Motif ID: Gli2

Z-value: 0.790


Transcription factors associated with Gli2:

Gene SymbolEntrez IDGene Name
Gli2 ENSMUSG00000048402.8 Gli2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli2mm10_v2_chr1_-_119053619_1190536380.182.5e-01Click!


Activity profile for motif Gli2.

activity profile for motif Gli2


Sorted Z-values histogram for motif Gli2

Sorted Z-values for motif Gli2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli2

PNG image of the network

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Top targets:


Showing 1 to 20 of 140 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 7.659 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr15_-_56694525 5.856 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr6_-_72789240 5.834 ENSMUST00000069536.5
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr6_-_72788952 5.327 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chrX_-_141725181 5.294 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr7_-_137314394 3.730 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr12_+_58211772 3.340 ENSMUST00000110671.2
ENSMUST00000044299.2
 Sstr1

somatostatin receptor 1

chr7_-_4752972 3.321 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr12_+_38780284 2.898 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr9_-_43239816 2.860 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr8_+_127064022 2.403 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
 Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr4_+_36952930 2.349 ENSMUST00000144029.1
 Gm12371
predicted gene 12371
chrX_-_9662950 2.293 ENSMUST00000033519.2
 Dynlt3
dynein light chain Tctex-type 3
chr5_-_24527276 2.221 ENSMUST00000088311.4
 Gbx1
gastrulation brain homeobox 1
chr8_+_127064107 2.166 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
 Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr8_+_127063893 2.047 ENSMUST00000162309.1
 Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr13_+_5861489 1.714 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr16_-_88056176 1.691 ENSMUST00000072256.5
ENSMUST00000023652.8
ENSMUST00000114137.1
 Grik1


glutamate receptor, ionotropic, kainate 1


chr15_-_85581809 1.676 ENSMUST00000023015.7
 Wnt7b
wingless-related MMTV integration site 7B
chr18_+_86394952 1.622 ENSMUST00000058829.2
 Neto1
neuropilin (NRP) and tolloid (TLL)-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 11.2 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
1.3 7.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.1 6.6 GO:0003383 apical constriction(GO:0003383)
1.5 5.9 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 4.0 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.3 3.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.2 3.3 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.3 2.9 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 2.7 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 2.3 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.6 2.2 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.3 2.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.4 1.8 GO:0015705 iodide transport(GO:0015705)
0.6 1.7 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.3 1.7 GO:0032229 negative regulation of synaptic transmission, GABAergic(GO:0032229)
0.5 1.6 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.3 1.6 GO:0045218 zonula adherens maintenance(GO:0045218)
0.3 1.6 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.2 1.5 GO:0001842 neural fold formation(GO:0001842)
0.0 1.5 GO:0043171 peptide catabolic process(GO:0043171)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.7 GO:0005667 transcription factor complex(GO:0005667)
0.8 6.6 GO:0033269 internode region of axon(GO:0033269)
0.1 5.0 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 3.3 GO:0030061 mitochondrial crista(GO:0030061)
0.2 3.3 GO:0097470 ribbon synapse(GO:0097470)
0.5 2.3 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 2.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.3 1.7 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 1.7 GO:0001650 fibrillar center(GO:0001650)
0.1 1.6 GO:0005915 zonula adherens(GO:0005915)
0.1 1.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 1.6 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.4 1.5 GO:0090537 CERF complex(GO:0090537)
0.0 1.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 1.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.2 1.0 GO:0070876 SOSS complex(GO:0070876)
0.0 1.0 GO:0033270 paranode region of axon(GO:0033270)
0.1 0.9 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.9 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.8 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.2 GO:0008013 beta-catenin binding(GO:0008013)
0.2 8.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 7.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 5.4 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
1.6 4.7 GO:0050501 hyaluronan synthase activity(GO:0050501)
1.1 3.3 GO:0004994 somatostatin receptor activity(GO:0004994)
0.4 3.3 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1 2.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.5 2.2 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 2.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 2.0 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.5 1.8 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.4 1.7 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.3 1.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 1.7 GO:0003774 motor activity(GO:0003774)
0.1 1.6 GO:0070097 delta-catenin binding(GO:0070097)
0.0 1.6 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 1.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.4 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 1.4 GO:0004402 histone acetyltransferase activity(GO:0004402)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.9 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.2 8.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 3.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 2.3 NABA_COLLAGENS Genes encoding collagen proteins
0.1 2.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.0 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 4.7 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 3.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 2.2 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.0 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.7 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.0 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 1.0 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 0.9 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.8 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.7 REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ Genes involved in Cleavage of Growing Transcript in the Termination Region
0.0 0.6 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 0.5 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.5 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 0.4 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.2 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade