Motif ID: Gsx1_Alx1_Mixl1_Lbx2

Z-value: 0.546

Transcription factors associated with Gsx1_Alx1_Mixl1_Lbx2:

Gene SymbolEntrez IDGene Name
Alx1 ENSMUSG00000036602.7 Alx1
Gsx1 ENSMUSG00000053129.5 Gsx1
Lbx2 ENSMUSG00000034968.2 Lbx2
Mixl1 ENSMUSG00000026497.7 Mixl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gsx1mm10_v2_chr5_+_147188678_147188696-0.305.6e-02Click!
Alx1mm10_v2_chr10_-_103028771_1030287820.241.3e-01Click!


Activity profile for motif Gsx1_Alx1_Mixl1_Lbx2.

activity profile for motif Gsx1_Alx1_Mixl1_Lbx2


Sorted Z-values histogram for motif Gsx1_Alx1_Mixl1_Lbx2

Sorted Z-values for motif Gsx1_Alx1_Mixl1_Lbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx1_Alx1_Mixl1_Lbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_62766153 6.922 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_-_49757257 5.018 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr13_+_44121167 3.388 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr2_+_116067213 3.151 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr7_+_103550368 3.001 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chr5_-_62765618 2.455 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr18_+_57468478 2.325 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr1_-_190170671 2.273 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr2_-_116067391 2.208 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr1_-_163725123 2.116 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr5_-_84417359 2.038 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr11_-_98053415 2.036 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chrX_+_56454871 1.857 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr3_+_62419668 1.786 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chrM_+_7005 1.578 ENSMUST00000082405.1
 mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr5_+_17574726 1.429 ENSMUST00000169603.1
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr15_-_11037968 1.340 ENSMUST00000058007.5
 Rxfp3
relaxin family peptide receptor 3
chr15_+_55307743 1.304 ENSMUST00000023053.5
ENSMUST00000110221.2
ENSMUST00000110217.3
 Col14a1


collagen, type XIV, alpha 1


chr17_+_45734506 1.255 ENSMUST00000180558.1
 F630040K05Rik
RIKEN cDNA F630040K05 gene
chr15_+_18818895 1.230 ENSMUST00000166873.2
 Cdh10
cadherin 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 3.6 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.5 3.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 2.6 GO:0007608 sensory perception of smell(GO:0007608)
0.8 2.3 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.2 2.2 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 2.1 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 1.8 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 1.7 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.3 1.6 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 1.4 GO:0061050 regulation of cell growth involved in cardiac muscle cell development(GO:0061050)
0.3 1.3 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 1.3 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 1.2 GO:0030497 fatty acid elongation(GO:0030497)
0.1 1.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 1.0 GO:0060178 regulation of exocyst localization(GO:0060178)
0.1 1.0 GO:0015824 proline transport(GO:0015824)
0.1 1.0 GO:0046548 retinal rod cell development(GO:0046548)
0.1 0.9 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.9 GO:0033194 response to hydroperoxide(GO:0033194)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 GO:0070469 respiratory chain(GO:0070469)
0.2 2.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 1.0 GO:0051286 cell tip(GO:0051286)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.3 0.8 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 0.8 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.8 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.8 GO:0030673 axolemma(GO:0030673)
0.0 0.8 GO:0072562 blood microparticle(GO:0072562)
0.2 0.6 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.6 GO:0042581 specific granule(GO:0042581)
0.0 0.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.6 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.6 GO:0016235 aggresome(GO:0016235)
0.1 0.5 GO:0097487 vesicle lumen(GO:0031983) multivesicular body, internal vesicle(GO:0097487)
0.0 0.5 GO:0016272 prefoldin complex(GO:0016272)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 5.9 GO:0005509 calcium ion binding(GO:0005509)
0.3 3.6 GO:0038191 neuropilin binding(GO:0038191)
0.1 3.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 3.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 2.9 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 2.3 GO:0050693 LBD domain binding(GO:0050693)
0.3 2.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 1.9 GO:0008276 protein methyltransferase activity(GO:0008276)
0.3 1.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 1.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.3 1.3 GO:0004966 galanin receptor activity(GO:0004966)
0.4 1.2 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.1 1.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 1.0 GO:0005262 calcium channel activity(GO:0005262)
0.0 1.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.9 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 0.8 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.2 PID_ARF6_PATHWAY Arf6 signaling events
0.0 3.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.4 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.6 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.5 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.5 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.3 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.9 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.1 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.9 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 0.8 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 0.8 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 0.8 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 0.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.6 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.6 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.5 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.5 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.4 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 0.3 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.3 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions