Motif ID: Gfi1_Gfi1b

Z-value: 1.321

Transcription factors associated with Gfi1_Gfi1b:

Gene SymbolEntrez IDGene Name
Gfi1 ENSMUSG00000029275.11 Gfi1
Gfi1b ENSMUSG00000026815.8 Gfi1b



Activity profile for motif Gfi1_Gfi1b.

activity profile for motif Gfi1_Gfi1b


Sorted Z-values histogram for motif Gfi1_Gfi1b

Sorted Z-values for motif Gfi1_Gfi1b



Network of associatons between targets according to the STRING database.



First level regulatory network of Gfi1_Gfi1b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 22.089 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr16_-_26989974 13.699 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr7_+_62376979 10.351 ENSMUST00000080403.5
 Magel2
melanoma antigen, family L, 2
chr7_-_17062384 6.605 ENSMUST00000153833.1
ENSMUST00000108492.2
 Hif3a

hypoxia inducible factor 3, alpha subunit

chr10_+_13090788 6.466 ENSMUST00000121646.1
ENSMUST00000121325.1
ENSMUST00000121766.1
 Plagl1


pleiomorphic adenoma gene-like 1


chr13_+_35659856 6.343 ENSMUST00000075220.6
 Cdyl
chromodomain protein, Y chromosome-like
chr9_+_3027439 6.209 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr7_-_62464505 6.187 ENSMUST00000094339.2
 Peg12
paternally expressed 12
chr9_+_3005125 5.911 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3000922 5.827 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_-_70421533 5.711 ENSMUST00000034742.6
 Ccnb2
cyclin B2
chr9_+_3034599 5.413 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3013140 5.370 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr18_+_50030977 5.351 ENSMUST00000145726.1
ENSMUST00000128377.1
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr11_+_112782182 4.980 ENSMUST00000000579.2
 Sox9
SRY-box containing gene 9
chr17_-_70849644 4.882 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr9_+_3023547 4.864 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr8_-_61591130 4.777 ENSMUST00000135439.1
ENSMUST00000121200.1
 Palld

palladin, cytoskeletal associated protein

chr9_+_3017408 4.723 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr5_+_75075464 4.687 ENSMUST00000160104.1
ENSMUST00000040477.3
 Gsx2

GS homeobox 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 210 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 22.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 16.0 GO:0006270 DNA replication initiation(GO:0006270)
0.7 10.3 GO:0051127 positive regulation of actin nucleation(GO:0051127)
1.8 7.1 GO:2000768 positive regulation of epithelial cell differentiation involved in kidney development(GO:2000698) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.1 6.5 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.2 6.2 GO:0000578 embryonic axis specification(GO:0000578)
0.1 6.0 GO:0043029 T cell homeostasis(GO:0043029)
0.2 5.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 5.2 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
1.7 5.0 GO:0035622 intrahepatic bile duct development(GO:0035622) renal vesicle induction(GO:0072034)
0.3 4.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 4.8 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.3 4.8 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.2 4.6 GO:0008340 determination of adult lifespan(GO:0008340)
2.2 4.5 GO:1990705 cholangiocyte proliferation(GO:1990705)
0.0 4.4 GO:0001525 angiogenesis(GO:0001525)
0.4 4.1 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.2 4.1 GO:0030903 notochord development(GO:0030903)
1.3 4.0 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
1.3 3.8 GO:0014826 vein smooth muscle contraction(GO:0014826)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.3 GO:0016607 nuclear speck(GO:0016607)
0.1 14.4 GO:0000775 chromosome, centromeric region(GO:0000775)
0.3 10.4 GO:0030904 retromer complex(GO:0030904)
0.0 5.5 GO:0016604 nuclear body(GO:0016604)
0.1 5.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 4.8 GO:0002102 podosome(GO:0002102)
0.2 4.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 3.8 GO:0045120 pronucleus(GO:0045120)
0.1 3.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.4 3.0 GO:0033269 internode region of axon(GO:0033269)
1.0 2.9 GO:0071914 prominosome(GO:0071914)
0.0 2.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.4 2.8 GO:0008278 cohesin complex(GO:0008278)
0.1 2.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 2.8 GO:0043209 myelin sheath(GO:0043209)
0.4 2.7 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 2.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.3 2.3 GO:0001520 outer dense fiber(GO:0001520) meiotic spindle(GO:0072687)
0.0 2.3 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 2.2 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 24.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 11.8 GO:0003682 chromatin binding(GO:0003682)
0.0 10.8 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 9.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.2 8.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 7.0 GO:0045296 cadherin binding(GO:0045296)
0.1 6.4 GO:0035064 methylated histone binding(GO:0035064)
0.6 6.1 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.0 5.5 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.2 5.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 5.3 GO:0035326 enhancer binding(GO:0035326)
0.1 5.3 GO:0051082 unfolded protein binding(GO:0051082)
0.0 5.3 GO:0003779 actin binding(GO:0003779)
0.2 4.9 GO:0070410 co-SMAD binding(GO:0070410)
0.0 4.5 GO:0003714 transcription corepressor activity(GO:0003714)
1.3 4.0 GO:0016015 morphogen activity(GO:0016015)
0.0 3.9 GO:0051015 actin filament binding(GO:0051015)
1.3 3.8 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 3.8 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 3.7 GO:0042393 histone binding(GO:0042393)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 6.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 6.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.3 5.8 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.4 5.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 4.9 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 3.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 2.2 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.2 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 1.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.4 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 1.4 ST_INTEGRIN_SIGNALING_PATHWAY Integrin Signaling Pathway
0.3 1.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.1 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 1.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 1.0 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.4 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 6.6 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 6.5 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.3 5.9 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 4.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 4.1 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 4.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 4.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 3.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.4 3.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 3.0 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 2.9 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 2.9 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 2.9 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 2.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 2.6 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 2.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.4 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 2.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi