Motif ID: Gcm2

Z-value: 1.945


Transcription factors associated with Gcm2:

Gene SymbolEntrez IDGene Name
Gcm2 ENSMUSG00000021362.6 Gcm2



Activity profile for motif Gcm2.

activity profile for motif Gcm2


Sorted Z-values histogram for motif Gcm2

Sorted Z-values for motif Gcm2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gcm2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_6065737 19.831 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr11_-_6065538 12.389 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr7_+_121392266 9.526 ENSMUST00000084628.3
 Hs3st2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr12_-_79007276 8.885 ENSMUST00000056660.6
ENSMUST00000174721.1
 Tmem229b

transmembrane protein 229B

chr9_+_54764748 8.136 ENSMUST00000034830.8
 Crabp1
cellular retinoic acid binding protein I
chr15_-_66831625 7.943 ENSMUST00000164163.1
 Sla
src-like adaptor
chr2_-_32353247 6.375 ENSMUST00000078352.5
ENSMUST00000113352.2
ENSMUST00000113365.1
 Dnm1


dynamin 1


chr11_+_98348404 6.162 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr2_+_82053222 6.147 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chr11_-_116654245 5.271 ENSMUST00000021166.5
 Cygb
cytoglobin
chr3_+_96596628 5.062 ENSMUST00000058943.7
 Ankrd34a
ankyrin repeat domain 34A
chr9_+_112234257 5.013 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
 2900079G21Rik


RIKEN cDNA 2900079G21 gene


chr7_+_57591147 4.903 ENSMUST00000039697.7
 Gabrb3
gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
chr4_+_85205120 4.893 ENSMUST00000107188.3
 Sh3gl2
SH3-domain GRB2-like 2
chr5_+_110544326 4.772 ENSMUST00000040001.7
 Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr2_-_32353283 4.470 ENSMUST00000091089.5
ENSMUST00000113350.1
 Dnm1

dynamin 1

chr19_+_54045182 4.452 ENSMUST00000036700.5
 Adra2a
adrenergic receptor, alpha 2a
chr5_+_118027743 4.287 ENSMUST00000031304.7
 Tesc
tescalcin
chr11_-_66525964 4.201 ENSMUST00000066679.6
 Shisa6
shisa homolog 6 (Xenopus laevis)
chr18_-_61911783 4.099 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 459 entries
Log-likelihood per target Total log-likelihoodTermDescription
10.7 32.2 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
1.5 10.8 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
1.5 10.8 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.3 8.2 GO:0071625 vocalization behavior(GO:0071625)
2.7 8.1 GO:0016115 terpenoid catabolic process(GO:0016115)
0.4 7.7 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.2 7.5 GO:0001881 receptor recycling(GO:0001881)
0.1 6.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
2.1 6.2 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 6.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.2 5.8 GO:0060074 synapse maturation(GO:0060074)
0.1 5.7 GO:0015807 L-amino acid transport(GO:0015807)
0.2 5.6 GO:0048148 behavioral response to cocaine(GO:0048148)
0.8 5.4 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
1.1 5.3 GO:0015671 oxygen transport(GO:0015671)
0.0 5.2 GO:0006887 exocytosis(GO:0006887)
1.3 5.1 GO:0035624 receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.7 5.1 GO:0035902 response to immobilization stress(GO:0035902)
0.2 5.0 GO:0060749 mammary gland alveolus development(GO:0060749) mammary gland lobule development(GO:0061377)
0.5 4.9 GO:0071420 cellular response to histamine(GO:0071420)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 195 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 29.4 GO:0051233 spindle midzone(GO:0051233)
1.4 21.8 GO:0043196 varicosity(GO:0043196)
0.2 16.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 14.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 13.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 12.3 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 10.5 GO:0031225 anchored component of membrane(GO:0031225)
0.7 9.8 GO:0043083 synaptic cleft(GO:0043083)
0.0 9.6 GO:0043025 neuronal cell body(GO:0043025)
0.1 9.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 7.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 5.8 GO:0008021 synaptic vesicle(GO:0008021)
0.1 5.6 GO:0005769 early endosome(GO:0005769)
0.1 5.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.5 5.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.2 5.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 4.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 4.9 GO:0000139 Golgi membrane(GO:0000139)
0.0 4.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.6 4.6 GO:0097433 dense body(GO:0097433)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 308 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 33.7 GO:0043274 phospholipase binding(GO:0043274)
0.7 13.1 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
1.0 12.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
1.4 10.8 GO:0031749 D2 dopamine receptor binding(GO:0031749)
1.4 8.3 GO:0019841 retinol binding(GO:0019841)
1.0 7.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.2 7.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
2.3 6.8 GO:0004936 alpha-adrenergic receptor activity(GO:0004936) epinephrine binding(GO:0051379)
2.1 6.2 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.2 6.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 6.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 5.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.4 5.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.3 5.3 GO:0004096 catalase activity(GO:0004096)
0.2 5.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 5.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.4 5.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 5.0 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 5.0 GO:0008289 lipid binding(GO:0008289)
0.8 4.9 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 31.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.3 12.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 11.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 8.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 4.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.3 4.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 4.1 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 3.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 3.2 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.1 3.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.0 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 3.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 2.9 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 2.8 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 2.6 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 2.6 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 2.5 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 2.5 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 2.1 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 1.9 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 40.4 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.8 15.7 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.5 10.8 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.4 10.7 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.3 10.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 9.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 5.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 5.4 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 5.4 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 5.3 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.2 5.0 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.3 4.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.3 4.8 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.3 4.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.2 4.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.3 4.1 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.2 4.1 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 3.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 3.6 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 3.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation