Motif ID: Gtf2i_Gtf2f1

Z-value: 2.397

Transcription factors associated with Gtf2i_Gtf2f1:

Gene SymbolEntrez IDGene Name
Gtf2f1 ENSMUSG00000002658.9 Gtf2f1
Gtf2i ENSMUSG00000060261.9 Gtf2i

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gtf2imm10_v2_chr5_-_134314637_1343146760.654.0e-06Click!
Gtf2f1mm10_v2_chr17_-_57011271_57011326-0.444.5e-03Click!


Activity profile for motif Gtf2i_Gtf2f1.

activity profile for motif Gtf2i_Gtf2f1


Sorted Z-values histogram for motif Gtf2i_Gtf2f1

Sorted Z-values for motif Gtf2i_Gtf2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gtf2i_Gtf2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_78578308 20.370 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr7_+_44310213 16.002 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr15_-_66948419 15.433 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chrX_-_104201126 14.451 ENSMUST00000056502.6
ENSMUST00000118314.1
 C77370

expressed sequence C77370

chr10_-_127620960 14.160 ENSMUST00000121829.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr1_-_56971762 13.836 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr4_-_123527648 13.834 ENSMUST00000147228.1
 Macf1
microtubule-actin crosslinking factor 1
chr16_+_43503607 12.949 ENSMUST00000126100.1
ENSMUST00000123047.1
ENSMUST00000156981.1
 Zbtb20


zinc finger and BTB domain containing 20


chr10_-_127620922 12.010 ENSMUST00000118455.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr15_+_83791939 11.648 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr1_-_64121389 11.475 ENSMUST00000055001.3
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr8_+_107293500 11.459 ENSMUST00000151114.1
ENSMUST00000075922.4
ENSMUST00000125721.1
 Nfat5


nuclear factor of activated T cells 5


chr16_-_74411776 11.439 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr2_-_45112890 11.236 ENSMUST00000076836.6
 Zeb2
zinc finger E-box binding homeobox 2
chr1_-_135585314 10.967 ENSMUST00000040599.8
ENSMUST00000067414.6
 Nav1

neuron navigator 1

chr10_+_13966268 10.885 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr13_+_42709482 10.801 ENSMUST00000066928.5
ENSMUST00000148891.1
 Phactr1

phosphatase and actin regulator 1

chr7_+_96210107 10.717 ENSMUST00000138760.1
 Tenm4
teneurin transmembrane protein 4
chr16_+_44173271 10.587 ENSMUST00000088356.4
ENSMUST00000169582.1
 Gm608

predicted gene 608

chr7_-_78577771 10.478 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 640 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 32.2 GO:0002076 osteoblast development(GO:0002076)
8.0 31.9 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
10.3 30.8 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.5 28.4 GO:0007019 microtubule depolymerization(GO:0007019)
9.0 27.0 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
4.5 26.9 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
2.1 25.7 GO:2000821 regulation of grooming behavior(GO:2000821)
4.3 25.5 GO:0042276 error-prone translesion synthesis(GO:0042276)
2.5 24.8 GO:0046959 habituation(GO:0046959)
0.6 23.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.9 23.1 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.4 22.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.5 21.1 GO:0001919 regulation of receptor recycling(GO:0001919)
1.0 20.9 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.2 18.4 GO:0090630 activation of GTPase activity(GO:0090630)
0.3 16.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.4 15.4 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.5 15.0 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
3.0 14.9 GO:0070327 thyroid hormone transport(GO:0070327)
2.1 14.9 GO:0032811 negative regulation of epinephrine secretion(GO:0032811)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 236 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 119.8 GO:0031224 intrinsic component of membrane(GO:0031224)
0.4 116.5 GO:0014069 postsynaptic density(GO:0014069)
1.5 53.5 GO:0030673 axolemma(GO:0030673)
0.6 51.9 GO:0005905 clathrin-coated pit(GO:0005905)
1.8 47.3 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 26.9 GO:0005768 endosome(GO:0005768)
4.3 25.5 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.2 25.4 GO:0005923 bicellular tight junction(GO:0005923)
0.8 23.8 GO:0043194 axon initial segment(GO:0043194)
0.2 20.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.6 20.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.5 20.2 GO:0042734 presynaptic membrane(GO:0042734)
1.6 19.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
3.6 18.0 GO:0030314 junctional membrane complex(GO:0030314)
1.3 16.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
1.9 16.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
3.3 16.5 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
1.4 15.3 GO:0043083 synaptic cleft(GO:0043083)
0.4 15.1 GO:0035371 microtubule plus-end(GO:0035371)
1.3 14.3 GO:0032584 growth cone membrane(GO:0032584)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 380 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 84.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.4 60.5 GO:0017124 SH3 domain binding(GO:0017124)
0.2 34.9 GO:0008017 microtubule binding(GO:0008017)
10.9 32.7 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
6.2 30.8 GO:0005030 neurotrophin receptor activity(GO:0005030)
3.0 27.0 GO:0008046 axon guidance receptor activity(GO:0008046)
3.5 24.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.2 22.6 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.6 22.0 GO:0070412 R-SMAD binding(GO:0070412)
2.3 18.3 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.6 17.8 GO:0017075 syntaxin-1 binding(GO:0017075)
4.3 17.2 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.9 15.8 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 15.2 GO:0017137 Rab GTPase binding(GO:0017137)
1.6 14.8 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.4 14.7 GO:0043015 gamma-tubulin binding(GO:0043015)
1.8 14.2 GO:0070087 chromo shadow domain binding(GO:0070087)
0.8 13.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 13.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 13.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 35.8 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
1.0 32.6 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.5 25.3 PID_REELIN_PATHWAY Reelin signaling pathway
0.5 22.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.4 18.8 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.3 18.1 PID_LKB1_PATHWAY LKB1 signaling events
0.6 16.6 ST_GA12_PATHWAY G alpha 12 Pathway
0.7 16.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.5 13.6 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.4 13.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.6 12.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.3 12.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.7 11.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.7 11.4 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.3 10.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.6 9.6 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 9.5 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.3 9.3 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 8.2 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.3 8.0 PID_RAS_PATHWAY Regulation of Ras family activation

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 34.9 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.6 26.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 24.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.5 22.1 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
1.3 20.2 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
1.9 18.8 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
1.3 17.0 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.4 13.3 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.4 12.8 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.6 12.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.3 11.9 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 11.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.9 11.0 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.8 10.8 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.4 10.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.7 9.6 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 9.4 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.6 9.0 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.4 8.8 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 8.8 REACTOME_MYOGENESIS Genes involved in Myogenesis