208)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 1.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.2 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 0.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.3 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.3 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 2.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.9 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.5 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.9 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 0.6 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression