Motif ID: Gli1

Z-value: 0.688


Transcription factors associated with Gli1:

Gene SymbolEntrez IDGene Name
Gli1 ENSMUSG00000025407.6 Gli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli1mm10_v2_chr10_-_127341583_127341614-0.452.9e-03Click!


Activity profile for motif Gli1.

activity profile for motif Gli1


Sorted Z-values histogram for motif Gli1

Sorted Z-values for motif Gli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli1

PNG image of the network

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Top targets:


Showing 1 to 20 of 181 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_78544345 2.498 ENSMUST00000053239.2
 Sstr3
somatostatin receptor 3
chr11_-_119547744 2.321 ENSMUST00000026670.4
 Nptx1
neuronal pentraxin 1
chr2_-_54085542 2.286 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr13_-_114458720 1.914 ENSMUST00000022287.5
 Fst
follistatin
chr14_+_25607797 1.907 ENSMUST00000160229.1
 Zmiz1
zinc finger, MIZ-type containing 1
chr11_+_80300866 1.878 ENSMUST00000017836.7
 Rhbdl3
rhomboid, veinlet-like 3 (Drosophila)
chr15_-_85581809 1.790 ENSMUST00000023015.7
 Wnt7b
wingless-related MMTV integration site 7B
chr18_-_43373248 1.564 ENSMUST00000118043.1
 Dpysl3
dihydropyrimidinase-like 3
chr15_-_95528228 1.559 ENSMUST00000075275.2
 Nell2
NEL-like 2
chr6_-_52012476 1.477 ENSMUST00000078214.5
 Skap2
src family associated phosphoprotein 2
chr10_-_64090265 1.434 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr8_+_45658273 1.421 ENSMUST00000153798.1
 Sorbs2
sorbin and SH3 domain containing 2
chr10_-_64090241 1.419 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr1_-_133801031 1.377 ENSMUST00000143567.1
 Atp2b4
ATPase, Ca++ transporting, plasma membrane 4
chr12_+_44328882 1.317 ENSMUST00000020939.8
ENSMUST00000110748.2
 Nrcam

neuron-glia-CAM-related cell adhesion molecule

chr9_+_50752758 1.291 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr12_-_81333129 1.230 ENSMUST00000085238.6
ENSMUST00000182208.1
 Slc8a3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr15_-_95528702 1.228 ENSMUST00000166170.1
 Nell2
NEL-like 2
chr1_-_64121389 1.202 ENSMUST00000055001.3
 Klf7
Kruppel-like factor 7 (ubiquitous)
chrX_+_159303266 1.179 ENSMUST00000112491.1
 Rps6ka3
ribosomal protein S6 kinase polypeptide 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 3.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 2.9 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.3 2.8 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 2.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.5 2.3 GO:0035864 response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.0 2.3 GO:0007050 cell cycle arrest(GO:0007050)
0.1 2.0 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.3 1.9 GO:0007296 vitellogenesis(GO:0007296)
0.2 1.9 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.6 1.8 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.3 1.8 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.6 1.7 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.1 1.6 GO:0051764 actin crosslink formation(GO:0051764)
0.4 1.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 1.4 GO:0007520 myoblast fusion(GO:0007520)
0.2 1.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.2 1.3 GO:0007021 tubulin complex assembly(GO:0007021)
0.4 1.2 GO:2000331 regulation of terminal button organization(GO:2000331)
0.0 1.2 GO:1902017 regulation of cilium assembly(GO:1902017)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 2.9 GO:0043204 perikaryon(GO:0043204)
0.0 2.7 GO:0030139 endocytic vesicle(GO:0030139)
0.1 2.6 GO:0060170 ciliary membrane(GO:0060170)
0.0 2.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 2.2 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 1.6 GO:0031941 filamentous actin(GO:0031941)
0.1 1.4 GO:0097228 sperm principal piece(GO:0097228)
0.2 1.3 GO:0097512 cardiac myofibril(GO:0097512)
0.1 1.3 GO:0043194 axon initial segment(GO:0043194)
0.0 1.2 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.1 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.0 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.8 GO:0043195 terminal bouton(GO:0043195)
0.0 0.7 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.6 GO:0042825 TAP complex(GO:0042825)
0.0 0.6 GO:0030132 clathrin coat of coated pit(GO:0030132)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 2.8 GO:0005080 protein kinase C binding(GO:0005080)
0.8 2.5 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 2.1 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.2 1.9 GO:0048185 activin binding(GO:0048185)
0.0 1.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.4 1.8 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.0 1.8 GO:0005262 calcium channel activity(GO:0005262)
0.2 1.6 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.2 1.5 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 1.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 1.3 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 1.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 1.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 1.0 GO:0048487 beta-tubulin binding(GO:0048487)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.8 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.7 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.5 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.5 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.6 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.6 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.6 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 4.0 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 2.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.6 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.6 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 1.5 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.2 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 1.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.8 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.7 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 0.6 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.6 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.6 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.6 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.4 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.4 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.4 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.4 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)