Motif ID: Glis2

Z-value: 1.027


Transcription factors associated with Glis2:

Gene SymbolEntrez IDGene Name
Glis2 ENSMUSG00000014303.7 Glis2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis2mm10_v2_chr16_+_4594683_4594735-0.314.8e-02Click!


Activity profile for motif Glis2.

activity profile for motif Glis2


Sorted Z-values histogram for motif Glis2

Sorted Z-values for motif Glis2



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis2

PNG image of the network

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Top targets:


Showing 1 to 20 of 170 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 15.167 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr2_-_54085542 5.267 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr4_-_58499398 5.208 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr7_-_103843154 4.508 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr6_-_48840988 4.256 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B
chr12_+_109544498 3.994 ENSMUST00000126289.1
 Meg3
maternally expressed 3
chr5_+_136083916 3.986 ENSMUST00000042135.7
 Rasa4
RAS p21 protein activator 4
chr4_+_109978004 3.932 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr2_-_57124003 3.922 ENSMUST00000112629.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr5_+_136084022 3.891 ENSMUST00000100570.3
 Rasa4
RAS p21 protein activator 4
chr6_+_48841476 3.875 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr6_+_48841633 3.873 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr1_-_84696182 3.672 ENSMUST00000049126.6
 Dner
delta/notch-like EGF-related receptor
chr8_-_87472576 3.624 ENSMUST00000034076.8
 Cbln1
cerebellin 1 precursor protein
chr2_+_174330006 3.482 ENSMUST00000109085.1
ENSMUST00000109087.1
ENSMUST00000109084.1
 Gnas


GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus


chr8_+_58911755 3.481 ENSMUST00000062978.6
 BC030500
cDNA sequence BC030500
chr3_-_89322883 3.324 ENSMUST00000029673.5
 Efna3
ephrin A3
chr2_-_57113053 3.245 ENSMUST00000112627.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr17_-_56830916 3.175 ENSMUST00000002444.7
ENSMUST00000086801.5
 Rfx2

regulatory factor X, 2 (influences HLA class II expression)

chr6_-_48841098 3.055 ENSMUST00000101429.4
 Tmem176b
transmembrane protein 176B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 18.1 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
1.2 15.2 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.2 7.9 GO:0034260 negative regulation of GTPase activity(GO:0034260)
1.8 7.2 GO:0051866 general adaptation syndrome(GO:0051866)
1.3 5.2 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 5.1 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 5.1 GO:0007050 cell cycle arrest(GO:0007050)
1.6 4.9 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.5 4.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.9 4.5 GO:0015671 oxygen transport(GO:0015671)
0.8 3.8 GO:1905247 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.2 3.7 GO:0007220 Notch receptor processing(GO:0007220)
0.6 3.6 GO:0032796 uropod organization(GO:0032796)
0.4 3.6 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.3 3.6 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.7 3.5 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.2 3.2 GO:0001675 acrosome assembly(GO:0001675)
0.1 3.0 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
1.0 2.9 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.2 2.8 GO:0021796 cerebral cortex regionalization(GO:0021796)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 7.9 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 7.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 7.1 GO:0016607 nuclear speck(GO:0016607)
0.0 5.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 5.2 GO:0043198 dendritic shaft(GO:0043198)
0.1 5.1 GO:0005882 intermediate filament(GO:0005882)
0.3 4.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.6 4.5 GO:0005833 hemoglobin complex(GO:0005833)
0.0 4.1 GO:0005769 early endosome(GO:0005769)
0.3 3.6 GO:0032426 stereocilium tip(GO:0032426)
0.4 3.4 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 3.0 GO:0016235 aggresome(GO:0016235)
0.0 2.6 GO:0009986 cell surface(GO:0009986)
0.2 2.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 2.3 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.4 2.2 GO:0097443 sorting endosome(GO:0097443)
0.1 2.2 GO:0034451 centriolar satellite(GO:0034451)
0.7 2.1 GO:0005577 fibrinogen complex(GO:0005577)
0.7 2.0 GO:0044194 cytolytic granule(GO:0044194)
0.5 2.0 GO:0090537 CERF complex(GO:0090537)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 15.2 GO:0019841 retinol binding(GO:0019841)
0.2 7.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 5.3 GO:0005096 GTPase activator activity(GO:0005096)
0.7 5.2 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.6 5.1 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
1.6 4.9 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.8 4.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.1 4.5 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 3.8 GO:0005112 Notch binding(GO:0005112)
0.3 3.6 GO:0032036 myosin heavy chain binding(GO:0032036)
0.6 3.5 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.5 3.4 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 3.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 3.0 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 2.9 GO:0008009 chemokine activity(GO:0008009)
0.1 2.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.7 2.6 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.5 2.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 2.6 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 2.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 4.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.5 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 3.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 3.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 3.6 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 3.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 2.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.4 PID_EPO_PATHWAY EPO signaling pathway
0.1 2.1 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 1.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.7 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.6 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.5 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.4 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.0 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 0.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.9 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.4 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1 7.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 6.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 5.2 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 4.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.7 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 3.0 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.2 2.6 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.2 2.6 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 2.2 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 2.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 2.0 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.7 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 1.5 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.2 1.4 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.4 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.4 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex