Motif ID: Gsc2_Dmbx1

Z-value: 0.759

Transcription factors associated with Gsc2_Dmbx1:

Gene SymbolEntrez IDGene Name
Dmbx1 ENSMUSG00000028707.9 Dmbx1
Gsc2 ENSMUSG00000022738.6 Gsc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmbx1mm10_v2_chr4_-_115939923_1159399280.534.2e-04Click!


Activity profile for motif Gsc2_Dmbx1.

activity profile for motif Gsc2_Dmbx1


Sorted Z-values histogram for motif Gsc2_Dmbx1

Sorted Z-values for motif Gsc2_Dmbx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsc2_Dmbx1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 91 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_137766474 10.809 ENSMUST00000139951.1
 Alpl
alkaline phosphatase, liver/bone/kidney
chr14_-_118052235 8.819 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr4_+_154960915 7.410 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr2_+_91259822 5.739 ENSMUST00000138470.1
 Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr11_+_78322965 5.201 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr5_+_3344194 4.874 ENSMUST00000042410.4
 Cdk6
cyclin-dependent kinase 6
chr5_+_3343893 4.687 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr11_-_52282564 4.048 ENSMUST00000086844.3
 Tcf7
transcription factor 7, T cell specific
chr13_-_116309639 3.249 ENSMUST00000036060.6
 Isl1
ISL1 transcription factor, LIM/homeodomain
chr11_-_68973840 2.818 ENSMUST00000038644.4
 Rangrf
RAN guanine nucleotide release factor
chr17_-_58991343 2.422 ENSMUST00000025064.7
 2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr17_+_35861318 2.289 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr4_-_141053660 2.211 ENSMUST00000040222.7
 Crocc
ciliary rootlet coiled-coil, rootletin
chr5_+_77265454 2.081 ENSMUST00000080359.5
 Rest
RE1-silencing transcription factor
chr17_+_35861343 2.023 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr14_-_31640878 1.933 ENSMUST00000167066.1
ENSMUST00000127204.2
ENSMUST00000022437.8
 Hacl1


2-hydroxyacyl-CoA lyase 1


chr2_+_164562579 1.912 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr14_+_99298652 1.801 ENSMUST00000005279.6
 Klf5
Kruppel-like factor 5
chr3_-_103737995 1.735 ENSMUST00000029440.8
 Olfml3
olfactomedin-like 3
chr13_+_3361029 1.707 ENSMUST00000179981.1
 Gm16505
predicted gene 16505

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.8 GO:0046677 response to antibiotic(GO:0046677)
1.4 9.6 GO:0044838 cell quiescence(GO:0044838)
1.5 8.8 GO:0006570 tyrosine metabolic process(GO:0006570)
1.9 7.4 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.2 5.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.5 5.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.5 4.0 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
1.1 3.2 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.1 3.2 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.8 3.0 GO:0032053 ciliary basal body organization(GO:0032053)
0.1 3.0 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.0 2.9 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.5 2.8 GO:0086028 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043)
0.0 2.7 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.5 2.1 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.4 1.9 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 1.9 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.3 1.8 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 1.7 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.1 1.3 GO:0090331 negative regulation of platelet aggregation(GO:0090331)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.6 10.8 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.3 8.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 4.3 GO:0005652 nuclear lamina(GO:0005652)
0.1 4.0 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 3.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 3.0 GO:0035253 ciliary rootlet(GO:0035253)
0.1 3.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 2.8 GO:0014704 intercalated disc(GO:0014704)
0.0 2.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 0.8 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 0.5 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.3 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
2.7 10.8 GO:0004035 alkaline phosphatase activity(GO:0004035)
3.2 9.6 GO:0098770 FBXO family protein binding(GO:0098770)
0.7 8.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.4 5.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.9 5.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 5.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 3.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 3.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin binding(GO:0030332)
0.1 3.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 2.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 2.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.4 1.9 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.2 1.9 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 1.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 1.3 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 1.3 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.2 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 1.2 GO:0019894 kinesin binding(GO:0019894)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 7.4 PID_CDC42_PATHWAY CDC42 signaling events
0.0 3.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.7 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 7.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 5.2 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 4.0 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.2 3.4 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 3.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 1.9 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.2 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins