Motif ID: Hcfc1_Six5_Smarcc2_Zfp143

Z-value: 1.912

Transcription factors associated with Hcfc1_Six5_Smarcc2_Zfp143:

Gene SymbolEntrez IDGene Name
Hcfc1 ENSMUSG00000031386.8 Hcfc1
Six5 ENSMUSG00000040841.5 Six5
Smarcc2 ENSMUSG00000025369.8 Smarcc2
Zfp143 ENSMUSG00000061079.7 Zfp143

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp143mm10_v2_chr7_+_110061702_1100617320.391.3e-02Click!
Hcfc1mm10_v2_chrX_-_73966329_739663760.278.6e-02Click!
Smarcc2mm10_v2_chr10_+_128459236_1284592480.278.8e-02Click!
Six5mm10_v2_chr7_+_19094594_19094633-0.251.1e-01Click!


Activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143.

activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143


Sorted Z-values histogram for motif Hcfc1_Six5_Smarcc2_Zfp143

Sorted Z-values for motif Hcfc1_Six5_Smarcc2_Zfp143



Network of associatons between targets according to the STRING database.



First level regulatory network of Hcfc1_Six5_Smarcc2_Zfp143

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_64949632 4.044 ENSMUST00000176832.1
 Hmbox1
homeobox containing 1
chr15_-_43869993 3.565 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr16_-_55934845 3.515 ENSMUST00000121129.1
ENSMUST00000023270.7
 Cep97

centrosomal protein 97

chr16_-_55934797 3.200 ENSMUST00000122280.1
ENSMUST00000121703.2
 Cep97

centrosomal protein 97

chr15_-_53902472 3.140 ENSMUST00000078673.6
 Samd12
sterile alpha motif domain containing 12
chr11_+_101552188 2.775 ENSMUST00000147239.1
 Nbr1
neighbor of Brca1 gene 1
chr9_+_83548309 2.744 ENSMUST00000113215.3
 Sh3bgrl2
SH3 domain binding glutamic acid-rich protein like 2
chr3_+_89520152 2.622 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr7_+_97332311 2.538 ENSMUST00000054107.5
 Kctd21
potassium channel tetramerisation domain containing 21
chr7_+_29768552 2.530 ENSMUST00000032802.4
 Zfp84
zinc finger protein 84
chr1_-_134955847 2.504 ENSMUST00000168381.1
 Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr5_+_24423851 2.465 ENSMUST00000141966.1
 Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr1_-_58973421 2.460 ENSMUST00000173590.1
ENSMUST00000027186.5
 Trak2

trafficking protein, kinesin binding 2

chr14_-_64949838 2.454 ENSMUST00000067843.3
ENSMUST00000176489.1
ENSMUST00000175905.1
ENSMUST00000022544.7
ENSMUST00000175744.1
ENSMUST00000176128.1
 Hmbox1





homeobox containing 1





chr14_+_64652524 2.452 ENSMUST00000100473.4
 Kif13b
kinesin family member 13B
chr4_+_49521176 2.402 ENSMUST00000042964.6
ENSMUST00000107696.1
 Zfp189

zinc finger protein 189

chr11_+_4704642 2.353 ENSMUST00000009220.4
 Zmat5
zinc finger, matrin type 5
chr7_-_29518566 2.313 ENSMUST00000181975.1
 Sipa1l3
signal-induced proliferation-associated 1 like 3
chr6_-_34177048 2.310 ENSMUST00000019143.8
 Slc35b4
solute carrier family 35, member B4
chr7_+_30169861 2.266 ENSMUST00000085668.4
 Gm5113
predicted gene 5113

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 342 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.8 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.4 6.5 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 5.9 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.1 5.0 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 4.6 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.9 4.4 GO:0014886 transition between slow and fast fiber(GO:0014886)
1.0 4.2 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.7 4.0 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
1.2 3.7 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.1 3.7 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 3.7 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.1 2.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.4 2.7 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.3 2.7 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.0 2.6 GO:0015711 organic anion transport(GO:0015711)
0.5 2.5 GO:0051697 protein delipidation(GO:0051697)
0.3 2.5 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.2 2.5 GO:1990403 embryonic brain development(GO:1990403)
0.4 2.4 GO:0009235 cobalamin metabolic process(GO:0009235)
0.6 2.3 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 5.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 5.2 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 4.7 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 4.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 3.7 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 3.7 GO:0031672 A band(GO:0031672)
0.1 3.0 GO:0033270 paranode region of axon(GO:0033270)
0.1 3.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.3 2.8 GO:0071439 clathrin complex(GO:0071439)
0.1 2.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 2.6 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 2.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 2.4 GO:0005770 late endosome(GO:0005770)
0.4 2.3 GO:0061689 tricellular tight junction(GO:0061689)
0.1 2.2 GO:0016592 mediator complex(GO:0016592)
0.7 2.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 2.1 GO:0060077 inhibitory synapse(GO:0060077)
0.0 2.1 GO:0005795 Golgi stack(GO:0005795)
0.0 1.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 201 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 40.2 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.2 8.6 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.7 6.9 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 4.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.3 4.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 4.6 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.2 3.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.7 3.7 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 3.4 GO:0008514 organic anion transmembrane transporter activity(GO:0008514)
0.0 3.3 GO:0017124 SH3 domain binding(GO:0017124)
0.2 2.8 GO:0045504 dynein heavy chain binding(GO:0045504)
0.7 2.6 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 2.6 GO:0050811 GABA receptor binding(GO:0050811)
0.1 2.5 GO:0071889 14-3-3 protein binding(GO:0071889)
0.3 2.4 GO:0031419 cobalamin binding(GO:0031419)
0.3 2.3 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 2.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.4 2.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.7 2.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 2.1 GO:0035612 AP-2 adaptor complex binding(GO:0035612)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 PID_ARF6_PATHWAY Arf6 signaling events
0.1 2.3 PID_MYC_PATHWAY C-MYC pathway
0.0 2.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 2.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.5 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.4 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.2 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.1 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 1.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.0 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.9 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.9 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.8 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 0.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.7 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID_IL2_1PATHWAY IL2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 2.9 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.0 2.9 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
0.1 2.8 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 2.8 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 2.5 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 2.4 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 2.2 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.9 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.9 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 1.7 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.3 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 1.3 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.3 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.0 1.1 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.0 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.0 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 0.9 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 0.9 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 0.8 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1