Motif ID: Gli3_Zic1

Z-value: 1.129

Transcription factors associated with Gli3_Zic1:

Gene SymbolEntrez IDGene Name
Gli3 ENSMUSG00000021318.9 Gli3
Zic1 ENSMUSG00000032368.8 Zic1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli3mm10_v2_chr13_+_15463837_15463980-0.654.6e-06Click!
Zic1mm10_v2_chr9_-_91365756_913657740.076.8e-01Click!


Activity profile for motif Gli3_Zic1.

activity profile for motif Gli3_Zic1


Sorted Z-values histogram for motif Gli3_Zic1

Sorted Z-values for motif Gli3_Zic1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli3_Zic1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_101377897 7.463 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr9_+_50752758 5.820 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr1_-_133801031 4.749 ENSMUST00000143567.1
 Atp2b4
ATPase, Ca++ transporting, plasma membrane 4
chr2_-_29253001 4.430 ENSMUST00000071201.4
 Ntng2
netrin G2
chr11_-_116654245 4.418 ENSMUST00000021166.5
 Cygb
cytoglobin
chr4_+_124657646 4.228 ENSMUST00000053491.7
 Pou3f1
POU domain, class 3, transcription factor 1
chr6_+_17463749 4.216 ENSMUST00000115443.1
 Met
met proto-oncogene
chrX_-_16911774 4.094 ENSMUST00000040134.7
 Ndp
Norrie disease (pseudoglioma) (human)
chr7_+_99268338 4.081 ENSMUST00000107100.2
 Map6
microtubule-associated protein 6
chr11_-_42000284 3.999 ENSMUST00000109292.2
ENSMUST00000109290.1
 Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr11_-_42000532 3.790 ENSMUST00000070735.3
 Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr8_-_105966038 3.764 ENSMUST00000116429.2
ENSMUST00000034370.9
 Slc12a4

solute carrier family 12, member 4

chr16_+_91269759 3.647 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr17_-_24209377 3.593 ENSMUST00000024931.4
 Ntn3
netrin 3
chr4_-_136956784 3.546 ENSMUST00000030420.8
 Epha8
Eph receptor A8
chr4_-_148130678 3.460 ENSMUST00000030862.4
 Draxin
dorsal inhibitory axon guidance protein
chr4_+_48045144 3.449 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr8_+_70501116 3.438 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr4_+_144893077 3.150 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr6_-_113531575 3.112 ENSMUST00000032425.5
 Emc3
ER membrane protein complex subunit 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 210 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 11.5 GO:0071420 cellular response to histamine(GO:0071420)
1.2 8.4 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 8.0 GO:0007528 neuromuscular junction development(GO:0007528)
2.3 6.8 GO:1904978 regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980)
1.0 5.8 GO:0007021 tubulin complex assembly(GO:0007021)
0.5 5.1 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 4.9 GO:0036465 synaptic vesicle recycling(GO:0036465)
1.6 4.7 GO:0045763 regulation of arginine metabolic process(GO:0000821) negative regulation of cellular amino acid metabolic process(GO:0045763)
0.9 4.4 GO:0015671 oxygen transport(GO:0015671)
0.3 4.2 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
1.0 4.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 4.1 GO:0032418 lysosome localization(GO:0032418)
0.0 4.1 GO:0006813 potassium ion transport(GO:0006813)
0.2 3.8 GO:0001553 luteinization(GO:0001553)
0.5 3.7 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.1 3.6 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.1 3.6 GO:0007520 myoblast fusion(GO:0007520)
0.4 3.5 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.2 3.5 GO:0021516 dorsal spinal cord development(GO:0021516)
1.1 3.4 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 11.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.3 9.8 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.1 8.5 GO:0031594 neuromuscular junction(GO:0031594)
0.1 8.2 GO:0009925 basal plasma membrane(GO:0009925)
0.2 7.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.3 6.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
1.0 5.7 GO:0097512 cardiac myofibril(GO:0097512)
0.5 4.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 4.7 GO:0097228 sperm principal piece(GO:0097228)
0.1 4.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 4.3 GO:0016604 nuclear body(GO:0016604)
0.2 4.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 4.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 4.2 GO:0016607 nuclear speck(GO:0016607)
0.0 4.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2 4.0 GO:0032279 asymmetric synapse(GO:0032279)
0.7 3.7 GO:1902710 GABA receptor complex(GO:1902710)
1.1 3.4 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 3.3 GO:0032587 ruffle membrane(GO:0032587)
0.0 3.3 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 11.5 GO:0004890 GABA-A receptor activity(GO:0004890)
2.1 8.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
1.4 6.8 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.0 6.8 GO:0005516 calmodulin binding(GO:0005516)
0.0 6.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.3 5.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 5.5 GO:0032452 histone demethylase activity(GO:0032452)
0.1 5.1 GO:0030507 spectrin binding(GO:0030507)
0.6 4.9 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
1.1 4.4 GO:0004096 catalase activity(GO:0004096)
0.0 4.3 GO:0005125 cytokine activity(GO:0005125)
0.0 4.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 4.0 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 4.0 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.1 4.0 GO:0030276 clathrin binding(GO:0030276)
0.0 4.0 GO:0017124 SH3 domain binding(GO:0017124)
0.1 3.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.5 3.8 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.6 3.7 GO:0016917 GABA receptor activity(GO:0016917)
0.0 3.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.2 PID_ARF6_PATHWAY Arf6 signaling events
0.2 10.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 5.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 5.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 3.8 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 3.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 3.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.1 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 2.9 PID_ARF_3PATHWAY Arf1 pathway
0.2 2.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 2.5 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 2.4 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 2.3 ST_STAT3_PATHWAY STAT3 Pathway
0.0 2.2 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 2.2 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 1.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.7 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.7 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 1.6 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 11.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 7.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 7.1 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 6.8 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.4 5.1 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 4.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 3.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 3.2 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 3.0 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 3.0 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 2.7 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 2.7 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.2 2.6 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 2.5 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 2.2 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 1.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.4 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 1.4 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels