Motif ID: Glis3

Z-value: 0.581


Transcription factors associated with Glis3:

Gene SymbolEntrez IDGene Name
Glis3 ENSMUSG00000052942.7 Glis3
Glis3 ENSMUSG00000091294.1 Glis3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis3mm10_v2_chr19_-_28680077_286801220.143.8e-01Click!


Activity profile for motif Glis3.

activity profile for motif Glis3


Sorted Z-values histogram for motif Glis3

Sorted Z-values for motif Glis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis3

PNG image of the network

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Top targets:


Showing 1 to 20 of 133 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144893077 1.918 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144892813 1.898 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_+_144893127 1.862 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr6_+_17463749 1.393 ENSMUST00000115443.1
 Met
met proto-oncogene
chr7_-_142657466 1.148 ENSMUST00000097936.2
ENSMUST00000000033.5
 Igf2

insulin-like growth factor 2

chr6_+_17463826 1.027 ENSMUST00000140070.1
 Met
met proto-oncogene
chr6_+_17463927 0.954 ENSMUST00000115442.1
 Met
met proto-oncogene
chr7_-_49636847 0.894 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr13_-_40730416 0.850 ENSMUST00000021787.5
 Tfap2a
transcription factor AP-2, alpha
chr7_-_142899985 0.832 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chr11_+_101468164 0.829 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr4_-_134018829 0.757 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chrM_+_9452 0.702 ENSMUST00000082411.1
 mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr11_-_102296618 0.680 ENSMUST00000107132.2
ENSMUST00000073234.2
 Atxn7l3

ataxin 7-like 3

chr14_+_54640952 0.625 ENSMUST00000169818.2
 Gm17606
predicted gene, 17606
chr13_+_44730726 0.621 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
 Jarid2


jumonji, AT rich interactive domain 2


chr10_-_105574435 0.564 ENSMUST00000061506.8
 Tmtc2
transmembrane and tetratricopeptide repeat containing 2
chr13_+_38345716 0.562 ENSMUST00000171970.1
 Bmp6
bone morphogenetic protein 6
chr4_+_118428078 0.555 ENSMUST00000006557.6
ENSMUST00000167636.1
ENSMUST00000102673.4
 Elovl1


elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1


chr10_+_61175206 0.526 ENSMUST00000079235.5
 Tbata
thymus, brain and testes associated

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.7 GO:0042572 retinol metabolic process(GO:0042572)
0.5 3.4 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 1.1 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.3 0.9 GO:0070172 oculomotor nerve development(GO:0021557) positive regulation of tooth mineralization(GO:0070172)
0.0 0.9 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.2 0.8 GO:0042414 epinephrine metabolic process(GO:0042414)
0.1 0.8 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.7 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.7 GO:0071384 cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.2 0.6 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1 0.6 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 0.6 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.1 0.6 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.6 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.6 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.6 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.1 0.5 GO:0070814 hydrogen sulfide biosynthetic process(GO:0070814)
0.1 0.5 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.1 0.5 GO:0060613 fat pad development(GO:0060613)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.3 0.8 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.7 GO:0000124 SAGA complex(GO:0000124)
0.0 0.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.6 GO:0016605 PML body(GO:0016605)
0.1 0.4 GO:0033503 HULC complex(GO:0033503)
0.1 0.4 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.3 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.2 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0031084 BLOC-2 complex(GO:0031084)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.8 3.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 1.1 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 0.8 GO:0035240 dopamine binding(GO:0035240)
0.1 0.8 GO:0008494 translation activator activity(GO:0008494)
0.1 0.8 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 0.8 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.7 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 0.6 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.6 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 0.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.6 GO:0031386 protein tag(GO:0031386)
0.1 0.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.4 GO:0045545 syndecan binding(GO:0045545)
0.1 0.4 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 3.3 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.7 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.1 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.0 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.2 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 1.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.8 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.8 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.6 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.6 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.5 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.5 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions